Core C: Biostatistics and Informatics

摘要--生物统计学和生物信息学核心(核心C) 卵巢孢子生物统计和生物信息学核心提供统计和生物信息协作 以及对每个主要孢子项目、发展研究方案的数据管理支持 (DRP)和职业提升计划(CEP)项目，以及其他核心项目。如在第1-5年，核心C 成员在6-10年间继续与孢子研究人员密切合作，以促进最佳 研究设计，创建分析计划，并解释结果。此外，核心成员也对数据进行了改进 基础设施，将生物检疫、临床和动物模型数据库合并为一个数据库 全面的数据管理系统。这种迁移提高了生物统计学的效率 和生物信息学核心成员以及动物模型核心成员、生物标本和患者 登记处核心成员和研究协调员工作人员。这个数据库系统不仅被卵巢公司使用 孢子研究人员，也由机构卵巢癌研究人员。它是一个准确的、最新的来源 信息，并促进了孢子内和孢子间的合作。成员们还开发了一种 改进了孢子生物样品和核心资源的调查者请求门户和跟踪数据库 请求。 在这次更新中，生物统计和生物信息学核心将非常积极地编制分析计划 每个项目。预计拟议的项目将涉及广泛的方法和分析。这个 生物统计和生物信息学核心将继续确保每个孢子调查员获得统计和 生物信息学专业知识，包括研究设计和分析计划的协作开发， 最先进的数据分析和解释，数据管理资源，摘要和手稿 准备工作。此外，核心成员将继续改善现有的数据库基础设施。这个 生物统计和生物信息学核心建立在创新和经过时间考验的程序和系统的基础上 由梅奥诊所开发，梅奥诊所是该国最大的统计组织之一，其成员 自1932年以来，在临床和基础科学研究方面进行合作。这一核心是补充和协助 生物学家、患者登记核心和动物模型核心通过提供卓越的数据所做的努力 生物检疫登记的管理和经验。通过这些协作活动， 生物统计学和生物信息学核心将有助于确保在这个孢子中的研究在一个高效、 高效，严谨的态度。

ABSTRACT – BIOSTATISTICS AND BIOINFORMATICS CORE (CORE C) The Ovarian SPORE Biostatistics and Bioinformatics Core provides statistical and bioinformatic collaboration and data management support for each of the main SPORE projects, the Developmental Research Program (DRP) and Career Enhancement Program (CEP) projects, and the other Cores. As in Years 1-5, Core C members have continued in Years 6-10 to collaborate heavily with SPORE researchers to facilitate optimal study design, create analysis plans, and interpret results. In addition, Core members also improved the data infrastructure by consolidating the biospecimens, clinical and animal models databases into one comprehensive data management system. This migration has resulted in improved efficiencies for Biostatistics and Bioinformatics Core members as well as Animal Models Core members, Biospecimens and Patient Registry Core members, and study coordinator staff. This database system is utilized not only by Ovarian SPORE researchers, but also by institutional ovarian cancer researchers. It is a source of accurate, up-to-date information and has facilitated both intra- and inter-SPORE collaborations. Members also developed an improved investigator request portal and tracking database for SPORE biospecimen and core resource requests. In this renewal, the Biostatistics and Bioinformatics Core will be very active in preparing the analytical plan for each Project. The proposed projects are expected to span a wide range of approaches and analyses. The Biostatistics and Bioinformatics Core will continue to assure each SPORE investigator access to statistical and bioinformatic expertise that includes collaborative development of study designs and analysis plans, state-of- the-art data analysis and interpretation, data management resources, and abstract and manuscript preparation. In addition, Core members will continue to improve existing database infrastructure. The Biostatistics and Bioinformatics Core builds upon the innovative and time-tested procedures and systems developed by Mayo Clinic, one of the largest statistical groups in the country, whose members have collaborated on clinical and basic science research studies since 1932. This Core complements and assists the efforts of the Biospecimens and Patient Registry Core and Animal Models Core by providing superior data management and experience with biospecimen registries. Through these collaborative activities, the Biostatistics and Bioinformatics Core will help ensure that research in this SPORE is carried out in an efficient, effective, and rigorous manner.