Resource Core 1: Experimental Core
资源核心 1:实验核心
基本信息
- 批准号:8982184
- 负责人:
- 金额:$ 62.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AIDS/HIV problemAlcohol consumptionAlcoholsAmbulatory Care FacilitiesAnimalsAwardBasic ScienceBehavioralBiologicalCaringCenter for Translational Science ActivitiesChronicClinicalClinical DataClinical ResearchClinical SciencesCollaborationsConsentDataData CollectionDiseaseEnrollmentEnsureEnvironmentEquipment and supply inventoriesEthicsGoalsHIVHuman ResourcesIndividualLeadershipLifeLongitudinal StudiesLouisianaMacaca mulattaModelingMonitorNCI Center for Cancer ResearchParticipantPathogenesisPatternPersonsPilot ProjectsPlayPostdoctoral FellowPreparationProceduresQuality ControlQuality of CareRecruitment ActivityResearchResearch DesignResearch PersonnelResearch Project GrantsResourcesRoleSIVSamplingScientistSecureTeacher Professional DevelopmentTrainingTraining SupportTranslational ResearchUniversity HospitalsVeterinariansWorkabstractingalcohol researchalcohol use disorderanimal carebehavior measurementknowledge translationnonhuman primatepre-clinicalpre-doctoralpreclinical studyresearch studytranslational studyviral transmission
项目摘要
Abstract LSUHSC CARC Experimental Core
The Experimental Core of the LSUHSC Comprehensive Alcohol Research Center (CARC) is comprised of a
Pre-clinical Non-Human Primate Research (NHPR) Unit and a Clinical Translational Research (CTR)
Unit. The Experimental Core will support all translational preclinical and clinical studies proposed by the
Research Components (RC) and Pilot Projects in this application. The Experimental Core will coordinate and
execute all experimental procedures for pre-clinical studies using our established chronic binge alcohol (CBA)
Simian Immunodeficiency Virus (SIV) non-human primate (NHP) model and proposed clinical studies in
persons living with HIV/AIDS (PLWHA). The overall goal of the Experimental Core is to provide high quality
care, treatment, monitoring and use of NHP in CBA/SIV studies, and to coordinate and conduct translational
studies in order to examine the impact of alcohol use disorders (AUD), including alcohol consumption patterns
on comorbid conditions in PLWHA. The Experimental Core will work in close collaboration with the Analytical
Core to manage and optimize the transfer of biological, clinical, and behavioral data collected for storage,
preparation, and analysis. The Experimental Core will promote cooperation, efficiency, quality control, and
translational abilities for CARC investigators. The Specific Aims (SA) of the Core are: 1) To provide leadership,
management and coordination for preclinical and clinical translational studies; 2) To coordinate and execute
NHPR studies; 3) To recruit, consent, and enroll study participants and conduct clinical cross-sectional and
longitudinal studies; 4) To coordinate biospecimen and data collection, from pre-clinical and clinical studies,
and their transfer to the Analytical Core; 5) To participate in the training of faculty, pre- and post-doctoral
fellows, and staff performing research in the NHP model of CBA/SIV or in PLWHA. The CARC Experimental
Core will further support CARC investigators through: a) ensuring regulatory compliance for all pre-clinical and
clinical studies conducted by individual RC and Pilot Projects; b) facilitate bidirectional translational
opportunities between basic and clinical researchers; c) training of personnel and trainees working on CARC
alcohol research projects in the use of NHP and on the basics of clinical research; d) ensuring collection of
data for clinical sub-aims proposed by RC1 and RC2; e) providing CARC investigators opportunities to expand
the scope of research on the impact of AUD on SIV/HIV disease; and f) facilitating CARC investigator
interaction with LSUHSC Division of Animal Care (DAC), the HIV Outpatient (HOP) Clinic, and the University
Hospital Clinical Translational Research Center (CTRC). The Experimental Core will synergize with existing
LSUHSC resources including the DAC, CTRC and the Louisiana Clinical and Translational Science Award (LA
CaTS), and the Louisiana Cancer Research Center. The Experimental Core will leverage the existing excellent
basic science environment and expertise of our investigators and transform and expand our research approach
to involve clinical research, allowing translation of knowledge gained from our NHP basic science studies.
摘要LSUHSC CARC实验核心
LSUHSC综合酒精研究中心(CARC)的实验核心由一个
临床前非人灵长类动物研究(NHPR)单位和临床转化研究(CTR)
单位实验核心将支持所有翻译临床前和临床研究提出的
研究组件(RC)和试点项目在此应用程序。实验核心将协调和
使用我们已建立的慢性酗酒(CBA)执行临床前研究的所有实验程序
猴免疫缺陷病毒(SIV)非人灵长类动物(NHP)模型和拟定的临床研究
艾滋病毒/艾滋病感染者。实验核心的总体目标是提供高质量的
在CBA/SIV研究中护理、治疗、监测和使用NHP,并协调和进行翻译
研究,以检查酒精使用障碍(AUD)的影响,包括酒精消费模式
艾滋病毒感染者和艾滋病患者的共病情况。实验核心将与分析中心密切合作,
核心管理和优化收集的生物、临床和行为数据的传输,
准备和分析。实验核心将促进合作,效率,质量控制,
CARC研究人员的翻译能力。核心的具体目标(SA)是:1)提供领导,
管理和协调临床前和临床转化研究; 2)协调和执行
NHPR研究; 3)招募、同意和登记研究参与者,并进行临床横断面和
纵向研究; 4)协调临床前和临床研究的生物样本和数据收集,
及其转移到分析核心; 5)参加教师,前和博士后的培训
研究员和在CBA/SIV或PLWHA的NHP模型中进行研究的工作人员。CARC实验
核心将通过以下方式进一步支持CARC研究人员:a)确保所有临床前和临床试验的合规性,
由单个RC和试点项目进行的临床研究; B)促进双向翻译
基础和临床研究人员之间的机会; c)培训CARC工作人员和受训人员
关于使用NHP和临床研究基础的酒精研究项目; d)确保收集
RC 1和RC 2提出的临床子目标的数据; e)为CARC研究者提供扩展
AUD对SIV/HIV疾病影响的研究范围;以及f)促进CARC研究人员
与LSUHSC动物护理部(DAC),HIV门诊(HOP)诊所和大学的互动
医院临床转化研究中心(CTRC)。实验核心将与现有的
LSUHSC资源,包括DAC、CTRC和路易斯安那州临床和转化科学奖(LA
CaTS)和路易斯安那州癌症研究中心。实验核心将利用现有的优秀
我们的研究人员的基础科学环境和专业知识,并改变和扩大我们的研究方法
涉及临床研究,允许翻译从我们的NHP基础科学研究中获得的知识。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Liz Simon的其他文献
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{{ truncateString('Liz Simon', 18)}}的其他基金
Alcohol and dysfunctional skeletal muscle mass: implications in aging
酒精和骨骼肌质量功能障碍:对衰老的影响
- 批准号:
10811081 - 财政年份:2023
- 资助金额:
$ 62.31万 - 项目类别:
Alcohol-induced myomiR dysregulation: mechanisms of impaired skeletal muscle regeneration in SIV/HIV
酒精引起的 myomiR 失调:SIV/HIV 骨骼肌再生受损的机制
- 批准号:
9976400 - 财政年份:2016
- 资助金额:
$ 62.31万 - 项目类别:
Alcohol-induced myomiR dysregulation: mechanisms of impaired skeletal muscle regeneration in SIV/HIV
酒精引起的 myomiR 失调:SIV/HIV 骨骼肌再生受损的机制
- 批准号:
9310227 - 财政年份:2016
- 资助金额:
$ 62.31万 - 项目类别:
Role of the Angiogenic Chemokine, CXCL5, in Prostate Cancer
血管生成趋化因子 CXCL5 在前列腺癌中的作用
- 批准号:
8337160 - 财政年份:2012
- 资助金额:
$ 62.31万 - 项目类别:
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