Synaptic mechanisms of coding transformations in auditory cortex
听觉皮层编码转换的突触机制
基本信息
- 批准号:8585050
- 负责人:
- 金额:$ 35.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-12-01 至 2015-11-30
- 项目状态:已结题
- 来源:
- 关键词:AnimalsAreaAuditoryAuditory areaCellsChildCodeDevelopmentGoalsHeartImpairmentLanguageLanguage DevelopmentLeadMeasuresMethodsModelingMusicNeuronsPhasePlayProcessPropertyRattusResearchRoleSensorySignal TransductionSpeechSpeech PerceptionSpeedStimulusStructureSynapsesTestingTimeTrainingWhole-Cell RecordingsWorkauditory pathwayawakeimprovedinnovationinsightpreferencepublic health relevancerehabilitation strategyrelating to nervous systemresearch studyresponsesensory integrationsoundspeech processingsynaptic inhibitionvoltage clamp
项目摘要
DESCRIPTION (provided by applicant): The long-term objective of this research is to understand how synaptic processing in auditory cortex transforms the neural representation of temporally structured sounds such as music and speech. The focus in this proposal is to test specific hypotheses about how synaptic inhibition transforms the representation of sound from a temporal code into a rate code. This transformation may support multi-sensory integration, because information from sensory areas with different dynamics may need to be converted into a common rate code to be meaningfully combined. The synaptic mechanisms underlying this process remain unknown. Aim 1 will test whether sustained rate-coded responses in auditory cortex are generated by a stimulus-specific decrease in synaptic inhibition. Aim 2 will test whether rate-coded responses to periodic stimuli are generated by a stimulus-specific decrease in synaptic inhibition. Aim 3 will test whether opponent processing of periodic stimuli occurs by a synaptic push-pull mechanism. To accomplish these aims, we will use whole-cell voltage clamp recordings from rat auditory cortical neurons to measure the excitation and inhibition evoked by optimal tones and periodic stimuli. These experiments will help to elucidate the synaptic mechanisms that transform how temporally structured sounds are encoded in auditory cortex. Because temporal structure provides information critical for speech perception, the synaptic processing of time-varying signals in auditory cortex is especially relevant to our understanding of the mechanisms underlying speech processing. The proposed studies will therefore contribute to our basic understanding of the cortical synaptic mechanisms involved in speech perception.
描述(由申请人提供):本研究的长期目标是了解听觉皮层中的突触处理如何转换时间结构化声音(如音乐和语音)的神经表征。在这个建议的重点是测试特定的假设,突触抑制如何将声音的表示从时间代码转换为速率代码。这种转换可以支持多感觉整合,因为来自具有不同动态的感觉区域的信息可能需要被转换成共同的速率代码以被有意义地组合。这一过程背后的突触机制仍然未知。目的1将测试听觉皮层中持续的速率编码反应是否由突触抑制的刺激特异性降低产生。目标2将测试对周期性刺激的速率编码反应是否由突触抑制的刺激特异性降低产生。目标3将测试是否对手处理周期性刺激发生的突触推拉机制。为了实现这些目标,我们将使用大鼠听觉皮层神经元的全细胞电压钳记录来测量由最佳音调和周期性刺激引起的兴奋和抑制。这些实验将有助于阐明突触机制,转换如何在听觉皮层编码的时间结构的声音。由于时间结构提供了言语感知的关键信息,听觉皮层中时变信号的突触处理与我们理解言语处理的机制特别相关。因此,拟议中的研究将有助于我们的基本了解皮层突触机制参与言语知觉。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael Wehr其他文献
Michael Wehr的其他文献
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{{ truncateString('Michael Wehr', 18)}}的其他基金
Circuit mechanisms underlying network disruption and temporal processing deficits in Alzheimer's
阿尔茨海默氏症网络中断和时间处理缺陷背后的电路机制
- 批准号:
10448151 - 财政年份:2022
- 资助金额:
$ 35.5万 - 项目类别:
Circuit mechanisms underlying network disruption and temporal processing deficits in Alzheimer's
阿尔茨海默氏症网络中断和时间处理缺陷背后的电路机制
- 批准号:
10633164 - 财政年份:2022
- 资助金额:
$ 35.5万 - 项目类别:
Circuit mechanisms underlying temporal processing in auditory cortex
听觉皮层时间处理的电路机制
- 批准号:
10058263 - 财政年份:2016
- 资助金额:
$ 35.5万 - 项目类别:
Synaptic mechanisms of coding transformations in auditory cortex
听觉皮层编码转换的突触机制
- 批准号:
8385566 - 财政年份:2010
- 资助金额:
$ 35.5万 - 项目类别:
Synaptic mechanisms of coding transformations in auditory cortex
听觉皮层编码转换的突触机制
- 批准号:
8196712 - 财政年份:2010
- 资助金额:
$ 35.5万 - 项目类别:
Synaptic mechanisms of coding transformations in auditory cortex
听觉皮层编码转换的突触机制
- 批准号:
8027457 - 财政年份:2010
- 资助金额:
$ 35.5万 - 项目类别:
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