Drug Dependence Clinical Research Program

 描述(由申请人提供)：此核心支持中心拨款申请(P30)申请继续支持分析和合成化学实验室和行政核心基础设施。目前得到资助的组成项目继续开展人体实验室和治疗诊所研究滥用药物的临床药理学、药物疗法和其他治疗策略以治疗药物滥用和成瘾的研究方案。参与项目和研究人员代表的学科包括精神病学、临床心理学、普通内科和临床药理学、心脏病学、肺部内科、儿科和化学。目前，得到支持的项目主要涉及与烟草成瘾有关的问题，但我们也准备支持对其他滥用药物的研究。我们的目标是：(1)为加州大学旧金山分校和其他机构的药物滥用研究人员的参与项目提供最先进的、设备和人员齐全的分析和合成化学实验室资源。(2)就最佳研究设计和数据分析策略提供咨询，特别是关于参与项目的药代动力学分析。总的目标是提供复杂的分析实验室资源，以满足个别构成科学项目的需要，并随着这些项目的变化和发展而变化。这个设施是一个具有成本效益的共享实验室资源，它增强了研究的可能性，以促进我们对人类精神活性药物的使用、滥用和成瘾、其健康后果及其治疗的了解。

 DESCRIPTION (provided by applicant): This Core Support Center Grant (P30) application requests continued support for an analytical and synthetic chemistry laboratory and administrative core infrastructure. The currently funded constituent projects continue research programs with human laboratory and treatment clinic studies of the clinical pharmacology of abused drugs, pharmacotherapies and other treatment strategies to treat drug abuse and addictions. Disciplines represented by the participating projects and investigators include psychiatry, clinical psychology, general internal medicine and clinical pharmacology, cardiology, pulmonary medicine, pediatrics, and chemistry. Currently, the supported projects involve primarily the problems associated with tobacco addiction, but we are prepared to support studies of other abused drugs as well. Our aims are: (1) To provide a state-of-the-art, well equipped and staffed, analytical and synthetic chemistry laboratory resource for the participating projects of drug abuse researchers at UCSF and at other institutions. (2) To provide consultation regarding optimal study design and data analysis strategies, particularly regarding pharmacokinetic analysis for participating projects. The overall objective is to provide sophisticated analytical laboratory resources responsive to the needs of individual constituent scientific projects as these projects change and evolve. This facility is a cost-effective shared laboratory resource that enhances research possibilities to further our understanding of human psychoactive drug use, abuse and addiction, its health consequences and its treatment.