A Laser Microbeam Biotechnology Resource

描述（由申请人提供）：激光微束和医疗计划（LAMMP），致力于在生物学和医学中使用激光和光学。LAMMP位于贝克曼激光研究所和医疗诊所，一个跨学科的生物医学研究，教学和临床设施在加州大学欧文分校。LAMMP的活动范围从基础科学和技术开发到临床转化研究。这是通过将最先进的生物光子学技术与细胞和组织工程、组织病理学、临床前动物模型和临床护理的专业资源设施相结合来实现的。LAMMP计划包括生物光子学建模和技术开发，基础科学研究，仪器原型设计以及人类和动物模型的设备测试。由于我们的设施，资源和专业知识，我们能够快速地将新概念和技术从黑板转移到桌面再到床边。在LAMMP的第七次更新申请中，我们继续通过推进几项新技术和高影响力的合作来改造我们的中心。我们建议将我们的活动整合到技术研发（TR&D）的4个主要领域：虚拟光子技术（VPT），显微镜和微束技术（MMT），多模态内窥镜技术（MET）和漫射光学技术（DOT）。为每个TR&D核心提出了具体的目标，这些目标将导致开发几种最先进的技术、仪器和 计算方法这四个TR&D核心包含互补的、相互依赖的方法，用于定量表征、成像和扰动细胞和组织中的结构和生化功能，具有可扩展的分辨率和深度灵敏度，范围从微米到厘米。我们的广泛目标是通过合作，服务，培训和传播活动来推进这些技术，使它们成为广泛可用的，能够解决生物学和医学中重要问题的方法。

DESCRIPTION (provided by applicant): The Laser Microbeam and Medical Program (LAMMP), is dedicated to the use of lasers and optics in Biology and Medicine. LAMMP is located within the Beckman Laser Institute and Medical Clinic, an interdisciplinary biomedical research, teaching, and clinical facility at the University of California, Irvine. LAMMP activities span from basic science and technology development to clinical translational research. This is accomplished by combining state of the art Biophotonics technologies with specialized resource facilities for cell and tissue engineering, histopathology, pre-clinical animal models, and clinica care. LAMMP programs include Biophotonics modeling and technology development, basic science studies, instrument prototyping, and device testing in humans and animal models. Because of our facilities, resources, and expertise, we are able to rapidly move new concepts and technologies from blackboard to bench-top to bedside. In this seventh renewal application of LAMMP, we continue to transform our center by advancing several new technologies and high-impact collaborations. We propose to consolidate our activities into 4 major areas of Technology Research and Development (TR&D): Virtual Photonics Technologies (VPT), Microscopy and Microbeam Technologies (MMT), Multimodality Endoscopic Technologies (MET), and Diffuse Optics Technologies (DOT). Specific Aims are proposed for each TR&D core that will result in the development of several state-of-the-art technologies, instruments, and computational methods. Together, the four TR&D cores contain complementary, inter-dependent approaches for quantitatively characterizing, imaging, and perturbing structure and biochemical function in cells and tissues with scalable resolution and depth sensitivity ranging from micrometers to centimeters. Our broad goal is to advance these technologies through collaboration, service, training, and dissemination activities so they become widely-available, enabling methods for solving important problems in Biology and Medicine.