China-America MRI Plaque Imaging & Outcome Network (ChAMPION)

 描述（由申请人提供）：卒中是全球第二大死亡原因，也是中国的主要死亡原因。中国和世界范围内的大多数卒中是由于颅内动脉粥样硬化（ICAS）。尽管ICAS对公共卫生有巨大影响，但ICAS的病理生理学尚未得到很好的理解，尽管有可用的治疗方法，但中风的风险仍然很高。高分辨率（HR）MRI已成为研究ICAS病理生理学和体内治疗反应的潜在工具。然而，为了推进HRMRI ICAS研究领域的发展，需要建立一个国际多中心网络，为促进合作、共享协议和数据提供研究基础设施，并为ICAS中的HRMRI研究提供快速有效的机制。我们的目标是在中国和北美建立这样一个合作性的国际HRMRI ICAS研究网络，首先在北京建立一个中央协调中心， 10个中国研究中心。在本提案中，我们的目标是：1。评估目前的研究需求和能力，以执行有效和可靠的HRMRI序列在中国，2。建立必要的研究基础设施，以执行国际多中心HRMRI ICAS成像，包括通过使用创新的成像体模在研究中心建立可靠的图像质量，以及3。计划、准备和获得多中心国际研究设计的初步数据，该研究将评估HRMRI斑块特征与复发性卒中风险之间的关系，以及目前可用的药物治疗（如他汀类药物）如何影响这种关系。通过实现这些目标，我们将开发一个可持续的合作国际HRMRI研究网络，为未来的HRMRI研究提供一个平台。这将为颅内动脉粥样硬化所致卒中的病理生理学提供新的见解，我们预计这将为中国和全球卒中的主要原因带来新的预防性治疗。

 DESCRIPTION (provided by applicant): Stroke is the second leading cause of death worldwide and the leading cause of death in China. The majority of strokes in China and worldwide are due to intracranial atherosclerosis (ICAS). Despite the enormous public health impact of ICAS, the pathophysiology of ICAS is not well understood and the risk of stroke is high despite available treatments. High resolution (HR) MRI has emerged as a potential tool to study the pathophysiology of ICAS and the response to treatment in vivo. However, in order to advance the field of HRMRI ICAS research, establishment of an international multicenter network to provide the research infrastructure for promoting collaboration, sharing of protocols and data, and providing a quick and efficient mechanism for studying HRMRI in ICAS is needed. We aim to develop such a collaborative international HRMRI ICAS research network in China and North America by initially establishing a Central Coordinating Center in Beijing that will lead 10 China sites. In this proposal we aim to: 1. Assess current research needs and capabilities to perform valid and reliable HRMRI sequences in China, 2. Establish the necessary research infrastructure to perform international multicenter HRMRI ICAS imaging, including establishing reliable image quality at the sites by using an innovative imaging phantom, and 3. Plan, prepare, and obtain preliminary data for the design of a multicenter international study that will evaluate the relationship between HRMRI plaque features and recurrent stroke risk and how currently available medical therapy, such as statins, influences that relationship. By achieving these aims we will develop a sustainable collaborative international HRMRI research network that will provide a platform for future HRMRI studies. This will provide new insights into the pathophysiology of stroke due to intracranial atherosclerosis, which we expect will lead to new preventive treatments for the leading cause of stroke in China and worldwide.