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英文摘要
Project Summary/Abstract The overall goal of this research program is to understand how parallel retinofugal pathways are established during development. This proposal focuses on the question of how retinal ganglion cell (RGC) axons select their correct targets and target layers in the brain during development. RGC axon-target and axon-layer matching are both critical aspects of visual circuit organization and yet, very little is known about how they develop in mammals. We propose to study the development of these connections in transgenic mice where specific RGC subtypes express fluorescent proteins and in which specific genes are absent or misexpressed in the retinofugal pathway. The specific aims of this proposal are to 1) characterize the cellular events that enable RGCs carrying different qualities of visual information to recognize their appropriate targets in the brain, 2) test the hypothesis that the adhesion molecule cadherin-6 controls RGC axon-target matching 3) test the hypothesis that lamina specific targeting of axons from direction selective RGCs to the superior colliculus is mediated by the adhesion molecule cadherin-7. Results from these experiments should lead to new understanding of how mammalian visual circuits are established and inform strategies for maintaining and replenishing visual circuits in response to injury or disease.
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Promoting optic nerve and retinofugal pathway regeneration
  • 批准号:
    9338034
  • 项目类别:
  • 资助金额:
    $39.38万
  • 财政年份:
    2015
  • 负责人:
    Andrew D Huberman
  • 依托单位:
Development of retinofugal parallel pathways
Development of retinofugal parallel pathways
Development of retinofugal parallel pathways
  • 批准号:
    9338070
  • 项目类别:
  • 资助金额:
    $8.71万
  • 财政年份:
    2012
  • 负责人:
    Andrew D Huberman
  • 依托单位:
国内基金
海外基金
Sitagliptin通过microbiota-gut-brain轴在2型糖尿病致阿尔茨海默样变中的脑保护作用机制
  • 批准号:
    81801389
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    21.0万元
  • 批准年份:
    2018
  • 负责人:
    田茗源
  • 依托单位:
平扫描数据导引的超低剂量Brain-PCT成像新方法研究
  • 批准号:
    81101046
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    23.0万元
  • 批准年份:
    2011
  • 负责人:
    黄静
  • 依托单位: