Genome Integrity Training Program

 描述(由申请人提供)：基因组完整性的控制正在成为人类疾病的一种关键潜在力量。纽约大学医学院基因组完整性培训计划的目的是通过提供一个强调基因组组织和功能基本原则的智力多样化和严谨的研究环境，使学生为基因组生物学的现代研究做好准备。具体地说，该计划旨在提供对调节染色体复制、修复、重组、表达和繁殖的分子机制的深入了解，并了解这些机制如何在组织内稳态以及细胞和生物健康的背景下发挥作用。拟议的计划是NYUSOM唯一支持以基因组完整性研究为主要目标的培训计划。对基因组组织和功能的深入理解将为学生在包括癌症、传染病和遗传病在内的影响人类健康的广泛领域的研究提供必要的基础。基因组完整性计划有来自NYUSOM五个系和纽约大学生物系的28名教师导师，他们拥有活跃的基因组完整性研究计划，使用了广泛的模式生物(细菌、病毒、酵母、苍蝇、蠕虫、小鼠和人类细胞)和技术(结构生物学、生物化学、细胞生物学、单分子分析、遗传学、 基因组学、蛋白质组学和系统分析)。基因组完整性的28名成员都是高生产率的科学家，拥有丰富的指导经验。在过去的10年里，他们总共指导了91名博士前实习生，其中大多数人都在追求科学和医学的职业生涯。该项目将得到NYUSOM的大力支持，并将受益于NYUSOM萨克勒研究所的开放研究生项目的积极招聘努力，这些项目吸引了高素质的研究生，包括未被充分代表的少数族裔学生。由于基因组完整性是一个不断扩大的领域，需要独特的智力和技术培训，我们预计该项目最终将有25-30名学生，因此我们要求每年提供6个博士前培训名额。基因组完整性方案的培训将包括：(A)首席研究员实验室的严格研究培训；(B)基因组功能、生物化学、遗传学和细胞生物学方面的广泛教育；(C)生物信息学和统计学、核细胞生物学和基因组完整性课程；(D)积极参加基因组完整性研讨会系列/报告/期刊俱乐部和年度务虚会；(E)有机会磨练赠款撰写和报告技能；(F)讨论小组和 侧重于科学道德行为问题的讲座和生物学毕业生的职业选择；(G)由一年级教师导师、研究顾问和论文委员会组成的三级导师制度。

 DESCRIPTION (provided by applicant): Control of genome integrity is emerging as a key underlying force in human disease. The aim of the Genome Integrity training program at the New York University School of Medicine is to equip students for modern research in genome biology by providing an intellectually diverse and rigorous research environment that emphasizes the basic principles of genome organization and function. Specifically, the program aims at providing in depth understanding of the molecular mechanisms regulating chromosomal replication, repair, recombination, expression, and propagation, and understanding how these mechanisms function in the context of tissue homeostasis and cellular and organismal fitness. The proposed program is the only program at the NYUSOM that supports training with research on genome integrity as its main objective. A deep understanding of genome organization and function will provide students with an essential underpinning for research in a broad range of areas that will impact human health including cancer and infectious and inherited diseases. The Genome Integrity Program has 28 faculty mentors from five departments at NYUSOM and the Biology department at NYU with active genome integrity research programs that use a use a broad range of model organisms (bacteria, virus, yeast, flies, worms, mouse, and human cells) and techniques (structural biology, biochemistry, cell biology, single molecule analysis, genetics, genomics, proteomics, and systems analysis). The 28 Genome Integrity members are highly productive scientists with extensive mentoring experience. In the last 10 years, they have mentored a total of 91 predoctoral trainees, most of whom, are pursuing careers in science and medicine. This program will receive strong support from the NYUSOM and will benefit from aggressive recruitment efforts by the open graduate programs at the Sackler Institute at the NYUSOM that have attracted high-caliber graduate students including underrepresented minority students. Since genome integrity is an expanding field requiring unique intellectual and technical training, and we anticipate an eventual steady state number of 25-30 students in the program, we are requesting 6 pre-doctoral training slots per year. Training in the Genome integrity program will include (a) rigorous research training in the principal investigator's laboratory; (b) broad education in genome function, biochemistry, genetics, and cell biology; (c) Bioinformatics and Statistics, Nuclear Cell Biology, and Genome Integrity courses; (d) active participation in the Genome Integrity seminar series/presentation/journal club, and an annual retreat; (e) opportunities to hone grant-writing and presentation skills; (f) discussion groups and lectures focusing on issues of ethical conduct in science and career options for biology graduates; and (g) a three-tiered mentoring system consisting of a first- year faculty mentor, research advisor, and thesis committee.