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Borrelia miyamotoi: mechanisms of tick colonization and transmission

Borrelia miyamotoi: mechanisms of tick colonization and transmission
宫本伯氏疏螺旋体：蜱的定植和传播机制
批准号：
9196769
负责人：
Brian Stevenson
金额：
$23.95万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
项目状态：
已结题
起止时间：
2016-07-01 至 2018-06-30
来源：
https://reporter.nih.gov/project-details/9196769
关键词：
AcuteAddressAdultAnaplasma phagocytophilumAreaArgasidaeArthralgiaBabesiaBacteriaBiologyBiteBlack-legged TickBorreliaBorrelia burgdorferiBorrelia miyamotoiClimateDiagnosisEhrlichiaEmerging Communicable DiseasesExhibitsExposure toFeverGeographic LocationsHealthHorizontal Disease TransmissionHospitalizationHourHumanImmunocompromised HostIncidenceInfectionInstitute of Medicine (U.S.)InvadedIxodesIxodidaeLaboratoriesLarvaLocationLyme DiseaseMaintenanceMeningoencephalitisMidwestern United StatesMyalgiaNew EnglandNymphOhioOrder SpirochaetalesOrnithodorosPopulationPrevalenceProteinsPublic HealthPublishingRelapsing FeverReportingResearch PersonnelRiskRiversSamplingSeminalSeriesSeroprevalencesSiteSpirochaetales InfectionsStagingSymptomsTick-Borne DiseasesTick-Borne Encephalitis VirusTick-Borne Encephalitis VirusesTick-Borne InfectionsTicksTimeVertical Disease TransmissionWidespread Diseasedifferential expressiondisorder preventionexposed human populationfeedingfield studylaboratory experimentland usepathogenrelapsing fever borreliatransmission processvector

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中文摘要
翻译
摘要 人类感染宫本疏螺旋体是美国新认识到的公共卫生威胁， 世界其他地方。Borrelia miyamotoi感染可能需要住院治疗，症状包括 高烧、关节和肌肉疼痛以及脑膜脑炎。B。miyamotoi是通过感染者的叮咬传播的。 硬蜱属蜱，但几乎没有人知道如何或在哪里细菌殖民其载体，或 传输的动力学。这项提议汇集了一个由疏螺旋体和蜱研究人员组成的专家小组， 将进行一系列的协同研究，这将大大扩展对B的理解。宫本传动 感染机制。
英文摘要
ABSTRACT Human infection by the spirochete Borrelia miyamotoi is a newly-recognized public health threat in the US and other parts of the world. Borrelia miyamotoi infection may require hospitalization, with symptoms that include high fever, joint and muscle pain, and meningoencephalitis. B. miyamotoi is spread by the bites of infected Ixodes spp. ticks, but almost nothing is known about how or where the bacterium colonizes its vector, or the dynamics of transmission. This proposal brings together an expert team of Borrelia and tick researchers, who will conduct a series of synergistic studies that will greatly expand understanding of B. miyamotoi transmission and infection mechanisms.
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  • 批准号：
    10597629
  • 项目类别：
  • 资助金额：
    $69.78万
  • 财政年份：
    2020
  • 负责人：
    Brian Stevenson
  • 依托单位：
    UNIVERSITY OF KENTUCKY
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