Core C - Biostatistics Core

抽象-核心C 卵巢孢子生物统计核心提供统计协作和数据管理支持 每一个主要的孢子项目、发展研究和职业发展项目以及 其他核心。在1-5年中，核心成员与孢子研究人员密切合作，以促进 优化研究设计，制定分析计划，并解释结果。生物统计学核心成员一直是 在资助的头五年里，孢子出版社136种出版物中的三分之一以上都有作者。此外, 核心成员还通过迁移两个以前存在的用于临床的数据库来改进数据基础架构 数据和患者登记数据放入一个卵巢临床数据库(OvCD)。这一迁移导致了 提高了生物统计核心成员以及研究协调员工作人员的效率。这个数据库是 不仅被卵巢孢子研究人员使用，也被机构卵巢癌研究人员使用。这是一个 它是准确、最新信息的来源，并促进了孢子间的合作。 在这次更新中，生物统计核心非常积极地为每个项目编制统计计划。 生物统计核心将继续向每个孢子调查员保证获得统计专业知识 包括协作开发研究设计和分析计划、最先进的数据分析和 口译、数据管理资源、摘要和手稿准备。建议的项目 跨越了广泛的方法和分析。此外，核心成员将继续改进现有的 数据库基础设施，包括继续开发患者来源的异种移植(阿凡达)数据库 这是对现有OvCD的补充，并将使阿凡达数据与现有OvCD同步。生物统计学的核心 以梅奥诊所开发的创新和经过时间考验的程序和系统为基础，梅奥诊所是 全国最大的统计小组，其成员在临床和基础科学方面进行合作 自1932年以来的研究工作。这一核心补充和协助了生物检验师/患者的努力 注册表核心和动物模型核心，提供卓越的数据管理和体验 生物制品登记处。 通过这些合作活动，生物统计核心将有助于确保这一孢子的研究是 以高效、有效和严格的方式执行。

ABSTRACT – Core C The Ovarian SPORE Biostatistics Core provides statistical collaboration and data management support for each of the main SPORE projects, the Developmental Research and Career Development projects, and the other Cores. In Years 1-5, Core members have collaborated heavily with SPORE researchers to facilitate optimal study design, create analysis plans, and interpret results. Biostatistics Core members have been co- authors on more than a third of the SPORE's 136 publications in the first five years of funding. In addition, Core members also improved the data infrastructure by migrating two previously existing databases for clinical data and patient registration data into one Ovarian Clinical Database (OvCD). This migration has resulted in improved efficiencies for Biostatistics Core members as well as study coordinator staff. This database is utilized not only by Ovarian SPORE researchers, but also by institutional ovarian cancer researchers. It is a source of accurate, up-to-date information and has facilitated inter-SPORE collaborations. In this renewal, the Biostatistics Core has been very active in preparing the statistical plan for each Project. The Biostatistics Core will continue to assure each SPORE investigator access to statistical expertise that includes collaborative development of study designs and analysis plans, state-of-the-art data analysis and interpretation, data management resources, and abstract and manuscript preparation. The proposed projects span a wide range of approaches and analyses. In addition, Core members will continue to improve existing database infrastructure, including continued development of a patient derived xenograft (Avatar) database which is complementary to and will synchronize Avatar data with the existing OvCD. The Biostatistics Core builds upon the innovative and time-tested procedures and systems developed by Mayo Clinic, one of the largest statistical groups in the country, whose members have collaborated on clinical and basic science research studies since 1932. This Core complements and assists the efforts of the Biospecimens/Patient Registry Core and Animal Models Core by providing superior data management and experience with biospecimen registries. Through these collaborative activities, the Biostatistics Core will help assure that research in this SPORE is carried out in an efficient, effective, and rigorous manner.