OTHER FUNCTIONS TAS::75 0849::TAS AGRICULTURAL HEALTH STUDY PHASE IV--MOD 3:

其他功能 TAS::75 0849::TAS 农业健康研究第四阶段--MOD 3：

• 批准号: 9201177
• 负责人: MARSHA DUNN
• 金额: $ 18.61万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-23 至 2016-09-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9201177
• 关键词: Address; Age; Agriculture; Award; B-Lymphocytes; Biological; Biological Markers; Blood; Businesses; Carcinogenesis Mechanism; Cessation of life; Chronic Lymphocytic Leukemia; Cohort Studies; Collection; Colorectal; Computer Systems; Contractor; Contracts; County; Data; Data Files; Databases; Enrollment; Etiology; Funding; Future; General Population; Health; Home environment; Incidence; Institutes; Interview; Iowa; Licensing; Link; Lung; Lymphocytosis; Malignant Neoplasms; Molecular Epidemiology; Monoclonal gammopathy of uncertain significance; Multiple Myeloma; National Health and Nutrition Examination Survey; Newsletter; North Carolina; Occupational Exposure; Ovarian; Participant; Pesticides; Phase; Prevalence; Prevalence Study; Prostate; Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial; Protocols documentation; Questionnaires; Records; Recruitment Activity; Research; Research Personnel; Resources; Retrieval; Sampling; Secure; Self-Administered; Specific qualifier value; Specimen; Spouses; Staging; Study Subject; Technology; Telephone Interviews; Universities; Update; Urine; Work; cohort; farmer; field study; follow-up; indexing; interest; leukemia; lifestyle factors; meetings; member; mortality; neoplasm registry; operation; phase 1 study; phase 2 study; phase 3 study; phase 4 study; population based; research study; technology development; web site

The Agricultural Health Study (AHS) cohort consists of approximately 52,000 private pesticide applicators (primarily farmers) and 32,000 spouses of private applicators from Iowa and North Carolina, as well as approximately 5,000 commercial pesticide applicators from Iowa. The pesticide applicators were recruited between 1993-1997 (during Phase I of the AHS) when they obtained or renewed their license to apply restricted use pesticides; spouses were recruited largely by questionnaires brought home by the pesticide applicator (81%). In addition to the extensive information on lifetime use of pesticides, demographic and other lifestyle factors were collected from all participants at enrollment using self-administered questionnaires (during Phase I of the AHS). Two follow-up telephone interviews have been conducted since enrollment. The first follow-up interview was conducted from 1999 to 2003 (during Phase II of AHS), and the second follow-up interview was conducted from 2005-2009 (during Phase III of the AHS). Cancer incidence has been ascertained by annual linkage to the cancer registries in each state and mortality through linkage to the National Death Index since the inception of the study field work in 1993. The AHS began field work for Phase I of the study with three contracts in 1993. One contract was for a coordinating center (SRA Technology) which was primarily responsible for overall coordination of the study, developing questionnaires, and providing a secure computer system to store the vast amount of questionnaire and other research data coming from the field stations in Iowa and North Carolina. The other two contracts were for a field station in Iowa (University of Iowa) and a second field station in North Carolina (Battelle Memorial Institute). Field Stations were primarily responsible for managing the distribution and retrieval of self-administered questionnaires to eligible study subjects. The coordinating center contract was awarded, via a full and open competition, to SRA Technologies for Phase II of the study and to Westat Inc. for Phase III of the study; Westat assumed the coordinating center contract during Phase II when SRA Technologies went out of business. The field station contracts were awarded again, via a full and open competition, to the University of Iowa in Iowa and Battelle Memorial Institute in North Carolina for Phases II and III of the study. In the Phase IV contract, the contractor will be responsible for overall coordination and day-to-day management of the study, maintaining and updating a secure data base containing all study research and administrative records, provide liaison with appropriate state and federal offices necessary to conduct this research, appropriately communicate research findings to the cohort through a website and annual newsletter, and to collect specified biospecimens from selected study subjects. In Phase IV of the AHS, one contractor will perform all study related activities as there will be no cohort-wide interview conducted as part of this contract. The coordinating center will continue to be responsible for day-to-day study operations, managing and maintaining study data files, and coordinating National Advisory Panel meetings. In addition, the coordinating center will now assume responsibility for maintaining and securing the personal identifying information for cohort members; conducting annual linkages to the state cancer registries, state and federal mortality files, IRS address data bases; and facilitating add-on studies. New responsibilities under this contract will be the conduct of the Biomarker Study (BEEA: protocol attached in appendix) which will involve the collection of blood and urine samples from a subset of the cohort.

农业健康研究（AHS）队列包括来自爱荷华州和北卡罗来纳州的约52,000名私人农药施用者（主要是农民）和32,000名私人农药施用者的配偶，以及约5,000名来自爱荷华州的商业农药施用者。农药喷洒员是在1993-1997年（美国农业安全计划第一阶段）取得或续期限制使用农药许可证时招募的；配偶的招募主要是通过调查问卷进行的