The University of Iowa Clinical and Translational Science Award

 简介(由申请人提供)：爱荷华大学临床与翻译科学研究所(ICTS)由董事会建立，目的是实现三个目标--第一，领导爱荷华大学临床与翻译科学的发展；第二，推动翻译科学作为一门独特的学术学科；第三，在爱荷华州传播翻译科学的能力。这项任务使我们能够解决影响翻译科学的重大问题，这些问题需要体制解决方案，例如改变人类受试者研究的监管程序，开发用于整合电子病历和其他医疗保健数据的信息基础设施，与社区组织建立双向关系，以及重振训练有素的临床和翻译研究人员的管道。这一新应用程序的任务是扩大我们的影响，并建立一个模型学习健康系统(LHS)，以整合整个生命周期和T0-T4翻译谱的研究和实践，目的是加快将发现转化为改善人口健康的过程。要成为能够产生对数加速的模范下一代CTSA，需要重新关注当前的许多计划并创造新的资源，以：(1)促进劳动力发展；(2)系统地吸引利益相关者；(3)整合几个不同维度的翻译研究；以及(4)刺激创新。 这一应用的里程碑特别关注农村卫生、社区参与、研究-实践一体化、临床研究效率、创新的统计方法和罕见的遗传疾病。此外，一些里程碑反映了我们有兴趣与CTSA的其他中心合作，对不同的方法进行经验测试，并开发一个证据基础，证明可以更广泛地传播的加速翻译的成熟战略。通过这种方式，我们可以鼓励开发和采用新方法，并促进爱荷华州内外日常研究过程中的创新。特别是，我们将让爱荷华州的调查人员和利益相关者参与进来，使用的方法是克服农村州的地理障碍，并建立在我们由家庭医生、诊所、学校护士和药剂师组成的社区实践网络的基础上，特别是与寿命研究和虐待儿童有关的例子。为了建立这个LHS，我们将在爱荷华州大学和新成立的大学健康联盟(由58家医院、175家诊所、农村社区关键通道医院、区域医疗中心和大学学院组成的综合网络)中招募和培训本科生、博士后学员、知名研究人员和临床医生，以推动临床和翻译发现，并改变各种临床环境中的医疗实践。

 DESCRIPTION (provided by applicant): The Institute for Clinical and Translational Science (ICTS) at the University of Iowa (UI) was established by the Board of Regents to realize three objectives - first, to lead the development of translational science at the UI; second, to advance translational science as a distinct academic discipline; and third, to disseminate capacities in translational science across the State of Iowa. This mandate enabled us to tackle large problems affecting translational science that required institutional solutions, such as transforming regulatory processes for human subjects research, developing an informatics infrastructure for integrating electronic medical record and other health care data, establishing bi-directional relationships with community organizations, and revitalizing the pipeline of well-trained clinical and translational researchers. The task for this new application is extend our impact and to build a model learning health system (LHS) to integrate research and practice across the lifespan and across the T0 - T4 translational spectrum with the intent of accelerating the translation of discovery to improved population health. Becoming an exemplary next generation CTSA that can produce logarithmic acceleration requires refocusing many current programs and creating new resources to: (1) promote workforce development; (2) systematically engage stakeholders; (3) integrate translational research along several distinct dimensions; and (4) spur innovation. The milestones for this application have a special focus on rural health, community engagement, research- practice integration, clinical research efficiency, innovative statistical methods, and rare genetic diseases. In addition, some of the milestones reflect our interest in working with other CTSA hubs to empirically test different approaches and for developing an evidence base of proven strategies for accelerating translation that can be more broadly disseminated. In this way we can incentivize the development and adoption of new methods and promote innovation in everyday research processes throughout Iowa and beyond our borders. In particular, we will engage investigators and stakeholders across Iowa using approaches that overcome the geographic barriers in a rural state and that build on our established community practice networks of family physicians, clinics, school nurses and pharmacists, with particular examples related to lifespan research and child abuse. To build this LHS we will engage and train undergraduates, pre and postdoctoral trainees, established investigators research staff and clinicians at the UI and in the newly formed UI Health Alliance (an integrated network of 58 hospitals, 175 clinics, critical access hospitals in rural communities regional medical centers, and the UI) which touches 60% of the population in Iowa to drive clinical and translational discovery and to change healthcare practice in a variety of clinical settings.