Specimen Resource Core

标本资源核心

• 批准号: 8915623
• 负责人: MARCUS W BOSENBERG
• 金额: $ 15.96万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8915623
• 关键词: Address; Age; Antibodies; Archives; Basic Science; Bioinformatics; Biostatistics Core; Cancer-Predisposing Gene; Cell Extracts; Clinical; Clinical Data; Clinical Trials; Collection; Complementary DNA; Comprehensive Cancer Center; Core Facility; DNA; Data; Data Analyses; Databases; Ensure; Epidemiology; Family; Formalin; Freezing; Gender; Gene Expression; Genetic; Genetic Services; Guidelines; Immunology; Individual; Institution; Lesion; Link; Lymphocyte; Malignant - descriptor; Molecular; Mutation; Normal Cell; Oligonucleotides; Paraffin Embedding; Pathology; Patients; Peripheral Blood Lymphocyte; Plasmids; Quality Control; RNA; Reagent; Recording of previous events; Research; Research Personnel; Resources; Sampling; Scientist; Serum; Serum Markers; Services; Skin; Skin Cancer; Specimen; System; Technology; Testing; The Cancer Genome Atlas; Time; Tissues; Training; Tumor-Infiltrating Lymphocytes; cancer cell; chromatin modification; clinical practice; cost effective; data management; design; follow-up; meetings; melanoma; member; neoplastic cell; operation; patient population; preclinical study; quality assurance; skin lesion; translational study; tumor

The Specimen Resource Core is the cornerstone of all Yale SPORE in Skin Cancer (YSPORE) activities. It addresses the broad melanoma patient specimen needs of all the projects that are not met by current shared facilities at Yale. The core goes beyond fulfilling the required duties of a Specimen Resource Core delineated by the SPORE guidelines. In addition to collecting, storing and distributing a wide range of specimens and reagents, the core performs quality assurance testing and a wide range of molecular analyses of specimens. More specifically, the core: a) collects a large repertoire of specimens for translational and preclinical studies in melanoma, including melanocytic lesions, melanoma tumors and cells, normal skin, serum, and circulating lymphocytes; b) ensures high quality control and proper long-term storage, annotation, and timely distribution of specimens to YSPORE investigators; c) establishes and maintains a central database of essential pathological, clinical, epidemiological, follow-up information and basic research data generated by the YSPORE projects that is integrated with the Bioinformatics/Biostatistics Core; d) provides special, services such as the analysis of specimens from clinical trials, mutations, chromatin modification, and collection of TlLs (tumor infiltrating lymphocytes; e) maintains and distributes validated reagents (antibodies, oligonucleotides for PCR, DNA, RNA, plasmids, cell extracts) needed for molecular analyses of tumors by different YSPORE investigators; f) establishes links with shared facilities at Yale and similar resources in other institutions, including other SPOREs and sends out samples to collaborating investigators outside of Yale; and g) provides specimens for larger NCI objectives, including melanoma specimens, peripheral blood lymphocytes, and annotated clinical data for The Cancer Genome Atlas (TCGA). The core Interacts extensively with investigators in each project, the Bioinformatics, Clinical Trial Office, Immunology, Critical Technologies for Tissue Services, and Genetics shared facilities of the Yale Comprehensive Cancer Center. The services of the Specimen Resource Core enhance the efficient operation of the translational studies by YSPORE investigators in a cost-effective manner, and expedite the application of discoveries at the bench to clinical practice, and clinical results to basic research.

标本资源核心是所有耶鲁大学皮肤癌孢子（YSPORE）活动的基石。它解决了耶鲁大学目前共享设施无法满足的所有项目对黑色素瘤患者标本的广泛需求。核心超越了《孢子》指南所描述的样本资源核心的职责。除了收集、储存和分发广泛的标本和试剂外，核心还执行质量保证测试和广泛的标本分子分析。更具体地说，核心是：a)为黑色素瘤的转化和临床前研究收集大量标本，包括黑色素细胞病变、黑色素瘤肿瘤和细胞、正常皮肤、血清和循环淋巴细胞；b)确保高质量控制和适当的长期储存、注释，并及时将标本分发给YSPORE调查员；c)建立和维持一个中央数据库，其中包括由YSPORE项目产生的基本病理、临床、流行病学、后续信息和基础研究数据，该数据库与生物信息学/生物统计学核心相结合；d)提供特殊服务，如分析临床试验标本、突变、染色质修饰和收集tll（肿瘤浸润淋巴细胞）；e)维护和分发不同YSPORE研究人员对肿瘤进行分子分析所需的有效试剂（抗体、PCR寡核苷酸、DNA、RNA、质粒、细胞提取物）；f)与耶鲁大学的共享设施和其他机构（包括其他孢子）的类似资源建立联系，并将样本发送给耶鲁大学以外的合作调查人员；g)为更大的NCI目标提供标本，包括黑色素瘤标本、外周血淋巴细胞和癌症基因组图谱（TCGA）的注释临床数据。核心与每个项目的研究人员广泛互动，生物信息学、临床试验办公室、免疫学、组织服务关键技术和遗传学共享耶鲁综合癌症中心的设施。标本资源中心的服务以具有成本效益的方式提高了YSPORE研究人员转化研究的效率，并加快了实验室发现应用于临床实践和临床结果应用于基础研究的速度。