Mentoring and Research in Self-Management for Health Promotion and Disease Prevention

项目摘要 这个K24应用程序是从一个职业生涯中期面向患者的研究人员与研究计划的重点是 了解弱势患者群体的信息需求，并开发基于信息的自我 管理工具，以促进健康和预防疾病。这个K24应用程序将建立在我目前的 成功的艾滋病毒研究组合，使我能够专注于长期目标，以扩大范围， 我的研究在我的职业生涯的下一个阶段，并提供保护的时间来指导下一代的 护理科学家在以病人为导向的研究（POR）。职业目标：1）成为一个国家和 结合生物行为学和信息学方法管理慢性疾病的国际领导者 疾病，主要侧重于与艾滋病毒有关的疾病，作为其他得不到充分服务的慢性病人群的模式; 2)在症状科学中获得分子遗传学方面的专业知识，以推进我的信息学研究计划 改善生物行为健康结果的策略; 3）将我的实验室改造成一个地方，区域， 国家和国际精准护理、生物行为健康干预卓越中心，以及 慢性病的自我管理;以及4）在POR中实施出色的自我管理培训计划， 管理和信息学为下一代的护士科学家。指导计划：使用 个性化的培训方法，其中包括对核心研究能力的需求评估和 正在进行的密集评估过程中，每个学员将通过一个个人 发展计划。他们还将参加几个针对其个人需要的培训模块， 例如，在一个实施例中，教学法;重点技能培训;应用，实践培训和团队管理;研究 传播;和赠款写作和研究发展。本提案的研究战略重点是 将生物标志物纳入我现有的研究，以增加两个艾滋病毒自我检测的速度和范围， 管理试验和两项艾滋病毒预防试验。我和我的学员将努力实现以下具体目标 目标。目的1：确定可能作为生物标志物的炎性细胞因子与 艾滋病毒感染者的症状负担。目的2：探索头发中皮质醇浓度的变化， 艾滋病毒高风险青年对长期慢性压力变化的激素反应。目标3： 进行试点研究，以评估“mLab App Plus”（包含使用双工）的可行性 艾滋病毒/梅毒即时检测。这一研究轨迹为加强行为健康研究带来了希望 通过阐明生物标志物作为我们现有试验中疗效预测因子的影响。此外，由于艾滋病毒/艾滋病 最近的研究表明，在医疗领域，拟议的工作与生活在美国的人， 艾滋病毒感染者和有感染艾滋病毒风险的人可以很容易地扩展到其他慢性疾病，从而为广泛的学习提供信息。 学员的机会。通过这些目标，我将为我的学员提供实践经验， 设计，并在自我管理研究领域进行POR，以符合他们的职业目标。

Project Summary This K24 application is from a mid-career patient-oriented researcher with a research program focused on understanding the information needs of vulnerable patient populations and developing informatics-based self- management tools to promote health and prevent disease. This K24 application will build on my current portfolio of successful HIV research and enable me to focus on long-term objectives to broaden the scope of my research in the next phase of my career and to provide the protected time to mentor the next generation of nurse scientists in patient-oriented research (POR). Career Objectives: 1) Become a national and international leader in combining bio-behavioral and informatics approaches for the management of chronic illness, largely focusing on HIV-related illnesses, as a model for other underserved chronic illness populations; 2) Gain expertise in molecular genetics in symptom science to advance my program of research on informatics strategies to improve bio-behavioral health outcomes; 3) Transform my laboratory into a local, regional, national, and international center of excellence for precision nursing, bio-behavioral health interventions, and self-management of chronic illness; and 4) Implement an outstanding training program in POR in self- management and informatics for the next generation of nurse scientists. Mentoring Plan: Using an individualized training approach, which includes a needs assessment of core research competencies and an ongoing intensive evaluation process, each mentee will monitor their progress through an Individual Development Plan (IDP). They will also participate in several training modules tailored to their individual needs, e.g., Didactics; Focused Skills Training; Applied, Hands-on Training & Team Management; Research Dissemination; and Grant Writing and Study Development. The Research Strategy of this proposal focuses on incorporating biomarkers into my existing studies to augment the pace and scope of two HIV self- management trials and two HIV prevention trials. My mentees and I will work to achieve the following specific aims. Aim 1: Determine the extent that inflammatory cytokines, which may serve as biomarkers, are related to symptom burden in persons living with HIV. Aim 2: Explore changes in cortisol concentrations in hair as a hormonal response to changes in chronic stress over time in youth who are at high-risk for HIV. Aim 3: Conduct a pilot study to assess the feasibility of the “mLab App Plus” which incorporates the use of the duplex HIV/syphilis point-of-care test. This research trajectory holds promise for enhancing behavioral health research by clarifying the influence of biomarkers as predictors of efficacy in our extant trials. Moreover, since HIV/AIDS research has recently been shown to yield dividends across medical fields, the proposed work with persons living with and at risk for HIV can easily be extended to other chronic illnesses, thus informing a wide array of learning opportunities for mentees. Through these aims, I will provide my mentees with practical experience in proposing, designing, and conducting POR in areas of self-management research that match their career goals.