National Consortium on Alcohol and Neurodevelopment in Adolescence: OHSU

项目总结 众所周知，在青春期开始过量饮酒会扰乱典型的神经发育模式， 增加患酒精使用障碍(AUD)的风险，并加速成年后的更年期过程。 响应RFA-AA-21-007，本申请提出了国家联合体的研究项目站点 关于酒精与青春期-成年期神经发育(NCANDA-A)未来5年的研究 NCANDA招募的基准线上的多样化社区样本，主要是无饮酒者和低饮酒者 当年龄在12-21岁时，并且在过去8年中跟踪了5个站点(N=831；保留率为93%)。 监测涉及每年获得的多模式神经成像(磁共振成像、DTI、静息状态功能磁共振、任务功能磁共振)， 认知、临床、行为和生物数据，亲自收集或通过计算机和我们的移动设备远程收集 应用程序。这些措施现在将得到新的先进的神经成像和睡眠和体格检查的补充 活动跟踪。这一队列顺序设计独特地将NCANDA-A定位为量化瞬变或耐久 酒精相关障碍在特定的青少年和成人早期神经系统发育轨迹和 功能伴随词。 NCANDA-A提出了四个联合体范围的具体目标和两个专业项目目标。在目标1中，NCANDA-A 将调查青春期和成年初期过度饮酒对 认知表现、大脑结构和功能的后续发展轨迹，以及 精神变态学。目标2的分析将确定神经发育模式，描述 酒精对大脑结构和功能的影响在酗酒后的戒酒过程中会消失或持续。目标3 将部署数据驱动分析，以确定青少年的生物、环境和行为因素(例如，年龄 饮酒开始)，这预示着个人在成年早期过度饮酒。在AIM 4中，NCANDA-A 将量化COVID大流行对生活压力以及社会、情感和经济福祉的影响，并 它们与酒精使用模式的关系。在目标5中，SRI和匹兹堡站点将确定 酒精使用、睡眠和心脏功能的模式。在目标6中，加州大学圣地亚哥分校、杜克大学和OHSU网站将确定 短期(即4周)停止饮酒在多大程度上导致精神疾病的显著改善 认知、情感、睡眠和静息心率，以及逆转不利的结构和功能脑影响 经常酗酒。对于每个目标，发育中的性别差异，酒精使用模式和历史， 酒精使用对大脑的影响，以及性别分化的心理社会因素将被测试。 随着在这次更新中收集到成年早期的纵向数据，NCANDA-A将提供新的 向公众提供有关青少年饮酒对成年人机能的持久和短暂影响的信息 发现链接这些动态过程的要素和机制，并确定可更改的风险因素。

PROJECT SUMMARY Initiating excessive alcohol drinking during adolescence is known to disturb typical neurodevelopmental patterns, increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood. In response to RFA-AA-21-007, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for the next 5 years a diverse community sample of mostly no-to-low male and female drinkers at baseline that NCANDA recruited when age 12-21 years and has tracked over the last 8 years (N=831; 93% retention rate) across 5 sites. Monitoring has involved annually-acquired multimodal neuroimaging (MRI, DTI, resting state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer and our mobile app. These measures will now be complemented with new advanced neuroimaging and sleep and physical activity tracking. This cohort sequential design uniquely positions NCANDA-A to quantify transient or enduring alcohol-related disturbances in specific adolescent and early adult neural system growth trajectories and functional concomitants. NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, NCANDA-A will investigate the impact of excessive alcohol drinking during adolescence and emerging adulthood on subsequent developmental trajectories of cognitive performance, brain structure and function, and psychopathology. Aim 2 analyses will identify neurodevelopment patterns describing the extent to which alcohol's effects on brain structure and function resolve or persist during desistance after binge drinking. Aim 3 will deploy data-driven analysis to identify adolescent biological, environmental, and behavioral factors (e.g., age of drinking onset) that forecast excessive drinking in individuals during early adulthood. In Aim 4, NCANDA-A will quantify the impact of the COVID pandemic on life stress and social, emotional, and economic wellbeing and their relations with alcohol use patterns. In Aim 5, the SRI and Pittsburgh sites will identify interactions among patterns of alcohol use, sleep, and cardiac function. In Aim 6, the UCSD, Duke and OHSU sites will determine the extent to which short-term (i.e., 4 weeks) alcohol use discontinuation results in acute improvement in cognition, affect, sleep and resting heart rate, and reversal of the adverse structural and functional brain effects of frequent binge alcohol use. For each aim, sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors will be tested. With the longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel information to the public on the enduring and transient effects of adolescent drinking on adult functioning by discovering elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.