The TEEN Study: The Impact of Adolescent Drinking on Connectivity in the Brain

描述（由申请人提供）：本申请描述了OHSU网站对题为“跟踪乙醇对神经发育的影响”（TEEN）的联盟的数据收集工作的贡献，以及OHSU网站对研究酒精如何影响发育中大脑的功能连接以及连接模式是否可用于预测酒精中毒风险的具体关注。众所周知，青春期是大脑戏剧性成熟的时期，伴随着执行能力、社会功能和智力的提高。 情绪调节最近，人们已经认识到，大脑的功能网络动态，有助于这些改善，也显着改变了青春期。这段可塑性增强的时期与对神经毒性酒精影响的更大脆弱性相吻合，例如青春期的重度酒精暴露可能导致神经回路正常发生的成熟中断。为了研究这个问题，青少年联盟的方法将是不成比例地招募那些基于个性特征而具有较高饮酒风险的人。选择这种方法是为了确保有足够数量的人在本项目期间从不使用过渡到使用，并确保有足够数量的人已经在饮酒，从而使横截面比较能够补充纵向研究。使用序贯队列设计，TEEN联盟将招募750名青年，分为三个年龄段：12-15岁，15-18岁和18-21岁，每个站点招募并跟踪150名青年。将纳入一组标准化的神经影像学、认知和临床评估，并在基线和3次1年随访时进行评估。OHSU网站提案的主要目的是了解酒精对青少年大脑回路的影响，并使用多模式整合开发青少年大脑网络中与风险相关的异常。了解与酒精中毒风险增加相关的神经表型以及酒精对青少年大脑神经连接的潜在有害影响，可以帮助制定旨在减少青少年饮酒行为的有针对性的策略。

DESCRIPTION (provided by applicant): This application describes the contribution of the OHSU site to the data collection efforts of the consortium entitled, Tracking Ethanol's Effects on Neurodevelopment (TEEN), and the specific focus of the OHSU site on examining how alcohol impacts functional connectivity in the developing brain and whether connectivity patterns can be used to predict risk for alcoholism. It is well-established that adolescence is a time of dramatic maturation in the brain, paralleled by improvements in executive abilities, social functioning, and emotional regulation. More recently, it has become appreciated that functional network dynamics of the brain, subserving these improvements, also dramatically change over the adolescent years. This period of heightened plasticity coincides with greater vulnerability to neurotoxic alcohol effects, such that heavy alcohol exposure during adolescence may result in disruption to normally occurring maturation of neural circuitry. To examine this question, the approach of the TEEN consortium will be to disproportionately recruit individuals who are at elevated risk for alcohol use, based on personality features. This approach was chosen to ensure sufficient numbers of individuals who will transition from no use to use within the duration of this project, and also ensures sufficient numbers of individuals who are already drinking thereby enabling cross-sectional comparisons to complement the longitudinal studies. Using a sequential cohort design, the TEEN consortium will recruit 750 youth, stratified across three age-ranges: 12-15 years, 15-18 years, and 18-21 years, with each site recruiting and following 150 youth. A standardized set of neuroimaging, cognitive, and clinical assessments will be included and administered at baseline and at three one-year follow-ups. The major aims of the OHSU site proposal are toward understanding the influence of alcohol on adolescent brain circuitry and at delineating risk-related abnormalities in developing adolescent brain networks using multi-modal integration. Understanding the neural phenotypes associated with increased risk for alcoholism and the potentially deleterious impact of alcohol on the neural connections in the adolescent brain could aid in the development of targeted strategies aimed at reducing adolescent alcohol drinking behaviors.