Sex-specific trajectories of neurobiological maturation during adolescence

青春期神经生物学成熟的性别特异性轨迹

• 批准号: 8606248
• 负责人: Bonnie J Nagel
• 金额: $ 19.25万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-18 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8606248
• 关键词: 15 year old; Adolescence; Adolescent; Adult; Affective; Age; Back; Behavior; Behavioral; Biological Assay; Brain; Brain region; Characteristics; Cognition; Cognitive; Corpus striatum structure; Coupled; Cross-Sectional Studies; Decision Making; Development; Developmental Process; Diffusion Magnetic Resonance Imaging; Disease; Down-Regulation; Emotional; Emotions; Esthesia; Female; Female Adolescents; Fiber; Functional Magnetic Resonance Imaging; Future; Gonadal Hormones; Hormonal; Hormones; Incidence; Individual; Individual Differences; Knowledge; Longitudinal Studies; Magnetic Resonance Imaging; Male Adolescents; Mediating; Mediator of activation protein; Mental disorders; Moods; Motivation; Neurobiology; Neurocognitive; Nucleus Accumbens; Parietal; Pathway interactions; Personality; Personality Assessment; Personality Traits; Play; Prefrontal Cortex; Prevention; Process; Psychopathology; Puberty; Regulation; Rest; Rewards; Risk; Role; Serum; Sex Characteristics; Short-Term Memory; Social Behavior; Social Functioning; Structure; System; Time; Ursidae Family; Variant; Work; age related; base; cognitive control; cohort; executive function; improved; longitudinal design; male; motivated behavior; neurodevelopment; neuroimaging; public health relevance; relating to nervous system; resilience; segregation; sex; skills; treatment strategy; white matter

DESCRIPTION (provided by applicant): It is well-established that adolescence is a time of dramatic neuromaturation, paralleled by improvements in cognition, social functioning, and emotional regulation. In addition, cross-sectional studies have demonstrated that rising gonadal hormone levels associated with puberty influence emotional and appetitive processing and limbic brain structure and functioning. Given the rise in psychopathology during adolescence, the hormonal activation of limbic brain regions during puberty, coupled with the immaturity of sexually dimorphic prefrontal regulatory systems, may contribute to heightened adolescent vulnerability for psychopathology in a sex- specific manner; however, little longitudinal work has been done to fully explore this notion. To that end, this study will longitudinally follow 120 healthy, 12-15-year-old male and female adolescents after one year with a rich, multimodal neuroimaging and behavioral characterization. This assessment will include functional neuroimaging during working memory and decision making, resting state functional neuroimaging, diffusion tensor imaging, neurocognitive assessment, mood/behavior/personality assessment, and serum hormone assays. Using a multi-modal longitudinal design, we aim to better understand sex-specific structural and functional neuromaturation of the brain during adolescence and to explore associations with gonadal hormones, cognition, and behavior. Increased understanding of these relationships may help to explain sex- specific vulnerability, better dissociate hormonally influenced developmental pathways from those that are not, elucidate individual characteristics conferring risk and resilience, and may ultimately permit the development of targeted treatment strategies aimed at reducing adolescent psychopathology.

描述(由申请人提供)：众所周知，青春期是一个戏剧性的神经成熟时期，伴随着认知、社会功能和情绪调节的改善。此外，横断面研究表明，与青春期相关的性腺激素水平上升会影响情绪和食欲的处理以及边缘脑的结构和功能。鉴于青春期精神病理学的兴起，青春期边缘脑区荷尔蒙的激活，加之性二态前额叶调节系统的不成熟，可能会导致青少年以性别特有的方式更容易患精神病理学；然而，几乎没有做过纵向工作来充分探索这一概念。为此，这项研究将对120名健康的、12-15岁的男女青少年进行纵向跟踪，一年后进行丰富的、多模式的神经成像和行为表征。这项评估将包括工作记忆和决策过程中的功能神经成像，静息状态功能神经成像，扩散张量成像，神经认知评估，情绪/行为/个性评估，以及血清激素分析。使用多模式纵向设计，我们的目标是更好地了解青春期大脑特定性别的结构和功能神经成熟，并探索与性腺激素、认知和行为的关系。增加对这些关系的理解可能有助于解释特定性别的脆弱性，更好地将受荷尔蒙影响的发育途径与不受激素影响的发育途径分开，阐明赋予风险和韧性的个体特征，并最终可能允许开发旨在减少青少年精神病理的有针对性的治疗策略。