qHTS to Identify Inhibitors of the Glycine Cleavage System (GCS)

项目亮点：小目标文库已被筛选，以确定潜在的再利用线索，先进的分析正在进行中，以充分表征有效的活性。

Project highlights: small targeted libraries have been screened to identify potential repurposing leads, and advanced assays are in progress to fully characterize potent actives. During this period, the NCGC has fostered and maintained over 180 active collaborations with both NIH and extramural investigators, facilitating drug discovery efforts across the entire spectrum of human disease. These efforts have led to over 100 high-throughput screens and nearly 60 medicinal chemistry campaigns, providing our collaborators and the general research community a wealth of publications and promising small molecule leads. In addition, the NCGC has undertaken a number of informatic challenges to make better use of existing drug and disease target information and provide the general public with easily accessible resources, further catalyzing the development of new therapies for human disease.