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Fluorescence microscopy for proposed research in the parent grant

Fluorescence microscopy for proposed research in the parent grant
用于母基金拟议研究的荧光显微镜
批准号：
9330633
负责人：
Maria Jasin
金额：
$17.69万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
项目状态：
已结题
起止时间：
2016-05-03 至 2021-04-30
来源：
https://reporter.nih.gov/project-details/9330633
关键词：
AddressAwardCellsChromosomesDNA lesionDNA replication forkDNA strand breakDevelopmentFertilityFluorescence MicroscopyFundingGenetic RecombinationGenomeGenomicsGerm CellsGrantHealthcareHumanLeadLesionMalignant NeoplasmsMalignant neoplasm of ovaryMeiotic RecombinationMitotic RecombinationMusResearchSomatic Cellfluorescence microscopelive cell imagingmalignant breast neoplasmmutantparent grantrepairedsegregationtumor

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中文摘要
翻译
在新资助的R35GM118175中，需要荧光显微镜进行研究。
英文摘要
Fluorescence microscopy is required for the research in the newly funded grant R35GM118175. This application is to allow the purchase a fluorescence microscope. The need for fluorescence microscopy is clear from our previous research funded by two R01 applications folded in the R35 award mechanism. More than half of the project description for R35GM118175 involves the analysis of mouse and cell mutants for proficiency in recombination: meiotic recombination, mitotic recombination (somatic cells), and replication fork protection, and live cell imaging will add a new dynamic.
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会议论文
Germline mutagenesis at meiotic double-strand breaks
Homology-directed repair: BRCA2 and RAD51 paralogs
Homology-directed repair: BRCA2 and RAD51 paralogs
Homology-directed repair: BRCA2 and RAD51 paralogs
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