Research Training in Pediatric Urology/Boston Children's Hospital

描述（由申请人提供）：这是波士顿儿童医院儿科泌尿学研究培训的国家研究服务奖（NRSA）机构培训补助金（T32）的竞争性更新申请。在过去的10年里，这一资助机制支持了我们儿科泌尿学奖学金项目的研究部分。波士顿儿童医院的儿科泌尿科奖学金是世界上最古老和最受推崇的此类项目之一。BCH的泌尿外科是世界领先的儿科泌尿外科和泌尿生殖系统重建中心之一，拥有国内最大的致力于泌尿基础研究的研究项目之一。该部门是BCH泌尿系统疾病研究中心的所在地，该中心是由NIDDK提供的P50赠款资助的乔治奥布莱恩泌尿系统研究中心。该项目的总体目标是：(1)增强学员对细胞生理学基本机制、疾病分子基础的理解，并将其转化为临床泌尿外科；(2)教授与基础科学和临床研究相关的最先进的、假设驱动的研究方法；(3)提供足够的时间和指导，使其在基础、转化或临床研究方面获得成熟的博士后经验，与实习生未来的临床生涯和学术领导角色相关。在最近的资助周期中，完成泌尿外科住院医师培训的博士后医学博士学员在3年奖学金的2年中不间断地在两种环境中进行研究：(i)基于实验室的泌尿生殖道发育、生理学和病理生理学研究，或（ii）与哈佛大学公共卫生学院的教师合作进行临床结果和卫生服务研究。受训者还将接受批判性思维和拨款写作、生物统计学和责任方面的教学培训

DESCRIPTION (provided by applicant): This is a competitive renewal application for a National Research Service Award (NRSA) Institutional Training grant (T32) for research training in pediatric urology at Boston Children's Hospital. For the past 10 years, this funding mechanism has supported the research component of our pediatric urology fellowship program. The pediatric urology fellowship at Boston Children's Hospital is the oldest and one of the most highly regarded such programs in the world. The Urology Department at BCH is one of the world's leading centers for pediatric urology and genitourinary reconstruction and has one of the largest research programs dedicated to basic urology research in the country. The department is home to the BCH Urological Diseases Research Center, a George O'Brien Urology Research Center funded by a P50 grant from the NIDDK. The overall goals of the program are: (1) to enhance the trainees' understanding of basic mechanisms of cell physiology, the molecular basis of disease, and their translation to clinical urology; (2) to teach state- of-the-art, hypothesis-driven research methodology relevant to both basic science and clinical research; and (3) to provide sufficient time and guidance for a mature postdoctoral experience in basic, translational or clinical studies relevant to the trainees' future clinical careers and academic leadership roles. In the most recent funding cycle, postdoctoral MD trainees who have completed urology residency have conducted research in one of two settings during 2 uninterrupted years of the 3-year fellowship: (i) laboratory-based studies of urogenital tract development, physiology and pathophysiology or (ii) clinical outcomes and health services research in conjunction with faculty at the Harvard School of Public Health. Trainees will also undergo didactic training in critical thinking and grant writing, biostatistics and the responsible conduct of research. Four postdoctoral positions are requested per year for 2 years of research training. Twenty-seven mentors comprising basic science and clinical faculty, from 8 programs will support the training program. The fellowship represents a unique combination of outstanding clinical and basic research training within one of the world's leading centers for academic medicine and biomedical science. It is designed to enable our graduates to establish their own competitive programs of scholarship and research during their careers as academic pediatric urologists. These clinician-scientists can then contribute to understanding the genitourinary system in fundamental terms and to translating basic research findings into clinical applications. The T32 Pediatric Urology Research Training mechanism is the major source of support for the fellows during the 2-year research component of their fellowship.