Histology

科赫研究所的成员使用脊椎动物模式生物作为研究已知或假定的 癌症基因的发展和致瘤性;研究肿瘤发生，发展的机制 和转移;评估基质和免疫反应在肿瘤发生中的作用;并评估疗效。 药物、纳米材料和设备在治疗和诊断方面的应用。因此，必须 中心成员能够正确诊断发育和肿瘤表型，评估潜在的 分子事件，并准确和定量地评估药物或疫苗输送和治疗反应。 科赫研究所组织学核心是一个共享资源，提供最先进的组织学服务， 支持这些研究。这包括在组织切片、载玻片制备和组织培养方面的协助和/或培训。 分析，并获得国际公认的兽医病理学家，博士的咨询服务。 Roderick Bronson用于诊断肿瘤和发育表型。在本报告所述期间， 这一核心得到了扩大和加强。这包括搬进一个更大的、定制设计的空间 在新的科赫研究所大楼，增加了工作人员和新仪器的收购，包括 增加了自动免疫组织化学和特殊染色功能。值得注意的是，在同一时期， 中心成员对组织学核心的使用从53%增加到67%，包括来自 四个方案。因此，这种共享资源对于科赫研究所使命的成功至关重要。在 在即将到来的时期，组织学核心将继续提供广泛的最先进的组织学服务 支持中心成员的研究计划。尽管服务业大幅扩张， 由于运行该核心的成本增加，因此CCSG第44年的预算要求基本不变 作为第39年的要求和建议预算。

Koch Institute Members use vertebrate model organisms as a key tool to study the role of known or putative cancer genes in development and tumorigenicity; investigate the mechanisms of tumor initiation, progression and metastasis; evaluate the role of stroma and immune responses in tumorigenesis; and assess the efficacy of drugs, nanomaterials and devices in therapeutic and diagnostic applications. Thus, it is essential that Center Members are able to correctly diagnose developmental and tumor phenotypes, evaluate the underlying molecular events, and accurately and quantitatively assess drug or vaccine delivery and therapeutic response. The Koch Institute Histology Core is a Shared Resource that provides state-of-the-art histological services to support these studies. This includes assistance and/or training in tissue sectioning, slide preparation and analysis, and access to the consultative services of an internationally recognized Veterinary Pathologist, Dr. Roderick Bronson for diagnosis of tumor and developmental phenotypes. In the current period, the capabilities of this Core have been expanded and enhanced. This includes moving into a larger, custom-designed space in the new Koch Institute building, an increase in the staff and the acquisition of new instrumentation including the addition of automated immunohistochemistry and special staining capabilities. Notably, in the same period, usage of the Histology Core by Center Members increased from 53% to 67%, and included investigators from all four Programs. Thus, this Shared Resource is essential to the success of the Koch Institute mission. In the upcoming period, the Histology Core will continue to offer a wide range of state-of-the-art histological services to support the research programs of Center Members. In spite of the significant expansion of services, and the resulting increased costs of running this Core, the requested CCSG budget for Year 44 is essentially the same as the requested and recommended budget in Year 39.