HMORN UCSF Center for Diabetes Translational Research

在美国，糖尿病是一个重要的健康和成本负担。T2DM预防和护理的证据基础是所有慢性疾病中最完善的证据基础之一；然而，糖尿病护理的总体质量仍然不是最理想的，迄今为止，对预防糖尿病项目的关注相对较少。迫切需要能够有效地将高质量、以证据为基础的糖尿病预防和治疗转化为广泛实践的规划。为了满足这一需求，Kaiser Permanente北加州研究部、HealthPartners研究基金会、Harvard Pilgrim和加州大学旧金山分校的糖尿病研究人员提议创建一个糖尿病转化研究中心（CDTR），该中心将积极促进和支持隶属于HMO研究网络（HMORN）和加利福尼亚州的医疗保健服务系统中糖尿病的转化研究。拟议的HMORN-UCSF CDTR将通过建立一个多学科网络来实现其目标，该网络由在糖尿病转化研究方面拥有强大的联邦和基金会资助历史的成熟研究人员组成。该CDTR将围绕卫生保健差异、糖尿病和肥胖预防以及利用卫生信息技术改善糖尿病护理等领域的三个转化研究核心进行构建。拟议的CDTR研究人员在成人和儿童以及妊娠期糖尿病（GDM）孕妇的T2DM护理和预防的转化研究方面具有丰富的经验。这些调查人员与护理提供系统有着密切的关系，从大型综合提供系统到安全网提供者网络，这些系统可以作为将有效干预措施转化为实际临床环境的重要合作伙伴。

Diabetes mellitus is a significant health and cost burden in the United States. The evidence base for the prevention and care of T2DM is one of the most well-established of any chronic illness; however, the overall quality of care for diabetes remains sub-optimal, and to date relatively little attention has been paid to programs for preventing diabetes. Programs which can effectively translate high-quality, evidence-based diabetes prevention and treatment into widespread practice are desperately needed. In response to this need, diabetes researchers at the Kaiser Permanente Northern California Division of Research, HealthPartners Research Foundation, Harvard Pilgrim, and the University of California San Francisco, propose to create a Center for Diabetes Translational Research (CDTR) that will actively foster and support translational research in diabetes within health care delivery systems affiliated with the HMO Research Network (HMORN) and the State of California. The proposed HMORN-UCSF CDTR will achieve its aims by developing a multi-disciplinary network of well-established investigators with a strong history of receiving both federal and foundation funding in diabetes translational research. This CDTR will be structured around three Translational Research Cores in the areas of health care disparities, diabetes and obesity prevention, and the use of health information technology to improve diabetes care. The proposed CDTR investigators have significant experience in translational research in T2DM care and prevention in both adults and children, as well as in pregnant women with gestational diabetes (GDM). These investigators have strong relationships with care delivery systems, ranging from large integrated delivery systems to networks of safety net providers, that can serve as important partners for translating effective interventions into real-world clinical settings.