Training & tools for Informationists to facilitate sharing of Next Generation Sequencing data.

 描述（由申请人提供）：“基因组”热潮的核心是对患者的遗传物质进行测序，即找出定义一个人的遗传组成的遗传成分（核苷酸）的特定序列。目前的“下一代测序”（NGS）产生了大量的数据。这些数据的一个重要方面是，为了让我们从中学习，其他科学家和研究人员需要比较不同的序列，因此个人研究人员应该将他们的数据上传到大型数据库，以便进行这种比较。我们建议创建3个在线模块，使研究人员更接近这种共享。首先是一个模块，教NGS研究的整个过程的整体视角。第二个是一个教的伦理问题，与这种研究，一般和分享，特别是。第三种是教授共享数据集本身所需的特定知识和技能。在每个模块中，将有一些例子显示正在教授的概念，使用户能够尝试概念，并使用户能够测试该模块的技能和知识。这些模块将通过Coursera作为集成模块向公众提供，并作为约翰霍普金斯韦尔奇医学图书馆生物信息学门户网站的单独组件。

 DESCRIPTION (provided by applicant): The heart of the "genomic" boom is the sequencing of patient's genetic material that is, finding out the specific sequences of genetic components (nucleotides) that defines a person's genetic makeup. Current "next generation sequencing" (NGS) produces huge amounts of data. An important aspect of such data is that for us to learn from them, other scientists and researchers need to compare different sequences, so individuals researchers should upload their data to large databases the enable such comparisons. We propose creating 3 online modules that move researchers closer to such sharing. First is a module that teaches an overall perspective of the entire process of NGS research. Second is one that teaches the ethical issues related to such research, in general and sharing, in particular. Third is one that teaches the specific knowledge and skills needed to share the datasets themselves. In each module, there will be examples that show the concepts being taught, that enable the user to try the concepts out, and that enable the user to be tested for skills and knowledge of that Module. The Modules will be made available to the public as integrated modules via Coursera and as individual components from the Johns Hopkins Welch Medical Library Bioinformatics Portal.