Timing Effects of Heavy Alcohol Initiation on Adolescent Neurodevelopment

重度酒精开始对青少年神经发育的时间影响

• 批准号: 8515884
• 负责人: Bonnie J Nagel
• 金额: $ 29.51万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-20 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8515884
• 关键词: 14 year old; Addictive Behavior; Address; Adolescence; Adolescent; Affect; Age; Age of Onset; Alcohol consumption; Alcohol or Other Drugs use; Alcoholism; Alcohols; Behavior; Biological Assay; Brain; Brain region; Characteristics; Cognition; Decision Making; Development; Dose; Drug usage; Family history of; Functional Magnetic Resonance Imaging; Functional disorder; Heavy Drinking; Hormonal; Incidence; Individual; Intervention; Interview; Life; Limbic System; Link; Longevity; Measures; Memory; Monitor; Moods; National Institute on Alcohol Abuse and Alcoholism; Neurocognition; Neurocognitive; Neuropsychological Tests; Participant; Pattern; Performance; Personality; Predictive Value; Prefrontal Cortex; Prospective Studies; Puberty; Recording of previous events; Recruitment Activity; Relative (related person); Research; Research Design; Risk; Risk Factors; Risk-Taking; Sampling; Sex Characteristics; Short-Term Memory; Staging; Strategic Planning; Stress; Structure; System; Techniques; Teenagers; Temperament; Testing; Time; Youth; abstracting; addiction; alcohol effect; alcohol exposure; alcohol use disorder; alcohol use initiation; base; binge drinking; brain volume; critical period; design; discounting; drinking; drinking behavior; early alcohol abuse; early alcohol use; executive function; follow-up; heavy drinking during adolescence; high risk; high risk behavior; neurodevelopment; neuroimaging; neuropsychological; neurotoxic; response; sex; white matter

Abstract: Adolescence is a developmental period during which individuals engage in risk-taking behavior and are likely to initiate use of alcohol or other drugs. Past research suggests a strong correlation between early age of onset of alcohol use and a heightened vulnerability to addiction later in life. Adolescence is also a time of considerable neuromaturation, particularly in frontal brain regions thought to subserve higher level cognition, such as decision making and inhibition. Heavy alcohol use during these critical periods of brain development may permanently disrupt the course of maturation, resulting in long-term deficits in these functions and thereby increasing the risk of subsequent substance use behavior. The proposed R01 project is designed to prospectively and longitudinally examine the influence of developmental stage on the effects of alcohol on adolescent cognition, brain functioning, and brain structure, using neuroimaging and neuropsychological testing techniques. This project will examine neuropsychological performance during tests of executive functioning, brain functioning during executive and risk taking fMRI tasks, brain structure in prefrontal and limbic regions, and frontostriatal white matter integrity in 250 at-risk, non-using 12-14-year-old youth (based on family history of alcoholism). We hypothesize that youth who drink in adolescence will show abnormalities on these measures compared to developmentally-matched non-drinking youth, and that youth who initiate heavy drinking earlier in puberty will show greater abnormalities than teens that initiate heavy drinking later in development. This prospective study will answer critical questions about how developmental timing of adolescent heavy alcohol use initiation affects the developing brain.

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