China-America MRI Plaque Imaging & Outcome Network (ChAMPION)

 描述(申请人提供)：中风是世界第二大死因，也是中国的第一大死因。在中国和世界范围内，大多数中风是由颅内动脉粥样硬化(ICAS)引起的。尽管ICAS对公众健康产生了巨大的影响，但ICAS的病理生理机制尚未得到很好的了解，尽管有可用的治疗方法，但中风的风险很高。高分辨率(HR)MRI已成为研究ICAS的病理生理学和体内治疗反应的潜在工具。然而，为了推进HRMRI ICAS研究领域的发展，需要建立一个国际多中心网络，为促进协作、协议和数据共享提供研究基础设施，并为ICAS的HRMRI研究提供快速有效的机制。我们的目标是通过在北京初步建立一个中央协调中心，在中国和北美建立这样一个合作的国际HRMRI ICAS研究网络，该中心将领导 中国遗址10处。在这项建议中，我们的目标是：1.评估当前的研究需求和能力，以在中国进行有效和可靠的高分辨磁共振成像序列；2.建立必要的研究基础设施，进行国际多中心高分辨磁共振ICAS成像，包括使用创新的成像模体在各个部位建立可靠的图像质量；3.为设计一项多中心国际研究计划、准备和获取初步数据，该研究将评估高分辨磁共振成像斑块特征与复发中风风险之间的关系，以及当前可用的药物治疗(如他汀类药物)如何影响这种关系。通过实现这些目标，我们将建立一个可持续合作的国际HRMRI研究网络，为未来的HRMRI研究提供一个平台。这将为研究颅内动脉粥样硬化引起的中风的病理生理机制提供新的见解，我们预计这将为中国和世界范围内中风的主要原因带来新的预防性治疗方法。

 DESCRIPTION (provided by applicant): Stroke is the second leading cause of death worldwide and the leading cause of death in China. The majority of strokes in China and worldwide are due to intracranial atherosclerosis (ICAS). Despite the enormous public health impact of ICAS, the pathophysiology of ICAS is not well understood and the risk of stroke is high despite available treatments. High resolution (HR) MRI has emerged as a potential tool to study the pathophysiology of ICAS and the response to treatment in vivo. However, in order to advance the field of HRMRI ICAS research, establishment of an international multicenter network to provide the research infrastructure for promoting collaboration, sharing of protocols and data, and providing a quick and efficient mechanism for studying HRMRI in ICAS is needed. We aim to develop such a collaborative international HRMRI ICAS research network in China and North America by initially establishing a Central Coordinating Center in Beijing that will lead 10 China sites. In this proposal we aim to: 1. Assess current research needs and capabilities to perform valid and reliable HRMRI sequences in China, 2. Establish the necessary research infrastructure to perform international multicenter HRMRI ICAS imaging, including establishing reliable image quality at the sites by using an innovative imaging phantom, and 3. Plan, prepare, and obtain preliminary data for the design of a multicenter international study that will evaluate the relationship between HRMRI plaque features and recurrent stroke risk and how currently available medical therapy, such as statins, influences that relationship. By achieving these aims we will develop a sustainable collaborative international HRMRI research network that will provide a platform for future HRMRI studies. This will provide new insights into the pathophysiology of stroke due to intracranial atherosclerosis, which we expect will lead to new preventive treatments for the leading cause of stroke in China and worldwide.