A Laser Microbeam Biotechnology Resource

描述（由申请人提供）：激光微束和医学项目（LAMMP），致力于在生物和医学中使用激光和光学。LAMMP位于贝克曼激光研究所和医学诊所内，这是加州大学欧文分校的跨学科生物医学研究、教学和临床设施。LAMMP的活动范围从基础科学和技术开发到临床转化研究。这是通过将最先进的生物光子学技术与细胞和组织工程、组织病理学、临床前动物模型和临床护理的专业资源设施相结合来实现的。LAMMP项目包括生物光子学建模和技术开发、基础科学研究、仪器原型设计以及人类和动物模型的设备测试。由于我们的设施、资源和专业知识，我们能够迅速将新概念和技术从黑板转移到桌面再到床边。在LAMMP的第七次更新应用中，我们继续通过推进几项新技术和高影响力的合作来改造我们的中心。我们建议将我们的活动整合到四个主要的技术研发领域：虚拟光子学技术（VPT），显微镜和微光束技术（MMT），多模态内窥镜技术（MET）和漫射光学技术（DOT）。为每个研发核心提出了具体目标，这将导致几种最先进的技术、仪器和技术的发展

DESCRIPTION (provided by applicant): The Laser Microbeam and Medical Program (LAMMP), is dedicated to the use of lasers and optics in Biology and Medicine. LAMMP is located within the Beckman Laser Institute and Medical Clinic, an interdisciplinary biomedical research, teaching, and clinical facility at the University of California, Irvine. LAMMP activities span from basic science and technology development to clinical translational research. This is accomplished by combining state of the art Biophotonics technologies with specialized resource facilities for cell and tissue engineering, histopathology, pre-clinical animal models, and clinica care. LAMMP programs include Biophotonics modeling and technology development, basic science studies, instrument prototyping, and device testing in humans and animal models. Because of our facilities, resources, and expertise, we are able to rapidly move new concepts and technologies from blackboard to bench-top to bedside. In this seventh renewal application of LAMMP, we continue to transform our center by advancing several new technologies and high-impact collaborations. We propose to consolidate our activities into 4 major areas of Technology Research and Development (TR&D): Virtual Photonics Technologies (VPT), Microscopy and Microbeam Technologies (MMT), Multimodality Endoscopic Technologies (MET), and Diffuse Optics Technologies (DOT). Specific Aims are proposed for each TR&D core that will result in the development of several state-of-the-art technologies, instruments, and computational methods. Together, the four TR&D cores contain complementary, inter-dependent approaches for quantitatively characterizing, imaging, and perturbing structure and biochemical function in cells and tissues with scalable resolution and depth sensitivity ranging from micrometers to centimeters. Our broad goal is to advance these technologies through collaboration, service, training, and dissemination activities so they become widely-available, enabling methods for solving important problems in Biology and Medicine.