Assessment of joint effects of pesticides and air pollution in pediatric asthma
农药和空气污染对小儿哮喘的联合影响评估
基本信息
- 批准号:9057040
- 负责人:
- 金额:$ 15.37万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-04-20 至 2018-03-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressAdolescentAdoptionAffectAgeAgricultureAir PollutantsAir PollutionApplications GrantsAsthmaBayesian AnalysisBayesian MethodBiological MarkersBiometryCaliforniaCarbamatesChargeChildChild health careChildhoodChildhood AsthmaChronicCohort StudiesCollectionColoradoCommunitiesComplexDataDatabasesDemographic FactorsDevelopmentDiseaseDustEnrollmentEnvironmentEnvironmental EpidemiologyEnvironmental ExposureEnvironmental HazardsEnvironmental HealthEnvironmental PollutantsEnvironmental Risk FactorEpidemiologic StudiesEpidemiologistEpidemiologyEtiologyEvaluationExposure toForced expiratory volume functionFutureGoalsHealthHealth SciencesIncidenceIntegration Host FactorsInvestigationJointsK-Series Research Career ProgramsLaboratoriesLeadLifeLinear ModelsMeasuresMethodsMissionModelingMorbidity - disease rateNational Institute of Environmental Health SciencesNatureOrganophosphatesPatternPerformancePesticidesPlayPoisonPoliciesPopulationPositioning AttributePulmonary Function Test/Forced Expiratory Volume 1RaceRadiologic HealthRecording of previous eventsReportingResearchRespiratory physiologyRiskRisk FactorsRoleSample SizeSamplingStatistical MethodsStatistical ModelsToxicologyTrainingUniversitiesWorkambient air pollutionanthropogenesisasthmaticbasecareercohortcomparative efficacydesigndevelopment policyearly childhoodearly life exposureexperienceland uselung developmentnovelnovel strategiespesticide exposurepollutantpopulation basedprofessorprogramspulmonary functionrespiratoryrespiratory healthsample collectionsexsimulationsocialsocioeconomicsstressortenure trackurinary
项目摘要
DESCRIPTION (provided by applicant): The research objective of this K22 Career Development Award (CDA) is to ascertain if agricultural pesticide exposure confounds or modifies the relation between ambient air pollution exposure and pulmonary function in children with asthma. The central hypothesis is that early-life exposure to agricultural pesticides in conjunction with exposure to high levels of ambient air pollution is associated significantly with decreased lung function. The respiratory effects of chronic exposure to agricultural pesticides in childhood remain unknown. As the State of California has required full reporting of agricultural pesticide use for over two decades, retrospective exposure assessment of community-level pesticide application can be conducted effectively for hypothesized critical windows for asthma etiology. In addition to pesticide exposure, the land use patterns and topography of the San Joaquin Valley, the state's major agricultural region, result in high levels of exposure to ambient
air pollution (AAP). The Fresno Asthmatic Children's Environment Study (FACES) offers a well-characterized longitudinal cohort to investigate the simultaneous effects of pesticides and AAP on changes in lung function and development of asthma. The research approach will consist of three Specific Aims. (Aim 1): Implementation of three pesticide exposure assessment strategies (geographic-based exposure, collection of dust samples, and collection of urinary biomarkers) to estimate associations with current lung function in the FACES cohort. We hypothesize that the relation between lung function and pesticides will vary by exposure assessment method and by class of pesticide. We anticipate that these short-term exposure measures can be used to calibrate the long-term pesticide exposures estimates. (Aim 2): Comparison of two Bayesian statistical methods to understand the relation between agricultural pesticide exposure and lung function. This aim will consist of statistical simulations that will be conducted with pesticide exposure estimates informed by Aim 1 and retrospective air pollution data based on residential histories from the FACES cohort (n = 315). The relation between lung function, environmental exposures and demographic covariates (sex and race) will be analyzed using two recently developed statistical methods, nonparametric Bayes shrinkage and profile regression. The objective of this aim is to understand the statistical model performance of these Bayesian approaches for research of complex environmental mixtures and demographic factors. (3). Assessment of the independent and joint effects of pesticide exposure in combination with ambient air pollution on lung function. We will estimate the effect of early childhood (ages 0 - 1)
exposure to community-level pesticide and ambient air pollutants on baseline lung function from the FACES cohort (n=315) in a model derived in Aim 2. We hypothesize that early childhood (0 - 1 year) exposure to three classes of agricultural pesticides will modify the relation between air
pollution and FEV1 measured at study enrollment (ages 6 - 11). The CDA Candidate is a tenure-track Assistant Professor of Epidemiology in the Department of Environmental and Radiological Health Sciences at Colorado State University (CSU) with training in environmental and social epidemiology. Her short-term career goal is to expand her current research in asthma epidemiology and develop a research program to address multi-pollutant exposure analyses in vulnerable communities, with specific focus on agricultural pesticide exposures and ambient air pollution. Her long-term career goal is to understand the dynamic interaction of environmental pollutants, biogenic exposures, and host factors on asthma incidence in children. This CDA will support her didactic and experiential training in toxicology and Bayesian statistics. Her statisticl training for this grant application is necessitated by the inferential limitations of conventional statistical methods (e.g. generalized linear models) for multi-pollutant analyses (i.e. regarding assessment of toxic compounds given application of mixtures or combinations of pesticides) and multi-domain analyses (i.e. ascertainment of the independent contribution of pesticides among combinations of correlated factors, both anthropogenic and biogenic in nature.) These statistical approaches must be informed by an understanding of compound interaction on a toxicological level. Her biostatistics training will include data simulation and Bayesian approaches for epidemiologic studies; toxicology training will include course work, field work in exposure assessment, and laboratory work in environmental and biomarker sample analysis. Her department has expertise in environmental epidemiology, exposure assessment and toxicology; the campus offers comprehensive training in applied statistical approaches and methods. These experiences will inform the conduct of this CDA, as well as future work transdisciplinary research environmental health. This CDA supports the mission of the NIEHS via investigation of the health effects of low-level chronic exposures.
描述(由申请人提供):本次K22职业发展奖(CDA)的研究目的是确定农药暴露是否混淆或修改环境空气污染暴露与哮喘儿童肺功能之间的关系。核心假设是,早期接触农业农药以及暴露于高水平的环境空气污染与肺功能下降显著相关。儿童时期长期接触农业农药对呼吸道的影响尚不清楚。由于加州20多年来一直要求全面报告农业农药使用情况,因此可以有效地对社区水平农药应用进行回顾性暴露评估,以推测哮喘病因的关键窗口。除了农药暴露外,该州主要农业区圣华金河谷的土地利用模式和地形也导致了高水平的环境农药暴露
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Sheryl Magzamen其他文献
Sheryl Magzamen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Sheryl Magzamen', 18)}}的其他基金
Antimicrobial Resistant Bacteria: Exposures and Health of Cattle Workers
耐药细菌:养牛工人的接触和健康
- 批准号:
10227645 - 财政年份:2020
- 资助金额:
$ 15.37万 - 项目类别:
Antimicrobial Resistant Bacteria: Exposures and Health of Cattle Workers
耐药细菌:养牛工人的接触和健康
- 批准号:
10030543 - 财政年份:2020
- 资助金额:
$ 15.37万 - 项目类别:
Antimicrobial Resistant Bacteria: Exposures and Health of Cattle Workers
耐药细菌:养牛工人的接触和健康
- 批准号:
10437480 - 财政年份:2020
- 资助金额:
$ 15.37万 - 项目类别:
Antimicrobial Resistant Bacteria: Exposures and Health of Cattle Workers
耐药细菌:养牛工人的接触和健康
- 批准号:
10783823 - 财政年份:2020
- 资助金额:
$ 15.37万 - 项目类别:
Evaluation of California's 2020 chlorpyrifos cancellation on health and exposure in agricultural communities
加州2020年取消毒死蜱对农业社区健康和暴露的影响评估
- 批准号:
10260580 - 财政年份:2020
- 资助金额:
$ 15.37万 - 项目类别:
Validation of the UPAS+: A filter-based air sampler coupled with a suite of real-time sensors
UPAS 的验证:基于过滤器的空气采样器与一套实时传感器相结合
- 批准号:
10312360 - 财政年份:2014
- 资助金额:
$ 15.37万 - 项目类别:
Design and Evaluation of Interventions to Improve Dairy Worker Respiratory Health
改善乳制品工人呼吸健康的干预措施的设计和评估
- 批准号:
8866787 - 财政年份:2014
- 资助金额:
$ 15.37万 - 项目类别:
相似海外基金
Enhancing Structural Competency in School-Based Health Centers to Address LGBTQ+ Adolescent Health Equity
增强校本健康中心的结构能力,以解决 LGBTQ 青少年健康公平问题
- 批准号:
10608426 - 财政年份:2023
- 资助金额:
$ 15.37万 - 项目类别:
Application and feasability of a brief digital screening tool to address parental and adolescent tobacco and electronic cigarette use in pediatric medical care - a pilot study
简短的数字筛查工具的应用和可行性,以解决儿科医疗中父母和青少年烟草和电子烟的使用问题 - 一项试点研究
- 批准号:
486580 - 财政年份:2022
- 资助金额:
$ 15.37万 - 项目类别:
Studentship Programs
Co-design of an intervention to address alcohol use among adolescent boys and young men in Tanzania
共同设计一项干预措施,解决坦桑尼亚青春期男孩和年轻男性的饮酒问题
- 批准号:
MR/V032380/1 - 财政年份:2022
- 资助金额:
$ 15.37万 - 项目类别:
Research Grant
Complex intervention to optimise adolescent BMI pre-conception to address the double burden of malnutrition: A RCT in rural and urban South Africa
优化青少年孕前体重指数以解决营养不良的双重负担的复杂干预措施:南非农村和城市的随机对照试验
- 批准号:
MR/V005790/1 - 财政年份:2021
- 资助金额:
$ 15.37万 - 项目类别:
Research Grant
Application of a brief digital screening tool to address parental and adolescent tobacco and electronic cigarette use in pediatric medical care
应用简短的数字筛查工具来解决儿科医疗中父母和青少年烟草和电子烟的使用问题
- 批准号:
455984 - 财政年份:2021
- 资助金额:
$ 15.37万 - 项目类别:
Operating Grants
Complex intervention to optimise adolescent BMI pre-conception to address the double burden of malnutrition: A RCT in rural and urban South Africa
优化青少年孕前体重指数以解决营养不良的双重负担的复杂干预措施:南非农村和城市的随机对照试验
- 批准号:
MR/V005790/2 - 财政年份:2021
- 资助金额:
$ 15.37万 - 项目类别:
Research Grant
Development of the Cannabis Actions and Practices (CAP): A Parent-Focused Intervention to Address Adolescent Marijuana Use
大麻行动和实践 (CAP) 的发展:以家长为中心的干预措施,解决青少年大麻使用问题
- 批准号:
10057761 - 财政年份:2020
- 资助金额:
$ 15.37万 - 项目类别:
Development of the Cannabis Actions and Practices (CAP): A Parent-Focused Intervention to Address Adolescent Marijuana Use
大麻行动和实践 (CAP) 的发展:以家长为中心的干预措施,解决青少年大麻使用问题
- 批准号:
10213683 - 财政年份:2020
- 资助金额:
$ 15.37万 - 项目类别:
Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
- 批准号:
9403567 - 财政年份:2017
- 资助金额:
$ 15.37万 - 项目类别:
Designing targeted interventions to address HIV vulnerabilities and improve clinical outcomes among conflict affected adolescent girls and young women under 25 in Northern Uganda
设计有针对性的干预措施,以解决乌干达北部受冲突影响的少女和 25 岁以下年轻妇女的艾滋病毒脆弱性并改善临床结果
- 批准号:
356145 - 财政年份:2016
- 资助金额:
$ 15.37万 - 项目类别:
Operating Grants