AFM based nanoscale IR Spectroscopy (AFM-IR) as a characterization platform for P

基于 AFM 的纳米级红外光谱 (AFM-IR) 作为 P 的表征平台

• 批准号: 8976271
• 负责人: Lynne S Taylor
• 金额: $ 48.15万
• 依托单位: ANASYS INSTRUMENTS CORPORATION
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2017-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8976271
• 关键词: Behavior; Chemicals; Complex; Crystal Formation; Crystallization; Data; Development; Dosage Forms; Drops; Drug Formulations; Evolution; Excipients; Film; Formulation; Health; Humidity; Lead; Lighting; Market Research; Measurement; Methods; Microscopic; Microtome - medical device; Monitor; Nanostructures; Pathway interactions; Performance; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Preparation; Process; Property; Quality Control; Regimen; Research; Resolution; Sampling; Scanning Probe Microscopes; Scientist; Side; Solubility; Solvents; Spectrum Analysis; Surface; Tablets; Techniques; Technology; Temperature; Testing; Time; Variant; amorphous solid; base; chemical property; design; evaporation; improved; infrared spectroscopy; insight; instrument; nanoscale; nanostructured; prevent; prototype; stability testing; tool

DESCRIPTION (provided by applicant): Anasys Instruments and Prof. Lynne Taylor of Purdue propose to develop nanoscale chemical characterization capabilities for drug formulation research. This project will build on successful Phase I research demonstrating feasibility of atomic force microscope-based infrared spectroscopy (AFM-IR) in pharmaceutical applications. This Phase II research will advance techniques for efficiently determining morphological and chemical properties of nanostructured drug formulations, leading to improvements in drug solubility. This project will overcome key limitations of existing characterization tools, includin the limitations of current AFM-IR technology. The proposed research will provide a critical new characterization tool for pharmaceutical research, will enable a large commercial and research market, and is expected to have significant downstream impacts on improving drug solubility and efficacy.

描述（由申请人提供）：Anasys Instruments 和普渡大学的 Lynne Taylor 教授提议开发用于药物制剂研究的纳米级化学表征能力。该项目将以成功的第一阶段研究为基础，展示基于原子力显微镜的红外光谱 (AFM-IR) 在制药应用中的可行性。这项二期研究将推进有效确定纳米结构药物制剂的形态和化学性质的技术，从而提高药物溶解度。该项目将克服现有表征工具的主要局限性，包括当前 AFM-IR 技术的局限性。拟议的研究将为药物研究提供一个重要的新表征工具，将形成一个巨大的商业和研究市场，并预计将对提高药物溶解度和功效产生重大的下游影响。

项目成果

Tailoring supersaturation from amorphous solid dispersions.

• DOI: 10.1016/j.jconrel.2018.04.014
• 发表时间: 2018-06-10
• 期刊: Journal of controlled release : official journal of the Controlled Release Society
• 作者: Li N;Taylor LS
• 通讯作者: Taylor LS