Resource Core 1: Experimental Core

资源核心 1：实验核心

• 批准号: 8982184
• 负责人: Liz Simon
• 金额: $ 62.31万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8982184
• 关键词: AIDS/HIV problem; Alcohol consumption; Alcohols; Ambulatory Care Facilities; Animals; Award; Basic Science; Behavioral; Biological; Caring; Center for Translational Science Activities; Chronic; Clinical; Clinical Data; Clinical Research; Clinical Sciences; Collaborations; Consent; Data; Data Collection; Disease; Enrollment; Ensure; Environment; Equipment and supply inventories; Ethics; Goals; HIV; Human Resources; Individual; Leadership; Life; Longitudinal Studies; Louisiana; Macaca mulatta; Modeling; Monitor; NCI Center for Cancer Research; Participant; Pathogenesis; Pattern; Persons; Pilot Projects; Play; Postdoctoral Fellow; Preparation; Procedures; Quality Control; Quality of Care; Recruitment Activity; Research; Research Design; Research Personnel; Research Project Grants; Resources; Role; SIV; Sampling; Scientist; Secure; Teacher Professional Development; Training; Training Support; Translational Research; University Hospitals; Veterinarians; Work; abstracting; alcohol research; alcohol use disorder; animal care; behavior measurement; knowledge translation; nonhuman primate; pre-clinical; pre-doctoral; preclinical study; research study; translational study; viral transmission

Abstract LSUHSC CARC Experimental Core The Experimental Core of the LSUHSC Comprehensive Alcohol Research Center (CARC) is comprised of a Pre-clinical Non-Human Primate Research (NHPR) Unit and a Clinical Translational Research (CTR) Unit. The Experimental Core will support all translational preclinical and clinical studies proposed by the Research Components (RC) and Pilot Projects in this application. The Experimental Core will coordinate and execute all experimental procedures for pre-clinical studies using our established chronic binge alcohol (CBA) Simian Immunodeficiency Virus (SIV) non-human primate (NHP) model and proposed clinical studies in persons living with HIV/AIDS (PLWHA). The overall goal of the Experimental Core is to provide high quality care, treatment, monitoring and use of NHP in CBA/SIV studies, and to coordinate and conduct translational studies in order to examine the impact of alcohol use disorders (AUD), including alcohol consumption patterns on comorbid conditions in PLWHA. The Experimental Core will work in close collaboration with the Analytical Core to manage and optimize the transfer of biological, clinical, and behavioral data collected for storage, preparation, and analysis. The Experimental Core will promote cooperation, efficiency, quality control, and translational abilities for CARC investigators. The Specific Aims (SA) of the Core are: 1) To provide leadership, management and coordination for preclinical and clinical translational studies; 2) To coordinate and execute NHPR studies; 3) To recruit, consent, and enroll study participants and conduct clinical cross-sectional and longitudinal studies; 4) To coordinate biospecimen and data collection, from pre-clinical and clinical studies, and their transfer to the Analytical Core; 5) To participate in the training of faculty, pre- and post-doctoral fellows, and staff performing research in the NHP model of CBA/SIV or in PLWHA. The CARC Experimental Core will further support CARC investigators through: a) ensuring regulatory compliance for all pre-clinical and clinical studies conducted by individual RC and Pilot Projects; b) facilitate bidirectional translational opportunities between basic and clinical researchers; c) training of personnel and trainees working on CARC alcohol research projects in the use of NHP and on the basics of clinical research; d) ensuring collection of data for clinical sub-aims proposed by RC1 and RC2; e) providing CARC investigators opportunities to expand the scope of research on the impact of AUD on SIV/HIV disease; and f) facilitating CARC investigator interaction with LSUHSC Division of Animal Care (DAC), the HIV Outpatient (HOP) Clinic, and the University Hospital Clinical Translational Research Center (CTRC). The Experimental Core will synergize with existing LSUHSC resources including the DAC, CTRC and the Louisiana Clinical and Translational Science Award (LA CaTS), and the Louisiana Cancer Research Center. The Experimental Core will leverage the existing excellent basic science environment and expertise of our investigators and transform and expand our research approach to involve clinical research, allowing translation of knowledge gained from our NHP basic science studies.

摘要LSUHSC CARC实验核心 LSUHSC综合酒精研究中心（CARC）的实验核心由 临床前非人类灵长类动物研究（NHPR）和临床转化研究（CTR） 单元。实验核心将支持所有由 该应用程序中的研究组件（RC）和试点项目。实验核心将协调和 使用我们已建立的慢性酒精（CBA）执行所有用于临床前研究的实验程序 猿猴免疫缺陷病毒（SIV）非人类灵长类动物（NHP）模型和拟议的临床研究 患有艾滋病毒/艾滋病的人（PLWHA）。实验核心的总体目标是提供高质量 在CBA/SIV研究中，NHP的护理，治疗，监测和使用，并协调和进行翻译 研究以检查酒精使用障碍的影响（AUD），包括酒精消耗模式 关于PLWHA的合并条件。实验核心将与分析密切合作 核心以管理和优化用于存储的生物学，临床和行为数据的转移， 准备和分析。实验核心将促进合作，效率，质量控制，并 CARC调查人员的翻译能力。核心的具体目的（SA）是：1）提供领导才能， 临床前和临床翻译研究的管理与协调； 2）协调和执行 NHPR研究； 3）招募，同意和注册研究参与者并进行临床横断面和 纵向研究； 4）从临床前和临床研究中协调生物测量和数据收集， 并将其转移到分析核心； 5）参加教师，前后的培训 研究员以及在CBA/SIV或PLWHA的NHP模型中进行研究的工作人员。 CARC实验 核心将通过以下方式进一步支持CARC调查人员：）确保所有前临床前和 单个RC和试点项目进行的临床研究； b）促进双向翻译 基础研究人员和临床研究人员之间的机会； c）培训从事CARC的人员和受训者 酒精研究项目用于使用NHP和临床研究的基础知识； d）确保收集 RC1和RC2提出的临床子AIM的数据； e）为CARC调查人员提供扩展的机会 关于AUD对SIV/HIV疾病影响的研究范围； f）促进CARC调查员 与LSUHSC动物护理部（DAC），HIV门诊（HOP）诊所和大学的相互作用 医院临床翻译研究中心（CTRC）。实验核心将与现有 LSUHSC资源包括DAC，CTRC和路易斯安那州临床和转化科学奖（LA） 猫）和路易斯安那州癌症研究中心。实验核心将利用现有的优秀 基础科学环境和研究人员的专业知识，并改变和扩展我们的研究方法 涉及临床研究，允许从我们的NHP基础科学研究中获得的知识翻译。