Diet and Exercise Trial to Improve Insulin Resistance, Increase Cerebral Blood Flow, Alter Metabolomic Biomarkers, and Decrease Alzheimer's Disease Risk
Diet and Exercise Trial to Improve Insulin Resistance, Increase Cerebral Blood Flow, Alter Metabolomic Biomarkers, and Decrease Alzheimer's Disease Risk
批准号:
9166391
负责人:
Barbara Brigitta Bendlin
金额:
$22.95万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-30 至 2018-04-30
关键词:
AccountingAcuteAdherenceAdultAlzheimer&aposs DiseaseAlzheimer&aposs disease riskBehavior TherapyBiochemical ProcessBiological MarkersBlood GlucoseBlood flowBlood specimenBody Weight decreasedBrainBranched-Chain Amino AcidsCarbohydratesCardiovascular DiseasesCerebrovascular CirculationChronicCitric Acid CycleCognitionComplementCouplingDataDementiaDevelopmentDiabetes MellitusDietDietary CarbohydratesDiseaseEarly treatmentExerciseFastingFatty AcidsGene ProteinsGlucoseGoalsHealthHourHumanHyperglycemiaImpaired cognitionImpaired fasting glycaemiaIndividualInformal Social ControlInsulin ResistanceInterventionKnowledgeLife StyleLinkMagnetic Resonance ImagingMeasurementMeasuresMemoryMetabolicMetabolic PathwayMetabolic syndromeMitochondriaModificationMonitorNeutral Amino AcidsNutritionalObservational StudyParticipantPathway interactionsPrevalencePsyche structurePublic HealthRecording of previous eventsRecruitment ActivityReportingResearchRiskRisk FactorsSelf EfficacyTestingTherapeuticThinkingUrineVO2maxWisconsinacylcarnitinebaseblood glucose regulationbrain healthcardiorespiratory fitnesscognitive functiondesigndiabeticdiet and exercisedietary restrictiondisorder riskexercise programfatty acid oxidationfollow-upglucose monitorglycemic controlgut microbiomeimprovedimproved functioninginsulin sensitivitymetabolic profilemetabolomemetabolomicsmiddle ageoxidationpersonalized careprimary outcomeresponse
中文摘要
项目总结
英文摘要
Project Summary
Metabolic syndrome (MetS) is associated with the development of diabetes and cardiovascular
disease; however it is also linked with cognitive decline and dementia. We have shown that MetS is
associated with lower cerebral blood flow (CBF) and memory function in late middle-aged adults at increased
risk for developing Alzheimer’s disease (AD). Insulin resistance (IR) is at the core of MetS, and a hallmark
feature of IR is higher fasting blood glucose (FBG) as well as post prandial hyperglycemia.
While we and others have demonstrated links between IR and CBF as well as cognition from an
observational perspective, no studies have investigated CBF and cognition after an intervention involving
exercise and a carbohydrate restricted diet (CRD) designed to improve or normalize IR and glucose
homeostasis. We propose to determine the effect of improving or normalizing glucose homeostasis on CBF
and cognition, through diet and exercise, in individuals with IR and at risk for the development of AD.
While exercise and a CRD have been shown to improve IR and glycemic control, we have only limited
knowledge of the mechanisms behind these improvements. Nutritional metabolomics, the global measurement
and interpretation of metabolic profiles, assesses the interaction of diet with the endogenous gene-protein
cascade and the gut microbiome. Additionally, exercise has been shown to have an impact on the human
metabolome. Finally, numerous metabolites have been specifically linked to IR and impaired fasting glucose
(IFG). We propose to use metabolomics to measure changes in metabolites as individuals normalize or
improve IR and glucose homeostasis.
Should this exploratory study reveal increased brain blood flow and improved memory in response to
diet and exercise, then early treatment of these individuals at risk might offer new avenues for disease-course
modification. Strategies towards early and effective risk factor management could be of value in reducing the
risk of metabolic as well as cognitive decline. In addition, should this study reveal changes in metabolic
abnormalities consistent with early indications of diabetes, metabolomics could be an effective approach to
complement disease risk analysis in our goal toward precision care.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
ß-hydroxybutyrate inhibition of pathology in Alzheimer's disease
-
批准号:10739679
-
项目类别:
-
资助金额:$75.24万
-
财政年份:2023
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)
-
批准号:10803585
-
项目类别:
-
资助金额:$349.4万
-
财政年份:2021
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
Administrative Supplement to Establish National Exposome Alzheimer's Disease and Related Dementias (ADRD) Infrastructure (Expo-AD)
-
批准号:10658250
-
项目类别:
-
资助金额:$345.15万
-
财政年份:2021
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
Gut barrier function in Alzheimer’s disease
-
批准号:10614373
-
项目类别:
-
资助金额:$73.99万
-
财政年份:2021
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)
-
批准号:10361428
-
项目类别:
-
资助金额:$630.81万
-
财政年份:2021
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
Gut barrier function in Alzheimer’s disease
-
批准号:10350685
-
项目类别:
-
资助金额:$74.82万
-
财政年份:2021
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)
-
批准号:10580795
-
项目类别:
-
资助金额:$635.49万
-
财政年份:2021
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
Research Education Component
-
批准号:10385840
-
项目类别:
-
资助金额:$22.26万
-
财政年份:2019
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
Research Education Component
-
批准号:10601075
-
项目类别:
-
资助金额:$21.5万
-
财政年份:2019
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
SV2A PET imaging in Alzheimer's Disease
-
批准号:9919489
-
项目类别:
-
资助金额:$113.34万
-
财政年份:2018
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
SV2A PET imaging in Alzheimer's Disease
-
批准号:10403978
-
项目类别:
-
资助金额:$112.92万
-
财政年份:2018
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
SV2A PET imaging in Alzheimer's Disease
-
批准号:10177835
-
项目类别:
-
资助金额:$113.14万
-
财政年份:2018
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
White matter degeneration: biomarkers in preclinical Alzheimer's Disease
-
批准号:10606478
-
项目类别:
-
资助金额:$75.62万
-
财政年份:2012
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
White matter degeneration: biomarkers in preclinical Alzheimer's Disease
-
批准号:10390318
-
项目类别:
-
资助金额:$76.01万
-
财政年份:2012
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
White matter degeneration: biomarkers in preclinical Alzheimer's Disease
-
批准号:8461579
-
项目类别:
-
资助金额:$29.16万
-
财政年份:2012
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
White matter degeneration: biomarkers in preclinical Alzheimer's Disease
-
批准号:8667387
-
项目类别:
-
资助金额:$30.52万
-
财政年份:2012
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
White matter degeneration: biomarkers in preclinical Alzheimer's Disease
-
批准号:8297257
-
项目类别:
-
资助金额:$30.85万
-
财政年份:2012
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
Midlife Insulin Resistance and Obesity: Risk Factors for AD-Related Brain Change
-
批准号:8829118
-
项目类别:
-
资助金额:$12.94万
-
财政年份:--
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
Midlife Insulin Resistance and Obesity: Risk Factors for AD-Related Brain Change
-
批准号:8677363
-
项目类别:
-
资助金额:$13.34万
-
财政年份:--
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
Midlife Insulin Resistance and Obesity: Risk Factors for AD-Related Brain Change
-
批准号:9261450
-
项目类别:
-
资助金额:$13.34万
-
财政年份:--
-
负责人:Barbara Brigitta Bendlin
-
依托单位:
海外基金