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Cytotoxicity profiling of Genesis library in A673 and Jurkat cells

Cytotoxicity profiling of Genesis library in A673 and Jurkat cells
A673 和 Jurkat 细胞中 Genesis 文库的细胞毒性分析
批准号：
10916066
负责人：
Min Shen
金额：
$12.58万
依托单位：
NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10916066
关键词：
Biological AssayBortezomibCell LineCollaborationsCollectionEwings sarcomaFDA approvedFollow-Up StudiesJurkat CellsLibrariesMalignant NeoplasmsNational Center for Advancing Translational SciencesPharmaceutical PreparationsSourceTechnologyTestingUniversitiesWorkanti-cancercellular targetingcytotoxiccytotoxicitydrug discoveryhigh throughput screeninglactacystinmulticatalytic endopeptidase complexnew therapeutic targetscreeningsmall moleculesmall molecule libraries

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中文摘要
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英文摘要
This project seeks to use qHTS to identify cytotoxic small molecules from within the NCATS screening collection. Follow-up studies will use a variety of secondary assays to characterize hits and identify a subset for subsequent directed target identification efforts. If successful, this effort could identify new druggable targets and mechanisms for drug discovery in cancer. During this period, the NCATS team has completed the high-throughput screen against small molecule libraries in both A673 (Ewing sarcoma) and Jurkat (T-ALL) cell lines. Active compounds have been identified, and will be tested in a battery of cytotoxicity assays.
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会议论文
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国内基金
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bortezomib抑制寨卡病毒复制的分子机制研究
蛋白酶体抑制剂硼替佐米(Bortezomib)对血管渗漏的改善及机制研究
  • 批准号：
    81772041
  • 项目类别：
    面上项目
  • 资助金额：
    55.0万元
  • 批准年份：
    2017
  • 负责人：
    汤耀卿
  • 依托单位：
    上海交通大学
蛋白酶体抑制剂Bortezomib对肺动脉平滑肌细胞钙离子通路的作用研究
  • 批准号：
    81460011
  • 项目类别：
    地区科学基金项目
  • 资助金额：
    40.0万元
  • 批准年份：
    2014
  • 负责人：
    徐磊
  • 依托单位：
    内蒙古医科大学