Programs in HIV and AIDS-Associated Diseases/Malignancies

项目总结/摘要 本申请建议继续和扩大内布拉斯加大学的福格蒂国际 艾滋病毒和艾滋病相关恶性肿瘤培训方案（内布拉斯加州AITRP）。内布拉斯加的目标 AITRP将继续为赞比亚和中国的生物医学科学家和医疗保健提供培训 提供者，以提高他们的专业知识和能力，在执行高质量的生物医学，行为， 艾滋病毒和艾滋病相关疾病和恶性肿瘤的预防性研究。外国合作伙伴是 赞比亚大学医学院和大学教学医院，赞比亚卢萨卡;南开大学 中国天津大学;天津医科大学和肿瘤研究所和医院。 本次更新申请的目标是：1）继续建立艾滋病毒/艾滋病和相关疾病 赞比亚和中国的癌症和恶性肿瘤研究能力，以及2）扩大计划组成部分，以解决 对艾滋病及相关疾病预防、治疗和管理研究的不断发展的需求 由该计划的外国合作伙伴确定。将通过三个具体目标实现这些目标： 1)为内布拉斯加大学的赞比亚和中国研究员提供密集的学术指导 导致：i）病理学硕士，ii）癌症流行病学硕士，或iii）肿瘤病毒学硕士或博士，或 护理学 2)为赞比亚和中国研究员提供机会，参加生物医学研究轮换， 内布拉斯加大学和迈阿密大学在：1）基础研究艾滋病毒的作用，人类 乳头状瘤病毒（HPV）、卡波西肉瘤相关疱疹病毒（KSHV）和爱泼斯坦巴尔病毒（EBV）， 艾滋病相关恶性肿瘤的发展; ii）检测病原体的先进实验室方法 和监测艾滋病毒基因型; iii）与艾滋病毒相关的神经系统疾病的基础和临床研究 四）艾滋病疾病管理、抗病毒治疗、艾滋病诊断和 艾滋病和非艾滋病相关恶性肿瘤的治疗;和v）流行病学，数据分析， 制定和评估公共卫生干预战略。 3)提供流行病学、行为干预、艾滋病毒/艾滋病 发病机制，艾滋病相关疾病，实验室技术，伦理学和赠款/手稿准备。 内布拉斯加州病毒学中心，一个首屈一指的病毒学研究和培训中心，将管理该计划。

PROJECT SUMMARY/ABSTRACT This application proposes the continuation and expansion of the University of Nebraska's Fogarty International Training Program in HIV- and AIDS-Associated Malignancies (Nebraska AITRP). The goal of the Nebraska AITRP is to continue to provide training for Zambian and Chinese biomedical scientists and health care providers to increase their expertise and capability in performing high quality biomedical, behavioral, and preventative research on HIV- and AIDS-associated diseases and malignancies. Foreign partners are the University of Zambia School of Medicine and University Teaching Hospital in Lusaka, Zambia; Nankai University in Tianjin, China; and the Tianjin Medical University and the Cancer Institute and Hospital. The objectives of this renewal application are to 1) continue to build the HIV/AIDS and associated diseases and malignancies research capacity in Zambia and China, and 2) expand program components to address evolving needs in research on prevention, treatment, and management of AIDS and associated diseases identified by the program's foreign partners. The objectives will be accomplished through three specific aims: 1) Provide intensive academic instruction for Zambian and Chinese fellows at the University of Nebraska leading to a: i) MMed in pathology, ii) MPH in cancer epidemiology, or iii) MS or PhD in tumor virology or nursing. 2) Provide opportunities for Zambian and Chinese fellows to participate in biomedical research rotations at the University of Nebraska and the University of Miami in: 1) basic research on the role of HIV, human papilloma virus (HPV), Kaposi's sarcoma-associated herpesvirus (KSHV), and Epstein Barr virus (EBV) in the development of AIDS-associated malignancies; ii) advanced laboratory methods to detect pathogens and monitor HIV genotypes; iii) basic and clinical research on neurological diseases associated with HIV infection; iv) clinical research on disease management of AIDS, anti-viral treatments, and the diagnosis and treatment of AIDS and non AIDS-associated malignancies; and v) epidemiology, data analysis, and the development and evaluation of public health intervention strategies. 3) Provide in-country training, courses and workshops in epidemiology, behavioral interventions, HIV pathogenesis, AIDS-associated diseases, laboratory techniques, ethics, and grant/manuscript preparation. The Nebraska Center for Virology, a premier virology research and training center, will administer the program.