A memory of errors in motor adaptation

运动适应错误的记忆

• 批准号: 9003804
• 负责人: David James Herzfeld
• 金额: $ 1.94万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-01-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9003804
• 关键词: Accounting; Affect; Behavioral; Brain; Clinic; Clinical; Computer Simulation; Controlled Study; Data; Dependence; Disease; Elements; Equation; Exhibits; Financial compensation; Foundations; Goals; Human; Individual; Learning; Link; Literature; Memory; Methods; Modeling; Monitor; Motor; Motor output; Movement; Nervous System Trauma; Nervous system structure; Neurosciences; Outcome; Process; Recipe; Recording of previous events; Rehabilitation therapy; Research; Savings; Sensory; Speed; Techniques; Testing; Time; Training; Trauma; base; behavioral study; experience; insight; motor control; motor learning; motor recovery; motor rehabilitation; public health relevance; research study; theories

DESCRIPTION (provided by applicant): When we practice a motor task, we can do it better the next time we revisit it. How is this accomplished? The basic assumption in neuroscience has been that this phenomenon, called 'savings', occurs because when we revisit the task, the brain recalls the motor commands that it had previously learned. In this view, motor memory is a memory of motor commands. In contrast to these views, here we propose that motor memory includes a memory of errors, i.e., when we are better at a task, it is often not because we remember the motor commands that we learned before, but because we remember the errors that we have seen before. We propose that this counter-intuitive and previously unknown form of memory, a memory of errors, can account for a very large body of puzzling and unexplained experimental data in the motor learning literature. In this proposal, we begin with a puzzle: in a motor learning task, humans are able to modulate how much they learn from a given error. In some conditions, they learn a large amount, but in other conditions they learn only a small amount. That is, the brain selects how much it is willing to learn from error. To understand the rules that govern control of error-sensitivity, we manipulate the history of errors that subjects experience, and find that positive autocorrelations of errors up-regulate sensitivity, whereas negative autocorrelations down-regulate sensitivity, but only at the specific errors that were actually experienced. That is, experience of an error produces a change in motor commands via errors-sensitivity, which in turn depends on the history of past errors, allowing the brain to respond differently to an error that was experienced before. We formulate this idea with a set of mathematical equations that extend the current framework of learning and show that this new set of equations, representing memory of errors, seamlessly connects a large body of puzzling data. Building on these preliminary results, we propose two groups of experiments to test the foundations of this new idea. The first set of experiments test the prediction that correlations of past errors will modulate error-sensitivity, and that this modulation will be local to the specific errors that were experience. The second set of experiments test the prediction that modulation of error-sensitivity via memory of errors is the basis for the phenomenon of saving. From a clinical standpoint, understanding error-sensitivity is important as it directly affects motor rehabilitation for neuro-trauma or disease. Our theory provides a recipe to modulate error-sensitivity, which should produce faster adaptation, potentially affecting the duration of rehabilitation. In addition, understanding the relationship between error sensitivity and savings may provide useful clues regarding how to effectively apply rehabilitation techniques to promote faster re-learning outside the clinic.

描述(由申请者提供)：当我们练习一项运动任务时，我们下次再去看它时可以做得更好。这是如何实现的？神经科学中的基本假设是，这种现象之所以会发生，是因为当我们重新审视这项任务时，大脑会回想起它以前学过的运动指令。在这个观点中，运动记忆是对运动命令的记忆。与这些观点相反，我们在这里提出，运动记忆包括对错误的记忆，即当我们在一项任务中做得更好时，通常不是因为我们记住了我们以前学到的运动命令，而是因为我们记住了我们以前见过的错误。我们认为，这种反直觉和以前未知的记忆形式，一种错误的记忆，可以解释运动学习文献中大量令人费解和无法解释的实验数据。在这个提案中，我们从一个谜题开始：在一个 在运动学习任务中，人类能够调节他们从给定错误中学到了多少。在某些情况下，他们学到了很多，但在其他情况下，他们只学到了很少的量。也就是说，大脑选择它愿意从错误中学习多少。为了理解控制错误敏感性的规则，我们操纵了受试者经历过的错误的历史，发现错误的正相关提高了敏感性，而负相关降低了敏感性，但仅限于实际经历的特定错误。也就是说，对错误的体验通过错误敏感度产生运动命令的变化，而错误敏感度又取决于过去错误的历史，从而允许大脑对以前经历的错误做出不同的反应。我们用一组数学方程式来阐述这个想法，这些方程式扩展了目前的学习框架，并表明这组代表错误记忆的新方程式无缝地连接了大量令人困惑的数据。在这些初步结果的基础上，我们提出了两组实验来测试这一新想法的基础。第一组实验测试了这种相关性的预测 过去的错误将调制错误敏感度，并且这种调制将是特定的局部的 有经验的错误。第二组实验验证了错误记忆对错误敏感性的调制是储存现象的基础的预测。从临床的角度来看，理解错误敏感性很重要，因为它直接影响神经创伤或疾病的运动康复。我们的理论提供了一个调整错误敏感性的配方，这应该会产生更快的适应，潜在地影响康复的持续时间。此外，了解错误敏感性和节省之间的关系可能会为如何有效地应用康复技术来促进在诊所外更快地重新学习提供有用的线索。