National Consortium on Alcohol and Neurodevelopment in Adolescence: OHSU

项目摘要 众所周知，在青春期开始过量饮酒会扰乱典型的神经发育模式， 增加酒精使用障碍（AUD）的风险，并加速成年期的退化过程。 作为对RFA-AA-21-007的回应，本申请提出了国家联盟的研究项目地点 酒精与青少年-成年期神经发育（NCANDA-A）， NCANDA招募的基线时大多数为无至低饮酒男性和女性的多样化社区样本 年龄为12-21岁，在过去8年中在5个研究中心进行了跟踪（N=831; 93%留存率）。 监测涉及每年获得的多模态神经成像（MRI，DTI，静息状态fMRI，任务fMRI）， 认知、临床、行为和生物数据，亲自或通过计算机和我们的移动的远程收集 附录这些措施现在将补充新的先进的神经成像和睡眠和身体 活动追踪该队列顺序设计独特地定位了NCANDA-A，以量化短暂或持久的 特定青少年和早期成人神经系统生长轨迹中的酒精相关障碍， 功能性伴随物。 NCANDA-A提出了四个联盟范围的具体目标和两个专业项目目标。目标1：NCANDA-A 将调查青春期和成年期过度饮酒对 认知表现、大脑结构和功能的后续发展轨迹，以及 精神病理学目标2分析将确定神经发育模式，描述在何种程度上， 酒精对大脑结构和功能的影响在酗酒后停止饮酒期间消退或持续。目标3 将部署数据驱动的分析，以确定青少年的生物，环境和行为因素（例如，年龄 饮酒开始），预测在成年早期的个人过度饮酒。在目标4中， 将量化COVID大流行对生活压力以及社会、情感和经济福祉的影响， 与酒精使用模式的关系在目标5中，SRI和匹兹堡站点将确定 饮酒模式睡眠和心脏功能在目标6中，UCSD、杜克和OHSU站点将确定 短期（即，4周）酒精使用停止导致急性改善， 认知、情感、睡眠和静息心率，以及逆转大脑结构和功能的不良影响 频繁酗酒对于每一个目标，性别差异的发展，酒精使用模式和历史， 将测试饮酒对大脑的影响以及性别差异的心理社会因素。 随着在更新期间收集到成年早期的纵向数据，NCANDA-A将提供新的 向公众提供关于青少年饮酒对成年人功能的持久和短暂影响的信息， 发现将这些动态过程联系起来的要素和机制，并确定可改变的风险因素。

PROJECT SUMMARY Initiating excessive alcohol drinking during adolescence is known to disturb typical neurodevelopmental patterns, increase the risk of developing alcohol use disorder (AUD), and accelerate involutional processes in adulthood. In response to RFA-AA-21-007, this application proposes a Research Project Site of the National Consortium on Alcohol and Neurodevelopment in Adolescence - Adulthood (NCANDA-A) to follow for the next 5 years a diverse community sample of mostly no-to-low male and female drinkers at baseline that NCANDA recruited when age 12-21 years and has tracked over the last 8 years (N=831; 93% retention rate) across 5 sites. Monitoring has involved annually-acquired multimodal neuroimaging (MRI, DTI, resting state fMRI, task fMRI), cognitive, clinical, behavioral, and biological data, collected in person or remotely by computer and our mobile app. These measures will now be complemented with new advanced neuroimaging and sleep and physical activity tracking. This cohort sequential design uniquely positions NCANDA-A to quantify transient or enduring alcohol-related disturbances in specific adolescent and early adult neural system growth trajectories and functional concomitants. NCANDA-A proposes four consortium-wide specific aims and two specialty project aims. In Aim 1, NCANDA-A will investigate the impact of excessive alcohol drinking during adolescence and emerging adulthood on subsequent developmental trajectories of cognitive performance, brain structure and function, and psychopathology. Aim 2 analyses will identify neurodevelopment patterns describing the extent to which alcohol's effects on brain structure and function resolve or persist during desistance after binge drinking. Aim 3 will deploy data-driven analysis to identify adolescent biological, environmental, and behavioral factors (e.g., age of drinking onset) that forecast excessive drinking in individuals during early adulthood. In Aim 4, NCANDA-A will quantify the impact of the COVID pandemic on life stress and social, emotional, and economic wellbeing and their relations with alcohol use patterns. In Aim 5, the SRI and Pittsburgh sites will identify interactions among patterns of alcohol use, sleep, and cardiac function. In Aim 6, the UCSD, Duke and OHSU sites will determine the extent to which short-term (i.e., 4 weeks) alcohol use discontinuation results in acute improvement in cognition, affect, sleep and resting heart rate, and reversal of the adverse structural and functional brain effects of frequent binge alcohol use. For each aim, sex differences in development, alcohol use patterns and history, impact of alcohol use on the brain, and sex-differentiating psychosocial factors will be tested. With the longitudinal data collected into early adulthood during this renewal, NCANDA-A will provide novel information to the public on the enduring and transient effects of adolescent drinking on adult functioning by discovering elements and mechanisms linking these dynamic processes and identifying modifiable risk factors.