OTHER FUNCTIONS TAS::75 0849::TAS AGRICULTURAL HEALTH STUDY PHASE IV--MOD 3:
其他功能 TAS::75 0849::TAS 农业健康研究第四阶段--MOD 3:
基本信息
- 批准号:9201177
- 负责人:
- 金额:$ 18.61万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-23 至 2016-09-22
- 项目状态:已结题
- 来源:
- 关键词:AddressAgeAgricultureAwardB-LymphocytesBiologicalBiological MarkersBloodBusinessesCarcinogenesis MechanismCessation of lifeChronic Lymphocytic LeukemiaCohort StudiesCollectionColorectalComputer SystemsContractorContractsCountyDataData FilesDatabasesEnrollmentEtiologyFundingFutureGeneral PopulationHealthHome environmentIncidenceInstitutesInterviewIowaLicensingLinkLungLymphocytosisMalignant NeoplasmsMolecular EpidemiologyMonoclonal gammopathy of uncertain significanceMultiple MyelomaNational Health and Nutrition Examination SurveyNewsletterNorth CarolinaOccupational ExposureOvarianParticipantPesticidesPhasePrevalencePrevalence StudyProstateProstate, Lung, Colorectal, and Ovarian Cancer Screening TrialProtocols documentationQuestionnairesRecordsRecruitment ActivityResearchResearch PersonnelResourcesRetrievalSamplingSecureSelf-AdministeredSpecific qualifier valueSpecimenSpousesStagingStudy SubjectTechnologyTelephone InterviewsUniversitiesUpdateUrineWorkcohortfarmerfield studyfollow-upindexinginterestleukemialifestyle factorsmeetingsmembermortalityneoplasm registryoperationphase 1 studyphase 2 studyphase 3 studyphase 4 studypopulation basedresearch studytechnology developmentweb site
项目摘要
The Agricultural Health Study (AHS) cohort consists of approximately 52,000 private pesticide applicators (primarily farmers) and 32,000 spouses of private applicators from Iowa and North Carolina, as well as approximately 5,000 commercial pesticide applicators from Iowa. The pesticide applicators were recruited between 1993-1997 (during Phase I of the AHS) when they obtained or renewed their license to apply restricted use pesticides; spouses were recruited largely by questionnaires brought home by the
pesticide applicator (81%). In addition to the extensive information on lifetime use of pesticides, demographic and other lifestyle factors were collected from all participants at enrollment using self-administered questionnaires (during Phase I of the AHS). Two follow-up telephone interviews have been conducted since enrollment. The first follow-up interview was conducted from 1999 to 2003 (during Phase II of AHS), and the second follow-up interview was conducted from 2005-2009 (during Phase III of the AHS). Cancer incidence has been ascertained by annual linkage to the cancer registries in each state and mortality through linkage to the National Death Index since the inception of the study field work in 1993.
The AHS began field work for Phase I of the study with three contracts in 1993. One contract was for a coordinating center (SRA Technology) which was primarily responsible for overall coordination of the study, developing questionnaires, and providing a secure computer system to store the vast amount of questionnaire and other research data coming from the field stations in Iowa and North Carolina. The other two contracts were for a field station in Iowa (University of Iowa) and a second field station in North Carolina (Battelle Memorial Institute). Field Stations were primarily responsible for managing the distribution and retrieval of self-administered questionnaires to eligible study subjects. The coordinating center contract was awarded, via a full and open competition, to SRA Technologies for Phase II of the study and to Westat Inc. for Phase III of the study; Westat assumed the coordinating center contract during Phase II when SRA Technologies went out of business. The field station contracts were awarded again, via a full and open competition, to the University of Iowa in Iowa and Battelle Memorial Institute in North Carolina for Phases II and III of the study.
In the Phase IV contract, the contractor will be responsible for overall coordination and day-to-day management of the study, maintaining and updating a secure data base containing all study research and administrative records, provide liaison with appropriate state and federal offices necessary to conduct this research, appropriately communicate research findings to the cohort through a website and annual newsletter, and to collect specified biospecimens from selected study subjects. In Phase IV of the AHS, one contractor will perform all study related activities as there will be no cohort-wide interview conducted as part of this contract. The coordinating center will continue to be responsible for day-to-day study operations, managing and maintaining study data files, and coordinating National Advisory Panel meetings. In addition, the coordinating center will now assume responsibility for maintaining and securing the personal identifying information for cohort members; conducting annual linkages to the state cancer registries, state and federal mortality files, IRS address data bases; and facilitating add-on studies. New responsibilities under this contract will be the conduct of the Biomarker Study (BEEA: protocol attached in appendix) which will involve the collection of blood and urine samples from a subset of the cohort.
农业健康研究(AHS)队列包括来自爱荷华州和北卡罗来纳州的约52,000名私人农药施用者(主要是农民)和32,000名私人施用者的配偶,以及来自爱荷华州的约5,000名商业农药施用者。农药施用者是在1993-1997年(AHS第一阶段期间)获得或更新其施用限制使用农药的许可证时招募的;配偶主要通过由卫生部带回家的问卷招募。
农药施用者(81%)。除了关于农药终生使用的广泛信息外,还使用自填问卷(在AHS的第一阶段)从所有参与者中收集人口统计学和其他生活方式因素。入组后进行了两次电话随访。第一次随访于1999年至2003年(AHS第二阶段)进行,第二次随访于2005年至2009年(AHS第三阶段)进行。自1993年开始实地研究工作以来,癌症发病率通过每年与各州癌症登记处的联系和死亡率通过与国家死亡指数的联系来确定。
1993年,AHS开始了第一阶段研究的实地工作,签订了三份合同。其中一份合同是一个协调中心(SRA技术公司),主要负责研究的总体协调、制定调查问卷,并提供一个安全的计算机系统,以存储来自爱荷华州和北卡罗来纳州现场工作站的大量调查问卷和其他研究数据。另外两份合同是关于在爱荷华州(爱荷华州大学)的一个外地站和在北卡罗来纳州(巴特尔纪念研究所)的第二个外地站。现场工作站主要负责管理向合格研究受试者分发和收回自填问卷。协调中心合同通过全面公开的竞争授予SRA Technologies(研究II期)和Westat Inc.。研究的第三阶段; Westat在SRA Technologies停业的第二阶段承担了协调中心合同。通过全面和公开的竞争,野外台站合同再次授予爱荷华州的爱荷华州大学和北卡罗来纳州的巴特尔纪念研究所,用于研究的第二和第三阶段。
在IV期合同中,承包商将负责研究的总体协调和日常管理,维护和更新包含所有研究和管理记录的安全数据库,与进行本研究所需的适当州和联邦办公室进行联络,通过网站和年度通讯向队列适当传达研究结果,并从选定的研究受试者中采集指定的生物样本。在AHS的第IV阶段,一名承包商将执行所有研究相关活动,因为作为本合同的一部分,将不进行队列范围的访谈。协调中心将继续负责日常研究操作,管理和维护研究数据文件,并协调国家咨询小组会议。此外,协调中心现在将负责维护和保护队列成员的个人识别信息;每年与州癌症登记处、州和联邦死亡率档案、IRS地址数据库建立联系;并促进附加研究。本合同项下的新职责将是开展生物标志物研究(BEEA:附录中随附的方案),该研究将涉及从队列的一个子集中采集血液和尿液样本。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('MARSHA DUNN', 18)}}的其他基金
PROFESSIONAL SUPPORT FOR CANCER CONTROL AND POPULATION BASED RESEARCH NIH/NCI/DCCPS SURVEILLANCE RESEARCH PROGRAM
癌症控制和基于人群的研究的专业支持 NIH/NCI/DCCPS 监测研究计划
- 批准号:
10839745 - 财政年份:2021
- 资助金额:
$ 18.61万 - 项目类别:
PROFESSIONAL SUPPORT FOR CANCER CONTROL AND POPULATION BASED RESEARCH NIH/NCI/DCCPS SURVEILLANCE RESEARCH PROGRAM
癌症控制和基于人群的研究的专业支持 NIH/NCI/DCCPS 监测研究计划
- 批准号:
10505105 - 财政年份:2021
- 资助金额:
$ 18.61万 - 项目类别:
PROFESSIONAL SUPPORT FOR CANCER CONTROL AND POPULATION BASED RESEARCH NIH/NCI/DCCPS SURVEILLANCE RESEARCH PROGRAM
癌症控制和基于人群的研究的专业支持 NIH/NCI/DCCPS 监测研究计划
- 批准号:
10683916 - 财政年份:2021
- 资助金额:
$ 18.61万 - 项目类别:
Professional Support for Cancer Control and Population Based Research Contract HHSN261201600004B BPA Call Order - POP 9/16/2019-9/15/2020.
癌症控制和基于人群的研究合同的专业支持 HHSN261201600004B BPA 征集订单 - POP 9/16/2019-9/15/2020。
- 批准号:
10038434 - 财政年份:2016
- 资助金额:
$ 18.61万 - 项目类别:
OTHER FUNCTIONS TAS::75 0849::TAS AGRICULTURAL HEALTH STUDY PHASE IV--MOD 3:
其他功能 TAS::75 0849::TAS 农业健康研究第四阶段--MOD 3:
- 批准号:
9004567 - 财政年份:2011
- 资助金额:
$ 18.61万 - 项目类别:
OTHER FUNCTIONS TAS::75 0849::TAS AGRICULTURAL HEALTH STUDY PHASE IV--MOD 3:
其他功能 TAS::75 0849::TAS 农业健康研究第四阶段--MOD 3:
- 批准号:
8844790 - 财政年份:2011
- 资助金额:
$ 18.61万 - 项目类别:
OTHER FUNCTIONS TAS::75 0849::TAS AGRICULTURAL HEALTH STUDY PHASE IV--MOD 3:
其他功能 TAS::75 0849::TAS 农业健康研究第四阶段--MOD 3:
- 批准号:
8563044 - 财政年份:2011
- 资助金额:
$ 18.61万 - 项目类别:
OTHER FUNCTIONS TAS::75 0849::TAS AGRICULTURAL HEALTH STUDY PHASE IV--MOD 3:
其他功能 TAS::75 0849::TAS 农业健康研究第四阶段--MOD 3:
- 批准号:
8685841 - 财政年份:2011
- 资助金额:
$ 18.61万 - 项目类别:
BRP Global Support Contract, 07/01/2007 - 06/30/2008. Ref contract# NCI-70044-NG
BRP 全球支持合同,2007 年 1 月 7 日至 2008 年 6 月 30 日。
- 批准号:
7544133 - 财政年份:2007
- 资助金额:
$ 18.61万 - 项目类别:
THE AGRICULTURAL HEALTH STUDY - COORDINATING CENTER
农业健康研究 - 协调中心
- 批准号:
7789060 - 财政年份:2003
- 资助金额:
$ 18.61万 - 项目类别:
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