Training In Orthopaedic Team Science

 描述(申请人提供)：基因组学、细胞生物学和生物医学工程技术方面的新知识的爆炸性增长已经成熟，可以转化为新的骨科应用，以改善肌肉骨骼疾病患者的诊断和管理。骨科研究项目利用这一机会的速度一直很慢，因为这一学科固有的结构性障碍，使骨科外科医生和基础科学家在追求转化性研究项目方面越来越疏远。在这项申请中，我们提出了一种在学术环境中培训肌肉骨骼科学家的新范式，它模仿了制药公司使用的成熟的团队科学方法。整形外科团队科学培训(TTS)计划将赞助由骨科住院医师、博士后研究员、医学生和教职导师组成的发现团队追求限定良好的转化性研究项目。学员将完成一门核心课程，旨在提供肌肉骨骼病理生物学和临床研究执行基础的共同基础。研究和教学阶段的学习经验将由受训人员同时进行，以确保基础和临床团队成员之间的持续互动。充实计划将促进实习生和教职员工之间的互动，并提供有价值的职业发展培训。TTS指导委员会将监督项目和团队选择过程，并使用评估短期和长期措施的工具评估该计划的绩效。内部监督委员会将对该计划进行独立、持续的评估，并将协调来自受训人员、培训计划教职员工和外部咨询委员会的反馈。TOTS计划的成功实施预计将培养出肌肉骨骼科学家，他们将进入劳动力大军，拥有必要的翻译研究和领导力培训经验，以便在长凳和床边之间有效地转移发现。

 DESCRIPTION (provided by applicant): The explosion of new knowledge in genomics, cell biology and biomedical engineering technology is ripe for translation into new orthopaedic applications for improving the diagnosis and management of patients with musculoskeletal disorders. Orthopaedic research programs have been slow to capitalize on this opportunity because of inherent structural impediments in this discipline, which have increasingly distanced orthopaedic surgeons and basic scientists in the pursuit of translational research projects. In thi application, we propose a new paradigm for training musculoskeletal scientists in an academic setting, which is modeled after the proven, team science approach used by pharmaceutical companies. The Training in Orthopaedic Team Science (TOTS) program will sponsor the pursuit of well circumscribed, translational research projects by discovery teams composed of orthopaedic residents, post-doctoral Ph.D. fellows, medical students and faculty preceptors. Trainees will complete a Core Curriculum designed to provide a common grounding in musculoskeletal pathobiology and fundamentals in clinical research execution. Both research and didactic phases of the learning experience will occur concurrently by the trainees to ensure constant interaction between basic and clinical team members. An Enrichment Program will catalyze interactions between trainees and faculty and provide valuable career development training. The TOTS Steering Committee will oversee the project and team selection process, and evaluate the program's performance using tools for assessing short and long-term measures. An Internal Oversight Committee will provide independent, ongoing evaluation of the program and will coordinate feedback from trainees, training program faculty, and an External Advisory Committee. Successful implementation of the TOTS program is expected to produce musculoskeletal scientists who will enter the workforce with the requisite experience in translational research and leadership training to move discoveries effectively between the bench and bedside.