AFM based nanoscale IR Spectroscopy (AFM-IR) as a characterization platform for P

描述（由申请人提供）：ansys Instruments和普渡大学的Lynne Taylor教授提议开发纳米级化学表征能力，用于药物配方研究。该项目将建立在第一阶段成功的研究基础上，证明基于原子力显微镜的红外光谱（AFM-IR）在制药应用中的可行性。该二期研究将推进纳米结构药物配方的形态学和化学性质的有效测定技术，从而改善药物的溶解度。该项目将克服现有表征工具的关键限制，包括当前AFM-IR技术的限制。拟议的研究将为药物研究提供一个关键的新表征工具，将实现一个巨大的商业和研究市场，并有望对改善药物溶解度和功效产生重大的下游影响。

DESCRIPTION (provided by applicant): Anasys Instruments and Prof. Lynne Taylor of Purdue propose to develop nanoscale chemical characterization capabilities for drug formulation research. This project will build on successful Phase I research demonstrating feasibility of atomic force microscope-based infrared spectroscopy (AFM-IR) in pharmaceutical applications. This Phase II research will advance techniques for efficiently determining morphological and chemical properties of nanostructured drug formulations, leading to improvements in drug solubility. This project will overcome key limitations of existing characterization tools, includin the limitations of current AFM-IR technology. The proposed research will provide a critical new characterization tool for pharmaceutical research, will enable a large commercial and research market, and is expected to have significant downstream impacts on improving drug solubility and efficacy.