National Consortium on Alcohol and Neurodevelopment in Adolescence: OHSU

国家酒精与青春期神经发育联盟：OHSU

• 批准号: 9383886
• 负责人: Bonnie J Nagel
• 金额: $ 57.67万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9383886
• 关键词: Abstinence; Acute; Address; Adolescence; Adolescent; Adolescent Development; Adult; Adverse effects; Affective; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcohols; Anisotropy; Area; Behavior; Behavior assessment; Behavioral; Biological; Brain; Childhood; Chronic; Clinical assessments; Cognitive; Collection; Corpus striatum structure; Cox Proportional Hazards Models; Data; Development; Diffusion Magnetic Resonance Imaging; Dose; Ecological momentary assessment; Education; Employment; Environment; Equipment and supply inventories; Event; Foundations; Functional Magnetic Resonance Imaging; Health; Heart Rate; Heavy Drinking; Human; Individual; Legal; Life; Magnetic Resonance Imaging; Mediating; Mental Health; Mental disorders; Modeling; Monitor; Neuraxis; Neurobiology; Neurocognitive; Neuropsychology; Outcome; Parietal; Participant; Pattern; Phase; Post-Traumatic Stress Disorders; Prefrontal Cortex; Prevention program; Psychosocial Factor; Public Policy; Recovery; Regulation; Reporting; Research Project Grants; Rest; Rewards; Risk; Sampling; Sex Characteristics; Sex Differentiation; Site; Statistical Models; Stress; Structure; Substance Use Disorder; Symptoms; Teenagers; Variant; Visit; Work; acronyms; age effect; alcohol consequences; alcohol effect; alcohol expectancy; alcohol exposure; alcohol measurement; alcohol risk; alcohol use disorder; binge drinking; cognitive control; cognitive development; cognitive testing; cohort; depressive symptoms; drinking; drinking onset; emerging adult; executive function; experience; externalizing behavior; genetics of alcoholism; gray matter; information processing; longitudinal design; mobile application; multimodality; neural circuit; neurodevelopment; neuroimaging; neurotoxic; psychobiologic; psychologic; relating to nervous system; resilience; response; sex; twelfth grade; underage drinking; white matter; young adult

PROJECT SUMMARY During young adulthood, drinking dramatically increases, with binge-level drinking peaking at age 22 and nearly half of individuals reporting binge-level alcohol use2. Frequent binge alcohol use during the protracted neuromaturation spanning into the mid-20s may result in greater brain and cognitive effects than similar alcohol use in later adulthood. In response to RFA-AA-17-003, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence second phase (NCANDA-2) to determine the predictors and effects of heavy adolescent alcohol use in adolescence and young adulthood. To achieve this, the OHSU site of NCANDA-2 will continue to follow a cohort of 150 Portland-area (n=831 across all 5 sites) participants (ages 12-21 at baseline first visit) to acquire the necessary data to advance our understanding of adolescent development and the effects of alcohol use during adolescence on the adult brain. NCANDA-2 will use multimodal neuroimaging, cognitive testing, behavioral assessment, biospecimen collection, and ecological momentary assessment. The examination of alcohol consequences will focus on structural and functional maturation of brain areas that actively develop during adolescence, are involved in psychological regulation, respond to rewards, and appear vulnerable to neurotoxic effects of alcohol. In addition, the OHSU site will collaborate with the Duke and USCD sites to study recovery of these abnormalities. Specifically, we will examine the degree to which targeted heavy drinking related neurocognitive and brain integrity deficits remit over 4 weeks of monitored abstinence. Sex differences in development, alcohol use patterns, impact of alcohol use on the brain, and sex-differentiating psychosocial factors (e.g., depression symptoms) will be considered in analyses. With the additional longitudinal data provided by this renewal, we will determine the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent or young adult at elevated risk for an alcohol use disorder.

项目摘要 在年轻的成年期，饮酒量急剧增加，22岁时达到顶峰， 近一半的人报告酗酒2.长期饮酒期间频繁酗酒 神经成熟跨越到20多岁中期可能会导致更大的大脑和认知效果比类似的 成年后的酒精使用作为对RFA-AA-17-003的回应，本申请提出了一项研究项目 国家酒精和青少年神经发育联盟第二阶段（NCANDA-2） 以确定青少年在青春期和青年期大量饮酒的预测因素和影响。 为了实现这一目标，NCANDA-2的OHSU研究中心将继续随访150名波特兰地区（n=831 所有5个研究中心）参与者（基线首次访视时年龄为12-21岁），以获取必要的数据， 了解青少年的发展和青少年时期饮酒对成年人大脑的影响。 NCANDA-2将使用多模式神经成像、认知测试、行为评估、生物样本 收集和生态瞬时评估。对酒精后果的审查将集中在 在青春期活跃发育的大脑区域的结构和功能成熟， 心理调节，对奖励做出反应，似乎容易受到酒精的神经毒性影响。在 此外，OHSU工厂将与杜克和USCD工厂合作，研究这些 异常具体来说，我们将研究有针对性的大量饮酒相关的神经认知的程度， 和大脑完整性缺陷缓解超过4周的监控禁欲。发展中的性别差异， 酒精使用模式、酒精使用对大脑的影响，以及性别区分的心理社会因素（例如， 抑郁症状）将在分析中考虑。通过本研究提供的额外纵向数据， 更新，我们将确定酒精暴露对青少年发展轨迹的影响 人类大脑，并确定预先存在的心理生物学脆弱性，可能会使青少年或年轻人 酒精使用障碍风险升高的成年人。