The TEEN Study: The Impact of Adolescent Drinking on Connectivity in the Brain

描述(由申请人提供)：本申请描述了OHSU网站对名为跟踪乙醇对神经发育的影响(TEND)的财团数据收集工作的贡献，以及OHSU网站的具体重点，即检查酒精如何影响发育中大脑的功能连接，以及连接模式是否可用于预测酒精中毒的风险。众所周知，青春期是大脑戏剧性成熟的时期，同时执行能力、社交功能和 情绪调节。最近，人们认识到，大脑的功能网络动态，伴随着这些改进，也在青春期发生了戏剧性的变化。这段可塑性增强的时期恰逢更容易受到神经毒性酒精影响的影响，因此青春期接触大量酒精可能会导致正常发生的神经回路成熟中断。为了研究这个问题，青少年联盟的方法将是根据人格特征，不成比例地招募酒精使用风险较高的个人。选择这一方法是为了确保在该项目期间有足够数量的人从无用转为使用，并确保有足够数量的人已经在喝酒，从而能够进行横断面比较，以补充纵向研究。采用顺序队列设计，青少年联盟将招募750名年轻人，按三个年龄段进行分层：12-15岁、15-18岁和18-21岁，每个站点招募并跟踪150名年轻人。将包括一套标准化的神经成像、认知和临床评估，并在基线和三次为期一年的随访中进行。OHSU网站建议的主要目的是了解酒精对青少年大脑电路的影响，并利用多模式整合来描绘青少年大脑网络发育过程中与风险相关的异常。了解与酒精中毒风险增加相关的神经表型以及酒精对青少年大脑神经连接的潜在有害影响，有助于制定旨在减少青少年饮酒行为的有针对性的策略。

DESCRIPTION (provided by applicant): This application describes the contribution of the OHSU site to the data collection efforts of the consortium entitled, Tracking Ethanol's Effects on Neurodevelopment (TEEN), and the specific focus of the OHSU site on examining how alcohol impacts functional connectivity in the developing brain and whether connectivity patterns can be used to predict risk for alcoholism. It is well-established that adolescence is a time of dramatic maturation in the brain, paralleled by improvements in executive abilities, social functioning, and emotional regulation. More recently, it has become appreciated that functional network dynamics of the brain, subserving these improvements, also dramatically change over the adolescent years. This period of heightened plasticity coincides with greater vulnerability to neurotoxic alcohol effects, such that heavy alcohol exposure during adolescence may result in disruption to normally occurring maturation of neural circuitry. To examine this question, the approach of the TEEN consortium will be to disproportionately recruit individuals who are at elevated risk for alcohol use, based on personality features. This approach was chosen to ensure sufficient numbers of individuals who will transition from no use to use within the duration of this project, and also ensures sufficient numbers of individuals who are already drinking thereby enabling cross-sectional comparisons to complement the longitudinal studies. Using a sequential cohort design, the TEEN consortium will recruit 750 youth, stratified across three age-ranges: 12-15 years, 15-18 years, and 18-21 years, with each site recruiting and following 150 youth. A standardized set of neuroimaging, cognitive, and clinical assessments will be included and administered at baseline and at three one-year follow-ups. The major aims of the OHSU site proposal are toward understanding the influence of alcohol on adolescent brain circuitry and at delineating risk-related abnormalities in developing adolescent brain networks using multi-modal integration. Understanding the neural phenotypes associated with increased risk for alcoholism and the potentially deleterious impact of alcohol on the neural connections in the adolescent brain could aid in the development of targeted strategies aimed at reducing adolescent alcohol drinking behaviors.