The University of Iowa Clinical and Translational Science Award

爱荷华大学临床和转化科学奖

• 批准号: 9127390
• 负责人: Patricia Winokur
• 金额: $ 356.07万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-14 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9127390
• 关键词: Academic Medical Centers; Academic support; Academy; Acceleration; Adoption; Affect; American; Area; Arts; Award; Behavioral; Caring; Child; Child Abuse; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Communication; Communities; Community Practice; Community of Practice; Computerized Medical Record; Data; Development; Dimensions; Discipline; Disease; Distance Learning; Elderly; Enabling Factors; Epidemiologic Studies; Estrogens; Faculty; Family Physicians; Fostering; Funding; Genetic; Goals; Grant; Health; Health Alliance; Health system; Healthcare; Heart; Hereditary Disease; Hospitals; Human Subject Research; Individual; Institute of Medicine (U.S.); Institutes; Institution; Iowa; Knowledge; Lead; Learning; Link; Locales; Longevity; Longitudinal Studies; Measurable; Medical; Mental disorders; Methods; Mission; Modeling; Multicenter Neonatal Research Network; Patients; Persons; Pharmacists; Phase; Physicians; Population; Positioning Attribute; Postmenopause; Process; Recruitment Activity; Research; Research Design; Research Methodology; Research Personnel; Resources; Risk Factors; Rural; Rural Community; Rural Health; Rural Population; School Nursing; Science; Shapes; Site; Stable Populations; Statistical Methods; System; Technology; Testing; Textiles; Touch sensation; Training; Translating; Translational Research; Translations; Trust; United States National Academy of Sciences; United States National Institutes of Health; Universities; Vision; Woman; Women' s Health; Work; Workforce Development; base; cardiovascular risk factor; catalyst; clinical practice; community organizations; critical access hospital; evidence base; functional decline; health care delivery; improved; informatics infrastructure; innovation; interest; logarithm; medical specialties; meetings; member; multidisciplinary; next generation; novel; novel strategies; novel therapeutics; population health; programs; public health relevance; social; workforce needs; working group

 DESCRIPTION (provided by applicant): The Institute for Clinical and Translational Science (ICTS) at the University of Iowa (UI) was established by the Board of Regents to realize three objectives - first, to lead the development of translational science at the UI; second, to advance translational science as a distinct academic discipline; and third, to disseminate capacities in translational science across the State of Iowa. This mandate enabled us to tackle large problems affecting translational science that required institutional solutions, such as transforming regulatory processes for human subjects research, developing an informatics infrastructure for integrating electronic medical record and other health care data, establishing bi-directional relationships with community organizations, and revitalizing the pipeline of well-trained clinical and translational researchers. The task for this new application is extend our impact and to build a model learning health system (LHS) to integrate research and practice across the lifespan and across the T0 - T4 translational spectrum with the intent of accelerating the translation of discovery to improved population health. Becoming an exemplary next generation CTSA that can produce logarithmic acceleration requires refocusing many current programs and creating new resources to: (1) promote workforce development; (2) systematically engage stakeholders; (3) integrate translational research along several distinct dimensions; and (4) spur innovation. The milestones for this application have a special focus on rural health, community engagement, research- practice integration, clinical research efficiency, innovative statistical methods, and rare genetic diseases. In addition, some of the milestones reflect our interest in working with other CTSA hubs to empirically test different approaches and for developing an evidence base of proven strategies for accelerating translation that can be more broadly disseminated. In this way we can incentivize the development and adoption of new methods and promote innovation in everyday research processes throughout Iowa and beyond our borders. In particular, we will engage investigators and stakeholders across Iowa using approaches that overcome the geographic barriers in a rural state and that build on our established community practice networks of family physicians, clinics, school nurses and pharmacists, with particular examples related to lifespan research and child abuse. To build this LHS we will engage and train undergraduates, pre and postdoctoral trainees, established investigators research staff and clinicians at the UI and in the newly formed UI Health Alliance (an integrated network of 58 hospitals, 175 clinics, critical access hospitals in rural communities regional medical centers, and the UI) which touches 60% of the population in Iowa to drive clinical and translational discovery and to change healthcare practice in a variety of clinical settings.

 描述（由申请人提供）：爱荷华大学（UI）临床与转化科学研究所（ICTS）由董事会成立，旨在实现三个目标：第一，引领爱荷华大学转化科学的发展；其次，推动转化科学成为一门独特的学科；第三，在爱荷华州传播转化科学的能力。这项任务使我们能够解决影响转化科学的重大问题，这些问题需要制度解决方案，例如转变人类受试者研究的监管流程，开发用于整合电子病历和其他医疗保健数据的信息学基础设施，与社区组织建立双向关系，以及振兴训练有素的临床和转化研究人员的渠道。这个新应用程序的任务是扩大我们的影响并建立一个模型学习健康系统 (LHS)，以整合整个生命周期和 T0 - T4 转化谱的研究和实践，旨在加速发现的转化，以改善人口健康。要成为能够产生对数加速度的下一代 CTSA 典范，需要重新调整许多当前计划并创造新资源，以：(1) 促进劳动力发展； (2) 系统地吸引利益相关者参与； （3）沿着几个不同的维度整合转化研究； (4) 刺激创新。 该应用程序的里程碑特别关注农村健康、社区参与、研究实践整合、临床研究效率、创新统计方法和罕见遗传疾病。此外，一些里程碑反映了我们有兴趣与其他 CTSA 中心合作，对不同的方法进行实证测试，并开发经过验证的策略的证据基础，以加速可更广泛传播的加速翻译。通过这种方式，我们可以激励新方法的开发和采用，并促进爱荷华州内外日常研究过程的创新。特别是，我们将让爱荷华州各地的调查人员和利益相关者参与进来，采用克服农村州地理障碍的方法，并建立在我们已建立的家庭医生、诊所、学校护士和药剂师社区实践网络的基础上，特别是与寿命研究和虐待儿童有关的例子。为了建立这个 LHS，我们将在 UI 和新成立的 UI Health Alliance（由 58 家医院、175 家诊所、农村社区的关键医院、区域医疗中心和 UI 组成的综合网络）中招募和培训本科生、博士前和博士后学员、固定调查人员、研究人员和临床医生，该联盟覆盖爱荷华州 60% 的人口，以推动临床和转化发现并改变医疗保健 在各种临床环境中进行实践。

项目成果

Factors Associated With Humeral Avulsion of Glenohumeral Ligament Lesions in Patients With Anterior Shoulder Instability: An Analysis of the MOON Shoulder Instability Cohort.

• DOI: 10.1177/23259671231206757
• 发表时间: 2023-10
• 期刊: ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
• 影响因子: 2.6
• 作者: Freshman, Ryan D.;Zhang, Alan L.;Benjamin Ma, C.;Feeley, Brian T.;Ortiz, Shannon;Patel, Jhillika;Dunn, Warren;Wolf, Brian R.;Hettrich, Carolyn;Lansdown, Drew
• 通讯作者: Lansdown, Drew

Sodium nitrate supplementation improves blood pressure reactivity in patients with peripheral artery disease.

补充硝酸钠可改善外周动脉疾病患者的血压反应性。

• DOI: 10.1016/j.numecd.2021.12.002
• 发表时间: 2022-03
• 期刊: Nutrition, metabolism, and cardiovascular diseases : NMCD
• 作者: Hughes WE;Treichler DP;Ueda K;Bock JM;Casey DP
• 通讯作者: Casey DP

Career Development Support in Pediatric Critical Care Medicine: A National Survey of Fellows and Junior Faculty.

• DOI: 10.1097/pcc.0000000000001097
• 发表时间: 2017-04
• 期刊: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
• 作者: Cifra CL;Balikai SS;Murtha TD;Hsu B;Riley CL
• 通讯作者: Riley CL

Preliminary findings from a concise emergency department model to predict anaphylaxis and develop a clinical decision support tool.

简明急诊科模型的初步结果可预测过敏反应并开发临床决策支持工具。

• DOI: 10.1016/j.jaip.2019.04.002
• 发表时间: 2019
• 期刊: The journal of allergy and clinical immunology. In practice
• 作者: Lee,Sangil;Hardy,Cassandra;Swanson,MorganBobb;Harland,Karisa;Ahmed,Azeemuddin;Ballas,Zuhair
• 通讯作者: Ballas,Zuhair

Normal Saline Solution and Lactated Ringer's Solution Have a Similar Effect on Quality of Recovery: A Randomized Controlled Trial.

生理盐水和乳酸林格氏溶液对恢复质量有类似的影响：随机对照试验。

• DOI: 10.1016/j.annemergmed.2018.07.007
• 发表时间: 2019
• 期刊: Annals of emergency medicine
• 影响因子: 6.2
• 作者: Friederich,Andrew;Martin,Natalie;Swanson,MorganB;Faine,BrettA;Mohr,NicholasM
• 通讯作者: Mohr,NicholasM