Cardiac MR and CT Research

心脏 MR 和 CT 研究

• 批准号: 8794907
• 负责人: UDO HOFFMANN
• 金额: $ 36.23万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8794907
• 关键词: Cardiac; Research

 DESCRIPTION (provided by applicant): We seek continued support for our NIH Training Grant T32 HL076136-10 entitled "Cardiac MR CT Research" based in the Massachusetts General Hospital (MGH) Cardiac MR PET CT program, a joint Radiology/Cardiology program. This renewal application is based on the highly successful track record of this program over the first 10 years, documented by 1) the impact trainees of this program had on the Nation's biomedical, behavioral and clinical research agenda - 69% of former trainees are faculty at academic institutions, 75% serve in regional, national or international leadership positions with a teaching, research, or clinical focus, and 63% have acquired independent funding to continue their research; and 2) training a diverse (11/27 (42%) of all program trainees were underrepresented minority) and highly trained workforce (20 MD; 4 MD PhD; 3 PhD). This renewal application provides an in depth training plan with didactic formal and project based individual training elements across career tracks of Engineering /Physics, Basic and Translational Research, Early Clinical Imaging Research and Trials, and Clinical Trials/Epidemiology/Outcomes in cardiac imaging. The program is supported by 30 well funded faculty members ($64,194,470 of funding for year 1 (2014) of the program; 52 awarded R01 grants and 26 PPG/U01 programs) and 21/30 have already secured independent funding until year 3 (2016) of this application) with experience and a long track record of commitment to mentoring representing ten programs and departments. This faculty combines outstanding expertise in seven focus areas (Computed Tomography, Magnetic Resonance Imaging, other noninvasive Imaging such as PET and Echocardiography, Invasive Imaging (IVUS, OCT), Biomarkers/Genetics/Metabolomics, Cost Effectiveness, and Statistics). Importantly, several large ongoing and funded future trials (PROMISE, ROMICAT II, REPRIEVE) provide outstanding training and research opportunities for MD investigators, while significant basic and translational science work is performed in MR and biomarker areas. The program's administrative structure includes a Program Management Committee, Mentor groups and an External Advisory Board to guarantee an efficient mentoring and supervision of trainees. On 04/01/2012, Udo Hoffmann, MD MPH, a senior clinical trialist with focus on CT, became the PI of the Training Program. He has close research collaborations with the majority of the faculty listed in this application. Dr. Hoffmann, will lead the program together with the Associate Director Tomas G. Neilan, MD, a junior faculty with a complimentary basic/translational MR science focus. Both will closely work with a Program Management Committee and an External Advisory Board. A K24 award supports Dr. Hoffmann's effort and he has additional departmental support for Dr. Neilan and for the administration of the grant. Detailed training plans and clear responsibilities ensure program cohesiveness and foster multidisciplinary research collaboration. Funds are now requested to renew Program for a third 5 year funding cycle.

 描述（由申请人提供）：我们寻求继续支持我们的NIH培训补助金T32 HL 076136 -10，题为“心脏MR CT研究”，基于马萨诸塞州总医院（MGH）心脏MR PET CT计划，一个联合放射学/心脏病学计划。这一更新申请是基于该计划在前10年非常成功的记录，记录如下：1）该计划的学员对国家生物医学，行为和临床研究议程的影响- 69%的前学员是学术机构的教师，75%的人担任区域，国家或国际领导职务， 63%的人获得了独立的资金来继续他们的研究; 2）培训多样化（所有计划学员中有11/27（42%）是代表性不足的少数民族）和训练有素的劳动力（20 MD; 4 MD博士; 3博士）。此更新应用程序提供了一个深入的培训计划，其中包含教学正式和基于项目的个人培训元素，涵盖工程/物理学，基础和转化研究，早期临床成像研究和试验以及心脏成像的临床试验/流行病学/结果。该计划得到30名资金充足的教职员工的支持（该计划第一年（2014年）的资金为64，194，470美元; 52个授予R 01赠款和26个PPG/U 01计划）和21/30已经获得独立资助，直到本申请的第3年（2016年））拥有经验和长期的指导记录，代表了十个项目和部门。该学院结合了七个重点领域的杰出专业知识（计算机断层扫描，磁共振成像，其他非侵入性成像，如PET和超声心动图，侵入性成像（IVUS，OCT），生物标志物/遗传学/代谢组学，成本效益和统计学）。重要的是，几项正在进行和资助的大型未来试验（PROMISE，ROMICAT II，REPRIEVE）为MD研究人员提供了出色的培训和研究机会，同时在MR和生物标志物领域进行了重要的基础和转化科学工作。该计划的行政结构包括一个计划管理委员会，导师小组和一个外部咨询委员会，以保证有效的指导和监督学员。2012年1月4日，Udo Hoffmann，MD MPH，一位专注于CT的高级临床试验专家，成为培训项目的PI。他与本申请中列出的大多数教师有密切的研究合作。霍夫曼博士将与副主任托马斯G。尼兰，医学博士，一个初级教师与免费的基础/翻译MR科学的重点。双方将与项目管理委员会和外部咨询委员会密切合作。K24奖支持霍夫曼博士的努力，他有额外的部门支持尼兰博士和赠款的管理。详细的培训计划和明确的责任确保计划的凝聚力，促进多学科的研究合作。现在需要资金来更新第三个5年供资周期的计划。