Mesoscopic Diffusion-based MRI Histology of Epileptic Human Hippocampi

基于介观扩散的 MRI 人类癫痫海马组织学

基本信息

  • 批准号:
    8890388
  • 负责人:
  • 金额:
    $ 21.47万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-03-01 至 2017-02-28
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Epilepsy is the fourth most common neurological disorder in the United States with an approximate cost of $17.6 billion per year. Anti-epileptic medication is effective in most cases, but is insufficient to control seizures in as many as 40% of patients. Patients with focal epilepsy that can be shown to arise from a specific brain region, by noninvasive testing (EEG, imaging studies) or invasive intracranial recordings, are candidates for surgical resection. The most common type of resective epilepsy surgery is anterior temporal lobectomy, which includes removal of the hippocampus. There is good evidence that there is an ictal focus, a region where the seizure originates (typically defining the target for surgical intervention), but the functional anatomy of the seizure also affects regions downstream and is modulated by the input to the ictal focus. Understanding the seizure network, rather than merely the ictal focus (where aberrant processing converges to produce uncontrolled activity), will be an important advance to improve our surgical interventions and care for the affected individuals. Nevertheless current approaches such as clinical MRI or EEG, as well as neuropathology are inadequate to resolve the seizure network. We therefore here propose to investigate the use of mesoscale MRI on surgically-resected epileptic hippocampi to uncover anatomical changes that constitute a seizure network. Specificially, we here aim to: 1) further develop diffusion-based MR histology to better distinguish cell layer and axonal connectivity, as well as 2) implementing a 3 dimensional reconstruction of histological sections to validate tractographic reconstructions. The overarching goal is to provide a method that can lead to a better description of the seizure network to improve our understanding of mTLE with a tangible benefit to patients undergoing a hippocampectomy by improving the differential diagnosis, as well as pre-surgical planning
 描述(由申请人提供):癫痫是美国第四常见的神经系统疾病,每年造成的损失约为176亿美元。抗癫痫药物在大多数情况下是有效的,但不足以控制多达40%的癫痫发作。 患者通过非侵入性测试(EEG,成像研究)或侵入性颅内记录显示局灶性癫痫起源于特定脑区的患者是手术切除的候选人。切除性癫痫手术最常见的类型是前颞叶切除术,其中包括切除海马。有很好的证据表明存在发作病灶,即癫痫发作起源的区域(通常定义为外科干预的目标),但癫痫发作的功能解剖结构也影响下游区域,并受到发作病灶输入的调节。了解癫痫发作网络,而不仅仅是发作焦点(异常处理会聚产生不受控制的活动),将是改善我们的外科干预和护理受影响个体的重要进展。然而,目前的方法,如临床MRI或EEG,以及神经病理学是不够的,以解决癫痫发作网络。因此,我们在这里建议调查使用中尺度MRI对切除的癫痫侧脑室,以揭示构成癫痫发作网络的解剖学变化。具体而言,我们的目标是:1)进一步开发基于扩散的MR组织学,以更好地区分细胞层和轴突连接,以及2)实现组织切片的三维重建,以验证纤维束成像重建。总体目标是提供一种方法,可以更好地描述癫痫发作网络,以提高我们对mTLE的理解,并通过改善鉴别诊断和术前计划,为接受颅内肿瘤切除术的患者带来切实的益处

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Michel M. Modo其他文献

Michel M. Modo的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Michel M. Modo', 18)}}的其他基金

MR Imaging of Bioscaffold-Induced Neural Progenitor Migration
生物支架诱导的神经祖细胞迁移的磁共振成像
  • 批准号:
    10428631
  • 财政年份:
    2021
  • 资助金额:
    $ 21.47万
  • 项目类别:
MR Imaging of Bioscaffold-Induced Neural Progenitor Migration
生物支架诱导的神经祖细胞迁移的磁共振成像
  • 批准号:
    10273779
  • 财政年份:
    2021
  • 资助金额:
    $ 21.47万
  • 项目类别:
MR Imaging of Bioscaffold-Induced Neural Progenitor Migration
生物支架诱导的神经祖细胞迁移的磁共振成像
  • 批准号:
    10653691
  • 财政年份:
    2021
  • 资助金额:
    $ 21.47万
  • 项目类别:
Enhancing Neurogenesis for Brain Tissue Regeneration
增强神经发生促进脑组织再生
  • 批准号:
    10217654
  • 财政年份:
    2021
  • 资助金额:
    $ 21.47万
  • 项目类别:
American Society for Neural Therapy and Repair
美国神经治疗与修复学会
  • 批准号:
    9125499
  • 财政年份:
    2016
  • 资助金额:
    $ 21.47万
  • 项目类别:
American Society for Neural Therapy and Repair
美国神经治疗与修复学会
  • 批准号:
    8908741
  • 财政年份:
    2015
  • 资助金额:
    $ 21.47万
  • 项目类别:
Non-invasive Imaging of the In Situ Restoration of Brain Tissue
脑组织原位修复的无创成像
  • 批准号:
    8756142
  • 财政年份:
    2014
  • 资助金额:
    $ 21.47万
  • 项目类别:
American Society for Neural Therapy and Repair
美国神经治疗与修复学会
  • 批准号:
    8714516
  • 财政年份:
    2014
  • 资助金额:
    $ 21.47万
  • 项目类别:
American Society for Neural Therapy and Repair
美国神经治疗与修复学会
  • 批准号:
    8528867
  • 财政年份:
    2013
  • 资助金额:
    $ 21.47万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 21.47万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 21.47万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 21.47万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 21.47万
  • 项目类别:
    Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 21.47万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 21.47万
  • 项目类别:
    Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 21.47万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 21.47万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 21.47万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 21.47万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了