The University of Iowa Clinical and Translational Science Award

爱荷华大学临床和转化科学奖

• 批准号: 9127390
• 负责人: Patricia Winokur
• 金额: $ 356.07万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-14 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9127390
• 关键词: Academic Medical Centers; Academic support; Academy; Acceleration; Adoption; Affect; American; Area; Arts; Award; Behavioral; Caring; Child; Child Abuse; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communication; Communities; Community Practice; Community of Practice; Computerized Medical Record; Data; Development; Dimensions; Discipline; Disease; Distance Learning; Elderly; Enabling Factors; Epidemiologic Studies; Estrogens; Faculty; Family Physicians; Fostering; Funding; Genetic; Goals; Grant; Health; Health Alliance; Health system; Healthcare; Heart; Hereditary Disease; Hospitals; Human Subject Research; Individual; Institute of Medicine (U.S.); Institutes; Institution; Iowa; Knowledge; Lead; Learning; Link; Locales; Longevity; Longitudinal Studies; Measurable; Medical; Mental disorders; Methods; Mission; Modeling; Multicenter Neonatal Research Network; Patients; Persons; Pharmacists; Phase; Physicians; Population; Positioning Attribute; Postmenopause; Process; Recruitment Activity; Research; Research Design; Research Methodology; Research Personnel; Resources; Risk Factors; Rural; Rural Community; Rural Health; Rural Population; School Nursing; Science; Shapes; Site; Stable Populations; Statistical Methods; System; Technology; Testing; Textiles; Touch sensation; Training; Translating; Translational Research; Translations; Trust; United States National Academy of Sciences; United States National Institutes of Health; Universities; Vision; Woman; Women' s Health; Work; Workforce Development; base; cardiovascular risk factor; catalyst; clinical practice; community organizations; critical access hospital; evidence base; functional decline; health care delivery; improved; informatics infrastructure; innovation; interest; logarithm; medical specialties; meetings; member; multidisciplinary; next generation; novel; novel strategies; novel therapeutics; population health; programs; public health relevance; social; workforce needs; working group

 DESCRIPTION (provided by applicant): The Institute for Clinical and Translational Science (ICTS) at the University of Iowa (UI) was established by the Board of Regents to realize three objectives - first, to lead the development of translational science at the UI; second, to advance translational science as a distinct academic discipline; and third, to disseminate capacities in translational science across the State of Iowa. This mandate enabled us to tackle large problems affecting translational science that required institutional solutions, such as transforming regulatory processes for human subjects research, developing an informatics infrastructure for integrating electronic medical record and other health care data, establishing bi-directional relationships with community organizations, and revitalizing the pipeline of well-trained clinical and translational researchers. The task for this new application is extend our impact and to build a model learning health system (LHS) to integrate research and practice across the lifespan and across the T0 - T4 translational spectrum with the intent of accelerating the translation of discovery to improved population health. Becoming an exemplary next generation CTSA that can produce logarithmic acceleration requires refocusing many current programs and creating new resources to: (1) promote workforce development; (2) systematically engage stakeholders; (3) integrate translational research along several distinct dimensions; and (4) spur innovation. The milestones for this application have a special focus on rural health, community engagement, research- practice integration, clinical research efficiency, innovative statistical methods, and rare genetic diseases. In addition, some of the milestones reflect our interest in working with other CTSA hubs to empirically test different approaches and for developing an evidence base of proven strategies for accelerating translation that can be more broadly disseminated. In this way we can incentivize the development and adoption of new methods and promote innovation in everyday research processes throughout Iowa and beyond our borders. In particular, we will engage investigators and stakeholders across Iowa using approaches that overcome the geographic barriers in a rural state and that build on our established community practice networks of family physicians, clinics, school nurses and pharmacists, with particular examples related to lifespan research and child abuse. To build this LHS we will engage and train undergraduates, pre and postdoctoral trainees, established investigators research staff and clinicians at the UI and in the newly formed UI Health Alliance (an integrated network of 58 hospitals, 175 clinics, critical access hospitals in rural communities regional medical centers, and the UI) which touches 60% of the population in Iowa to drive clinical and translational discovery and to change healthcare practice in a variety of clinical settings.



项目成果

Factors Associated With Humeral Avulsion of Glenohumeral Ligament Lesions in Patients With Anterior Shoulder Instability: An Analysis of the MOON Shoulder Instability Cohort.

• DOI: 10.1177/23259671231206757
• 发表时间: 2023-10
• 期刊: ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
• 影响因子: 2.6
• 作者: Freshman, Ryan D.;Zhang, Alan L.;Benjamin Ma, C.;Feeley, Brian T.;Ortiz, Shannon;Patel, Jhillika;Dunn, Warren;Wolf, Brian R.;Hettrich, Carolyn;Lansdown, Drew
• 通讯作者: Lansdown, Drew

Sodium nitrate supplementation improves blood pressure reactivity in patients with peripheral artery disease.

补充硝酸钠可改善外周动脉疾病患者的血压反应性。

• DOI: 10.1016/j.numecd.2021.12.002
• 发表时间: 2022-03
• 期刊: Nutrition, metabolism, and cardiovascular diseases : NMCD
• 作者: Hughes WE;Treichler DP;Ueda K;Bock JM;Casey DP
• 通讯作者: Casey DP

Career Development Support in Pediatric Critical Care Medicine: A National Survey of Fellows and Junior Faculty.

• DOI: 10.1097/pcc.0000000000001097
• 发表时间: 2017-04
• 期刊: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
• 作者: Cifra CL;Balikai SS;Murtha TD;Hsu B;Riley CL
• 通讯作者: Riley CL

Preliminary findings from a concise emergency department model to predict anaphylaxis and develop a clinical decision support tool.

简明急诊科模型的初步结果可预测过敏反应并开发临床决策支持工具。

• DOI: 10.1016/j.jaip.2019.04.002
• 发表时间: 2019
• 期刊: The journal of allergy and clinical immunology. In practice
• 作者: Lee,Sangil;Hardy,Cassandra;Swanson,MorganBobb;Harland,Karisa;Ahmed,Azeemuddin;Ballas,Zuhair
• 通讯作者: Ballas,Zuhair

Predicting changes in hemoglobin S after simple transfusion using complete blood counts.

• DOI: 10.1111/trf.14371
• 发表时间: 2018-01
• 期刊: Transfusion
• 影响因子: 2.9
• 作者: Mathur G;Ten Eyck P;Knudson CM
• 通讯作者: Knudson CM