An Automated RNA 3D Structure Determination System

描述(由申请人提供)：分子生物学的中心教条已经经历了重大的修改，其中RNA已经成为细胞活动的重要调节因素。令人惊讶的是，正如DNA元素百科全书(ENCODE)联盟最近报道的那样，多达80%的人类DNA被转录成RNA。新的RNA类别正在被发现，其中包括许多非蛋白质编码(NcRNA)。尽管如此，ncRNAs参与调节细胞活动。破译这些RNA的结构-功能关系非常重要，因为ncRNAs现在已经与多种疾病有关，包括强直性肌营养不良1型、前列腺癌、脊髓性肌萎缩症和亨廷顿病样2。传统的方法被证明是非常耗时和昂贵的高分辨率RNA 3D结构。Nymirum开发了一种自动RNA 3D结构确定系统，该系统比目前的方法更快、更便宜、更可靠。该系统将被商业化，供制药行业和学术研究人员使用，以了解和治疗人类疾病。

DESCRIPTION (provided by applicant): The central dogma of molecular biology has undergone a significant revision where RNAs have emerged as important regulators of cell activity. Astonishingly, as much as 80% of human DNA is transcribed into RNA as recently reported by the Encyclopedia of DNA Elements (ENCODE) consortium. New classes of RNA are being identified including many which are non-protein coding (ncRNA). Nonetheless ncRNAs are involved in regulating cellular activity. Deciphering the structure-function relationship of these RNAs is of immediate importance as ncRNAs have now been implicated in a variety of diseases including myotonic dystrophy type 1, prostate cancer, spinal muscular atrophy, and Huntington's disease-like 2. Traditional approaches to determine high-resolution RNA 3D structures have proven to be prohibitively time consuming and expensive. Nymirum has developed an Automated RNA 3D Structure Determination System that is faster, cheaper, and more robust than current approaches. This System will be commercialized for use by the drug industry and academic researchers in their quest to understand and treat human disease.