Core C: Biostatistics and Informatics

核心C：生物统计学和信息学

• 批准号: 10268761
• 负责人: Ann Laura Oberg
• 金额: $ 24.29万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2026-08-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10268761
• 关键词: Animal Model; Archives; Basic Science; Bioinformatics; Biometry; Clinic; Clinical; Clinical Sciences; Clinical Trials; Collaborations; Complement; Country; Data; Data Analyses; Data Collection; Data Management Resources; Database Management Systems; Databases; Development; Ensure; Experimental Designs; Informatics; Infrastructure; Malignant neoplasm of ovary; Manuscripts; Measurement; Methods; Monitor; Ovarian; Patients; Preparation; Procedures; Quality Control; Randomized; Registries; Reporting; Reproducibility; Research; Research Design; Research Methodology; Research Personnel; Resources; Safety; Sample Size; Scheme; Source; System; Testing; Time; analytical tool; career; data infrastructure; data management; data quality; data sharing; design; experience; improved; innovation; instrumentation; member; migration; patient derived xenograft model; patient registry; programs; research study; sound; study population; tool

ABSTRACT – BIOSTATISTICS AND BIOINFORMATICS CORE (CORE C) The Ovarian SPORE Biostatistics and Bioinformatics Core provides statistical and bioinformatic collaboration and data management support for each of the main SPORE projects, the Developmental Research Program (DRP) and Career Enhancement Program (CEP) projects, and the other Cores. As in Years 1-5, Core C members have continued in Years 6-10 to collaborate heavily with SPORE researchers to facilitate optimal study design, create analysis plans, and interpret results. In addition, Core members also improved the data infrastructure by consolidating the biospecimens, clinical and animal models databases into one comprehensive data management system. This migration has resulted in improved efficiencies for Biostatistics and Bioinformatics Core members as well as Animal Models Core members, Biospecimens and Patient Registry Core members, and study coordinator staff. This database system is utilized not only by Ovarian SPORE researchers, but also by institutional ovarian cancer researchers. It is a source of accurate, up-to-date information and has facilitated both intra- and inter-SPORE collaborations. Members also developed an improved investigator request portal and tracking database for SPORE biospecimen and core resource requests. In this renewal, the Biostatistics and Bioinformatics Core will be very active in preparing the analytical plan for each Project. The proposed projects are expected to span a wide range of approaches and analyses. The Biostatistics and Bioinformatics Core will continue to assure each SPORE investigator access to statistical and bioinformatic expertise that includes collaborative development of study designs and analysis plans, state-of- the-art data analysis and interpretation, data management resources, and abstract and manuscript preparation. In addition, Core members will continue to improve existing database infrastructure. The Biostatistics and Bioinformatics Core builds upon the innovative and time-tested procedures and systems developed by Mayo Clinic, one of the largest statistical groups in the country, whose members have collaborated on clinical and basic science research studies since 1932. This Core complements and assists the efforts of the Biospecimens and Patient Registry Core and Animal Models Core by providing superior data management and experience with biospecimen registries. Through these collaborative activities, the Biostatistics and Bioinformatics Core will help ensure that research in this SPORE is carried out in an efficient, effective, and rigorous manner.

摘要 – 生物统计学和生物信息学核心（核心 C） 卵巢孢子生物统计学和生物信息学核心提供统计和生物信息学协作 以及对每个主要 SPORE 项目、发展研究计划的数据管理支持 （DRP）和职业提升计划（CEP）项目，以及其他核心。与 1-5 年一样，核心 C 成员在第 6-10 年继续与 SPORE 研究人员密切合作，以促进最佳 研究设计、创建分析计划并解释结果。此外，核心成员还完善了数据 通过将生物样本、临床和动物模型数据库整合为一个基础设施 综合数据管理系统。这种迁移提高了生物统计的效率 和生物信息学核心成员以及动物模型核心成员、生物样本和患者 注册中心核心成员和研究协调员。该数据库系统不仅被 Ovarian 使用 SPORE 研究人员，也包括卵巢癌机构的研究人员。它是准确、最新的信息来源 信息并促进了 SPORE 内部和 SPORE 之间的合作。成员们还制定了 改进了 SPORE 生物样本和核心资源的研究者请求门户和跟踪数据库 请求。 在这次更新中，生物统计学和生物信息学核心将非常积极地准备分析计划 每个项目。拟议的项目预计将涵盖广泛的方法和分析。这 生物统计学和生物信息学核心将继续确保每个 SPORE 研究者能够获得统计和信息 生物信息专业知识，包括研究设计和分析计划的协作开发、现状 最先进的数据分析和解释、数据管理资源以及摘要和手稿 准备。此外，核心成员将继续改进现有的数据库基础设施。这 生物统计学和生物信息学核心建立在创新且经过时间考验的程序和系统的基础上 由美国最大的统计集团之一梅奥诊所开发，其成员 自 1932 年以来一直在临床和基础科学研究方面进行合作。该核心补充和协助 生物样本和患者登记核心和动物模型核心通过提供优质数据做出的努力 生物样本注册管理和经验。通过这些协作活动， 生物统计学和生物信息学核心将有助于确保该 SPORE 的研究以高效、 有效、严谨的方式。