Real-time pediatric cardiovascular MRI without breath holding, ECG monitoring or respiratory navigation

实时儿科心血管 MRI，无需屏气、心电图监测或呼吸导航

• 批准号: 9406546
• 负责人: Yu Yulee Li
• 金额: $ 17.24万
• 依托单位: ST. FRANCIS HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9406546
• 关键词: Real; time; pediatric; cardiovascular; MRI

 DESCRIPTION (provided by applicant) Magnetic resonance imaging (MRI) offers an ideal approach to imaging congenital and acquired cardiovascular diseases in pediatric patients because it is non-invasive, radiation-free and information-rich. However, the general applicability of pediatric cardiovascular MRI is constrained by two challenges. First, currently available techniques cannot collect data faster than cardiac and respiratory motion. Second, children are uncooperative, unstable and vulnerable, making it difficult to employ conventional motion-control techniques that require patient cooperation, e.g., k-space segmentation with breath holding. To overcome these challenges, the proposed project will translate a novel high-speed MRI framework into a data acquisition paradigm that can image the moving heart in real-time. This framework, which is called "correlation imaging", can overcome the speed limit of available MRI techniques using linear data acquisition and image reconstruction strategies, providing a clinically translatable approach to improving the applicability of pediatric cardiovascular MRI. In this proposed 5-year project, we will translate correlation imaging into a real-time imaging tool that can collect data faster than cardiac and respiratory motion on clinical MRI scanners. We will establish a new real- time data acquisition paradigm for pediatric cardiovascular MRI examination without breath holding, electrocardiogram (ECG) monitoring or respiratory navigation in our institution. In addition, we will develop an innovative Fourier analysis approach that can assess cardiovascular function by evaluating blood circulation periodicity from real-time images collected over a series of sequential cardiac cycles. We expect that the proposed research will transform pediatric cardiovascular MRI by reducing motion complications and thus improving disease prognosis and diagnosis. The proposed project will be carried out by a research team of experts from the fields of engineering, physics and cardiology. We will bridge the expertise of scientific, clinical and industrial researchers in order to translate our new high-speed data acquisition technique into pediatric cardiovascular MRI. Since imaging speed is a critical barrier to many areas of clinical MRI, however, our research promises an even more widespread impact on the field of clinical imaging.

 描述（由申请人提供） 磁共振成像（MRI）提供了一个理想的方法来成像先天性和后天性心血管疾病的儿科患者，因为它是非侵入性，无辐射和信息丰富。然而，儿科心血管MRI的普遍适用性受到两个挑战的限制。首先，目前可用的技术不能比心脏和呼吸运动更快地收集数据。其次，儿童不合作，不稳定和脆弱，使得难以采用需要患者合作的传统运动控制技术，例如，屏气的k空间分割。 为了克服这些挑战，该项目将把一种新型的高速MRI框架转化为一种数据采集模式，可以实时对运动的心脏进行成像。这个框架，这是所谓的“相关成像”，可以克服现有的MRI技术的速度限制，使用线性数据采集和图像重建策略，提供了一个临床上可翻译的方法，以提高儿科心血管MRI的适用性。 在这个拟议的5年项目中，我们将把相关成像转化为一种实时成像工具，它可以比临床MRI扫描仪上的心脏和呼吸运动更快地收集数据。我们将建立一个新的真实的实时数据采集范例，用于儿科心血管MRI检查，无需屏气，心电图（ECG）监测或呼吸导航。此外，我们将开发一种创新的傅立叶分析方法，该方法可以通过从一系列连续心动周期收集的实时图像中评估血液循环周期性来评估心血管功能。我们希望这项研究将通过减少运动并发症来改变儿科心血管MRI，从而改善疾病预后和诊断。 拟议的项目将由工程、物理和心脏病学领域的专家组成的研究小组进行。我们将在科学、临床和工业研究人员的专业知识之间架起桥梁，将我们新的高速数据采集技术转化为儿科心血管MRI。然而，由于成像速度是临床MRI许多领域的关键障碍，因此我们的研究有望对临床成像领域产生更广泛的影响。