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Mentoring and Research in Self-Management for Health Promotion and Disease Prevention

健康促进和疾病预防自我管理的指导和研究

基本信息

批准号：
10380063
负责人：
Rebecca Schnall
金额：
$ 4.29万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-04-17 至 2022-08-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10380063
关键词：
AIDS prevention AIDS/HIV problem Address Affect Age Area Award Behavioral Biological Biological Markers Bisexual Chronic Disease Chronic stress Collection Common Data Element Competence Data Collection Development Development Plans Discipline of Nursing Disease Epidemiology Etiology Evaluation Exercise Fatigue Frequencies Funding Gays Goals Grant HIV HIV prevention trial Hair Health Health Promotion Hormonal Human immunodeficiency virus test Hydrocortisone Hypothalamic structure Individual Inflammatory Informatics International Intervention Knowledge Laboratories Learning Measures Medical Mentors Mid-Career Clinical Scientist Award (K24)Minority Groups Modeling Molecular Genetics Monitor National Institute of Nursing Research Nature Needs Assessment Nurses Outcome Pain Pathway interactions Patient Outcomes Assessments Patient Self-Report Patients Persons Pharmaceutical Preparations Phase Pilot Projects Pituitary Gland Population Populations at Risk Principal Investigator Process Quality of life Randomized Clinical Trials Randomized Controlled Trials Regimen Reporting Research Research Personnel Risk Sample Size Sampling Science Scientist Self Management Stress Symptoms Syphilis Syphilis Serodiagnosis Testing Time Training Training Activity Training Programs Treatment Efficacy Viral Load result Work Writing Youth base behavioral health biobehavior career comorbidity cytokine design disorder prevention experience health disparity high risk improved innovation insight interdisciplinary collaboration international center knowledge base leadership development men mobile application mobile computing next generation patient oriented patient oriented research patient population peer point of care testing potential biomarker prevent programs research data dissemination response self testing skills skills training study population symptom management symptom science symptom self management tool young man

项目摘要

Project Summary This K24 application is from a mid-career patient-oriented researcher with a research program focused on understanding the information needs of vulnerable patient populations and developing informatics-based self- management tools to promote health and prevent disease. This K24 application will build on my current portfolio of successful HIV research and enable me to focus on long-term objectives to broaden the scope of my research in the next phase of my career and to provide the protected time to mentor the next generation of nurse scientists in patient-oriented research (POR). Career Objectives: 1) Become a national and international leader in combining bio-behavioral and informatics approaches for the management of chronic illness, largely focusing on HIV-related illnesses, as a model for other underserved chronic illness populations; 2) Gain expertise in molecular genetics in symptom science to advance my program of research on informatics strategies to improve bio-behavioral health outcomes; 3) Transform my laboratory into a local, regional, national, and international center of excellence for precision nursing, bio-behavioral health interventions, and self-management of chronic illness; and 4) Implement an outstanding training program in POR in self- management and informatics for the next generation of nurse scientists. Mentoring Plan: Using an individualized training approach, which includes a needs assessment of core research competencies and an ongoing intensive evaluation process, each mentee will monitor their progress through an Individual Development Plan (IDP). They will also participate in several training modules tailored to their individual needs, e.g., Didactics; Focused Skills Training; Applied, Hands-on Training & Team Management; Research Dissemination; and Grant Writing and Study Development. The Research Strategy of this proposal focuses on incorporating biomarkers into my existing studies to augment the pace and scope of two HIV self- management trials and two HIV prevention trials. My mentees and I will work to achieve the following specific aims. Aim 1: Determine the extent that inflammatory cytokines, which may serve as biomarkers, are related to symptom burden in persons living with HIV. Aim 2: Explore changes in cortisol concentrations in hair as a hormonal response to changes in chronic stress over time in youth who are at high-risk for HIV. Aim 3: Conduct a pilot study to assess the feasibility of the “mLab App Plus” which incorporates the use of the duplex HIV/syphilis point-of-care test. This research trajectory holds promise for enhancing behavioral health research by clarifying the influence of biomarkers as predictors of efficacy in our extant trials. Moreover, since HIV/AIDS research has recently been shown to yield dividends across medical fields, the proposed work with persons living with and at risk for HIV can easily be extended to other chronic illnesses, thus informing a wide array of learning opportunities for mentees. Through these aims, I will provide my mentees with practical experience in proposing, designing, and conducting POR in areas of self-management research that match their career goals.

项目摘要这个K24应用程序来自一位职业生涯中期的以患者为导向的研究人员，其研究计划侧重于了解弱势患者群体的信息需求，发展基于信息学的自我促进健康和预防疾病的管理工具。此K24应用程序将基于我的当前成功的艾滋病毒研究组合，使我能够专注于长期目标，扩大我在职业生涯下一阶段的研究，并提供有保护的时间来指导下一代以病人为中心的研究(POR)中的护理科学家。职业目标：1)成为国家级和将生物行为和信息学方法结合起来用于慢性病管理的国际领先者疾病，主要侧重于与艾滋病毒有关的疾病，作为其他服务不足的慢性病人群的榜样； 2)获得症状科学方面的分子遗传学专业知识，以推进我的信息学研究计划改善生物行为健康结果的策略；3)将我的实验室转变为本地、地区性、国家和国际精准护理、生物行为健康干预的卓越中心，以及慢性病的自我管理；4)在POR中实施出色的自我管理培训计划面向下一代护士科学家的管理和信息学。指导计划：使用个性化培训方法，其中包括对核心研究能力的需求评估和正在进行密集的评估过程，每个学员将通过个人监督他们的进展发展计划(IDP)。他们还将参加为其个人需求量身定做的几个培训模块，例如，教学论；重点技能培训；应用型实践培训和团队管理；研究传播；以及助学金写作和学习发展。本提案的研究策略重点是在我现有的研究中加入生物标记物，以增加两个HIV自我检测的速度和范围管理试验和两项艾滋病毒预防试验。我和我的学员将努力实现以下具体目标目标。目的1：确定可能作为生物标志物的炎性细胞因子在多大程度上与艾滋病毒携带者的症状负担。目的2：探讨头发中皮质醇浓度的变化随着时间的推移，艾滋病毒高危青年对慢性压力变化的荷尔蒙反应。目标3：进行一项试验性研究，以评估“mLab App Plus”的可行性，该应用程序结合了双层结构的使用艾滋病毒/梅毒护理点检测。这一研究轨迹为加强行为健康研究带来了希望通过阐明生物标志物在我们现有试验中作为疗效预测因子的影响。此外，由于艾滋病毒/艾滋病最近的研究表明，在医学领域产生了红利，拟议中的对生活在患有和面临艾滋病毒风险的人很容易扩展到其他慢性病，从而为广泛的学习提供信息学员的机会。通过这些目标，我将为我的导师提供求婚的实践经验，在符合其职业目标的自我管理研究领域设计和实施POR。