HMORN UCSF Center for Diabetes Translational Research

糖尿病在美国是一个重大的健康和成本负担。2型糖尿病的预防和护理的证据基础是任何慢性疾病中最完善的证据基础之一;然而，糖尿病的整体护理质量仍然不佳，迄今为止，对预防糖尿病的计划关注相对较少。迫切需要能够有效地将高质量的循证糖尿病预防和治疗转化为广泛实践的项目。为了满足这一需求，凯泽永久北方加州研究部、HealthPartners研究基金会、哈佛朝圣者和加州大学弗朗西斯科分校的糖尿病研究人员，建议建立一个糖尿病转化研究中心（CDTR），积极促进和支持HMO研究网络（HMORN）附属的医疗保健提供系统内的糖尿病转化研究和加州州政府。拟议的HMORN-UCSF CDTR将通过发展一个由在糖尿病转化研究中有着接受联邦和基金会资助的悠久历史的成熟研究者组成的多学科网络来实现其目标。该CDTR将围绕医疗保健差异、糖尿病和肥胖预防以及使用健康信息技术改善糖尿病护理等领域的三个转化研究核心进行构建。拟议的CDTR研究者在成人和儿童以及妊娠期糖尿病（GDM）孕妇的T2 DM护理和预防的转化研究方面具有丰富的经验。这些研究人员与医疗服务系统有着密切的关系，从大型综合服务系统到安全网提供者网络，这些系统可以作为将有效干预措施转化为现实世界临床环境的重要合作伙伴。

Diabetes mellitus is a significant health and cost burden in the United States. The evidence base for the prevention and care of T2DM is one of the most well-established of any chronic illness; however, the overall quality of care for diabetes remains sub-optimal, and to date relatively little attention has been paid to programs for preventing diabetes. Programs which can effectively translate high-quality, evidence-based diabetes prevention and treatment into widespread practice are desperately needed. In response to this need, diabetes researchers at the Kaiser Permanente Northern California Division of Research, HealthPartners Research Foundation, Harvard Pilgrim, and the University of California San Francisco, propose to create a Center for Diabetes Translational Research (CDTR) that will actively foster and support translational research in diabetes within health care delivery systems affiliated with the HMO Research Network (HMORN) and the State of California. The proposed HMORN-UCSF CDTR will achieve its aims by developing a multi-disciplinary network of well-established investigators with a strong history of receiving both federal and foundation funding in diabetes translational research. This CDTR will be structured around three Translational Research Cores in the areas of health care disparities, diabetes and obesity prevention, and the use of health information technology to improve diabetes care. The proposed CDTR investigators have significant experience in translational research in T2DM care and prevention in both adults and children, as well as in pregnant women with gestational diabetes (GDM). These investigators have strong relationships with care delivery systems, ranging from large integrated delivery systems to networks of safety net providers, that can serve as important partners for translating effective interventions into real-world clinical settings.