An Automated RNA 3D Structure Determination System

描述（由申请人提供）：分子生物学的中心教条经历了重大的修订，其中rna已经成为细胞活性的重要调节因子。令人惊讶的是，据DNA元件百科全书（ENCODE）协会最近报道，多达80%的人类DNA被转录成RNA。新的RNA种类正在被发现，其中包括许多非蛋白编码（ncRNA）。尽管如此，ncrna仍参与调节细胞活动。破译这些rna的结构-功能关系具有直接的重要性，因为ncRNAs现在与多种疾病有关，包括1型肌强直性营养不良症、前列腺癌、脊髓性肌萎缩症和亨廷顿病样2。确定高分辨率RNA 3D结构的传统方法已被证明是非常耗时和昂贵的。Nymirum开发了一种自动化RNA 3D结构测定系统，比目前的方法更快，更便宜，更强大。该系统将商业化，供制药行业和学术研究人员用于了解和治疗人类疾病。

DESCRIPTION (provided by applicant): The central dogma of molecular biology has undergone a significant revision where RNAs have emerged as important regulators of cell activity. Astonishingly, as much as 80% of human DNA is transcribed into RNA as recently reported by the Encyclopedia of DNA Elements (ENCODE) consortium. New classes of RNA are being identified including many which are non-protein coding (ncRNA). Nonetheless ncRNAs are involved in regulating cellular activity. Deciphering the structure-function relationship of these RNAs is of immediate importance as ncRNAs have now been implicated in a variety of diseases including myotonic dystrophy type 1, prostate cancer, spinal muscular atrophy, and Huntington's disease-like 2. Traditional approaches to determine high-resolution RNA 3D structures have proven to be prohibitively time consuming and expensive. Nymirum has developed an Automated RNA 3D Structure Determination System that is faster, cheaper, and more robust than current approaches. This System will be commercialized for use by the drug industry and academic researchers in their quest to understand and treat human disease.