Dissemination of the WiseApp for Improving Health Outcomes Across Settings
传播 WiseApp 以改善跨环境的健康结果
基本信息
- 批准号:10685304
- 负责人:
- 金额:$ 38.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
PROJECT SUMMARY
Despite efforts to achieve UNAIDS 95-95-95 targets, marked deficits remain in antiretroviral therapy (ART) adherence
and viral suppression among persons living with HIV (PLWH). Gaps in HIV treatment success are particularly
pronounced in racial and ethnic minority populations and particularly among Latinos in the Northeast United States (US)
and the Caribbean. Progression of HIV disease and premature deaths among PLWH have been attributed foremost to
insufficient engagement in medical care and adherence to HIV treatment regimens. Timely access to ART and subsequent
sustained ART adherence are central to therapeutic success and critical determinants of long-term health outcomes (e.g.,
viral suppression) in PLWH. To that end, our team conducted extensive formative work (CDC:U01PS003715) with
racial/ethnic minority PLWH and their providers to identify the content, features, functionalities, and interface of a mobile
app to improve health outcomes, including ART adherence. Building on the findings, the Agency for Healthcare Research
and Quality (AHRQ) provided support to build this app and integrate it with a smart pill box (CleverCap) enabling PLWH
to self-monitor their medication adherence in real-time. This innovative tool, the WiseApp, supersedes current approaches
to ART adherence using a self-management mobile app linked to an electronic pill box and is currently being evaluated in
a randomized controlled trial (RCT) (NCT03205982) in New York City (NYC). At the same time, there is a strong need
for the development and testing of self-management interventions for Spanish speaking Latino PLWH since they are the
largest and fastest growing ethnic minority group in the US and are disproportionately affected by HIV. We propose to
test the transferability of the WiseApp to Latinos in the US and the Dominican Republic (DR) by translating and
culturally adapting it and conducting a multi-site RCT to assess its efficacy. The proposed project is aligned with AHRQ
Special Emphasis Notice NOT-HS-16-015 and will use health information technology to facilitate the collection and use
of patient-reported outcomes including medication adherence, quality of life, and symptom burden. The study will address
the following specific aims: 1. Adapt and ensure the usability of the WiseApp for Spanish speaking PLWH. 2. Conduct a
RCT to assess the efficacy and sustainability of the WiseApp compared to a usual care control in a transnational sample
of Spanish speaking PLWH at 3, 6, and 12 months. 3. Identify multi-level barriers and facilitators to the widespread
implementation of the WiseApp. A mixed-methods, multi-stakeholder process evaluation of the WiseApp will be
conducted guided by the Consolidated Framework for Implementation Research. The proposed project builds on our
team's robust preliminary data and capitalizes on the strong linkage between Columbia University and Clínica de Familia
in the DR. This project's significance is further enhanced by capitalizing on the strong presence of Latinos in the
Washington Heights neighborhood of NYC, the disproportionately high rates of HIV in the DR, and the patterns of
geographic mobility between NYC and the DR. Importantly, our study focuses on AHRQ Priority Populations,
specifically chronically ill, inner-city, low-income, and racial/ethnic minority persons.
项目摘要
尽管为实现艾滋病规划署1995 - 1995 - 1995年的目标作出了努力,但在坚持抗逆转录病毒疗法方面仍然存在明显不足
艾滋病毒感染者(PLWH)的病毒抑制。艾滋病毒治疗成功方面的差距尤其
在种族和少数民族人口中,特别是在美国东北部的拉丁美洲人中,
和加勒比艾滋病毒感染者的病情恶化和过早死亡主要归因于
对医疗保健和坚持艾滋病毒治疗方案的参与不足。及时获得抗逆转录病毒治疗,
持续的ART依从性是治疗成功的核心和长期健康结果的关键决定因素(例如,
病毒抑制)。为此,我们的团队进行了广泛的形成性工作(CDC:U01PS003715),
种族/少数民族PLWH及其供应商,以确定移动的的内容,特点,功能和界面
应用程序来改善健康结果,包括ART依从性。基于这些发现,医疗保健研究机构
和质量(AHRQ)提供了支持,以建立这个应用程序,并将其与智能药盒(CleverCap)集成,使PLWH
实时自我监测他们的药物依从性。这一创新工具WiseApp取代了当前的方法
使用链接到电子药盒的自我管理移动的应用程序,
在纽约市(NYC)进行的一项随机对照试验(RCT)(NCT 03205982)。与此同时,
为讲西班牙语的拉丁裔艾滋病毒携带者制定和测试自我管理干预措施,因为他们是
美国最大和增长最快的少数族裔群体,受艾滋病毒影响不成比例。我们建议
测试WiseApp在美国和多米尼加共和国(DR)的拉丁美洲人的可转移性,
文化适应它,并进行多地点随机对照试验,以评估其疗效。拟议项目与AHRQ保持一致
特别强调通知NOT-HS-16 - 015,并将利用卫生信息技术促进收集和使用
患者报告的结果,包括药物依从性,生活质量和症状负担。该研究将探讨
具体目标如下:1.调整并确保WiseApp适用于讲西班牙语的艾滋病毒携带者。2.进行
在跨国样本中评估WiseApp与常规护理对照相比的疗效和可持续性的RCT
在第3、6和12个月时讲西班牙语的PLWH。3.确定多层次的障碍和促进因素,
使用WiseApp。将对WiseApp进行混合方法、多利益相关方流程评估,
在实施研究综合框架的指导下进行。拟议项目建立在我们的
研究小组的初步数据,并利用了哥伦比亚大学和Clínica de Familia之间的紧密联系
这个项目的重要性进一步加强了利用拉丁美洲人在
纽约市的华盛顿高地社区,DR中不成比例的高艾滋病毒感染率,以及
重要的是,我们的研究重点是AHRQ优先人群,
特别是慢性病患者、市中心居民、低收入者和少数种族/民族人士。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A randomized controlled trial of the dissemination of an mHealth intervention for improving health outcomes: the WiseApp for Spanish-speakers living with HIV study protocol.
- DOI:10.1186/s12889-023-17538-y
- 发表时间:2024-01-17
- 期刊:
- 影响因子:4.5
- 作者:Olaya, Felix;Brin, Maeve;Caraballo, Pamela Baez;Halpern, Mina;Jia, Haomiao;Ramirez, Sergio Ozoria;Padilla, Janeth Juarez;Stonbraker, Samantha;Schnall, Rebecca
- 通讯作者:Schnall, Rebecca
Understanding Physical Activity Determinants in an HIV Self-Management Intervention: Qualitative Analysis Guided by the Theory of Planned Behavior.
- DOI:10.2196/47666
- 发表时间:2023-09-14
- 期刊:
- 影响因子:2.2
- 作者:
- 通讯作者:
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Rebecca Schnall其他文献
Rebecca Schnall的其他文献
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{{ truncateString('Rebecca Schnall', 18)}}的其他基金
Dissemination of the WiseApp for Improving Health Outcomes Across Settings
传播 WiseApp 以改善跨环境的健康结果
- 批准号:
10490284 - 财政年份:2021
- 资助金额:
$ 38.53万 - 项目类别:
mChoice: Improving PrEP Uptake and Adherence among Minority MSM through Tailored Provider Training and Adherence Assistance in Two High Priority Settings
mChoice:通过在两个高度优先的环境中提供定制的提供者培训和依从性援助,提高少数族群 MSM 的 PrEP 接受度和依从性
- 批准号:
10324998 - 财政年份:2021
- 资助金额:
$ 38.53万 - 项目类别:
mChoice: Improving PrEP Uptake and Adherence among Minority MSM through Tailored Provider Training and Adherence Assistance in Two High Priority Settings
mChoice:通过在两个高度优先的环境中提供定制的提供者培训和依从性援助,提高少数族群 MSM 的 PrEP 接受度和依从性
- 批准号:
10488047 - 财政年份:2021
- 资助金额:
$ 38.53万 - 项目类别:
mChoice: Improving PrEP Uptake and Adherence among Minority MSM through Tailored Provider Training and Adherence Assistance in Two High Priority Settings
mChoice:通过在两个高度优先的环境中提供定制的提供者培训和依从性援助,提高少数族群 MSM 的 PrEP 接受度和依从性
- 批准号:
10663097 - 财政年份:2021
- 资助金额:
$ 38.53万 - 项目类别:
Dissemination of the WiseApp for Improving Health Outcomes Across Settings
传播 WiseApp 以改善跨环境的健康结果
- 批准号:
10290733 - 财政年份:2021
- 资助金额:
$ 38.53万 - 项目类别:
Mentoring and Research in Self-Management for Health Promotion and Disease Prevention
健康促进和疾病预防自我管理的指导和研究
- 批准号:
10380063 - 财政年份:2019
- 资助金额:
$ 38.53万 - 项目类别:
Mentoring and Research in Self-Management for Health Promotion and Disease Prevention
健康促进和疾病预防自我管理的指导和研究
- 批准号:
9917843 - 财政年份:2019
- 资助金额:
$ 38.53万 - 项目类别:
The Wise App Trial for Improving Health Outcomes in PLWH
用于改善 PLWH 健康结果的 Wise 应用试验
- 批准号:
10013220 - 财政年份:2016
- 资助金额:
$ 38.53万 - 项目类别:
Use of mHealth Technology for Supporting Symptom Management in Underserved Persons Living with HIV
使用移动医疗技术支持服务不足的艾滋病毒感染者的症状管理
- 批准号:
8902295 - 财政年份:2015
- 资助金额:
$ 38.53万 - 项目类别:
Video Information Provider for HIV-Associated Non-AIDS (VIP-HANA) Symptoms
HIV 相关非艾滋病 (VIP-HANA) 症状视频信息提供者
- 批准号:
9111067 - 财政年份:2015
- 资助金额:
$ 38.53万 - 项目类别:
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Dissemination of the WiseApp for Improving Health Outcomes Across Settings
传播 WiseApp 以改善跨环境的健康结果
- 批准号:
10490284 - 财政年份:2021
- 资助金额:
$ 38.53万 - 项目类别:
Dissemination of the WiseApp for Improving Health Outcomes Across Settings
传播 WiseApp 以改善跨环境的健康结果
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10290733 - 财政年份:2021
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