Nipype: Dataflows for Reproducible Biomedical Research
Nipype: Dataflows for Reproducible Biomedical Research
批准号:
9053094
负责人:
Satrajit Sujit Ghosh
金额:
$71.25万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-01-15 至 2019-11-30
关键词:
AddressAdoptedAdoptionAlgorithmsArchitectureAutomationBackBig Data to KnowledgeBiomedical ResearchBrainBrain imagingCodeCommunitiesComplexComputer softwareCoupledDataData AnalysesData ProvenanceData SetData SourcesDatabasesDevelopmentDiagnosisDiagnosticDocumentationEcosystemEducationEducational workshopEnsureExposure toGalaxyGoalsImage AnalysisImageryImaging technologyLeadLibrariesLicensingMethodsOnline SystemsOutputPythonsReproducibilityResearchResearch InfrastructureResearch PersonnelResourcesServicesSoftware EngineeringSoftware ToolsSolidStagingSynapsesSystemTestingTrainingValidationVisualWorkbasebench to bedsidebioimagingclinical applicationcomputerized data processingcostdata accessdata managementdesignflexibilitygraphical user interfaceimprovedinteroperabilitynervous system disorderneuroimagingopen sourceprognosticprogramsrepositorysoftware developmentsymposiumtherapy developmenttoolusabilityweb appweb services
中文摘要
项目摘要
随着神经影像数据的大量增加,对可用的、自动化的、
强大的数据分析工具。Nipype是一个成熟的Python库,用于高效灵活地分析大"脑"
成像"数据。其可重用的工作流程可以将来自各种现有软件包的联合收割机算法组合在一起
以产生可重复的结果。该提案的目标是进一步增强可用性、功能性和
并扩大其传播。这将增加研究人员的使用,
临床医生,提高其对生物医学研究的影响,并解决其目前的许多局限性。制造商到使用
自动化工具可以减少错误,导致更快的生物医学发现,并促进从
长凳到床边从软件工程的角度来看,目标是提供一个设计良好的,跨平台的,
和可扩展的可编程计算解决方案,直观易用。
我们建议在目前广泛的功能集之上建立一个交互式和直观的基于Web的平台
与现有的数据库、软件和其他工作流服务进行互操作。结果将是一个
可通用、可伸缩、可扩展且经过测试的基础架构,可最大限度地减少复杂的编程接口
到随用随买的Web应用程序。Nipype仍将保留其可扩展的插件架构,
基于平台,允许继续包含新的软件包和算法,并在
多个平台。用户将能够为他们的数据使用最合适的分析策略。这
平台不仅允许继续使用熟悉的软件,还可以立即接触到最新的
数据分析软件工具。为了进行分析,用户将可以访问完整的出处,允许其他人
重现他们的脚步。我们将与NeuroVault和NeuroSynth互动,以提供无缝过渡
在数据、处理、共享和解释结果之间。最后,为了保持这种开放和合作的
努力,我们将通过实践研讨会和网络研讨会培训用户和开发人员,鼓励他们
扩大生态系统的优势,以实现高效和可重复的分析。
虽然该架构最初将部署在脑成像社区内,但我们将采用通用的
标准,以确保与更大的生物医学成像社区的互操作性。通过继续参与
用户社区和扩展生态系统的研究计算,该项目将降低障碍,
在大型数据集上进行简单有效的计算,目标是更快地开发治疗方案。
英文摘要
Project Summary
With the tremendous increase of neuroimaging data, there is a corresponding demand for usable, automated,
and robust data analysis tools. Nipype is a mature Python library for efficient and flexible analysis of Big “brain
imaging” Data. Its reusable workflows can combine algorithms from a diverse set of existing software packages
to generate reproducible results. The goal of this proposal is to further enhance the usability, functionality, and
interoperability of Nipype and to widen its dissemination. This will increase its use by researchers and
clinicians, boost its impact on biomedical research, and address many of its current limitations. Easier-to-use
automation tools can reduce errors, lead to faster biomedical discoveries, and facilitate the transition from
bench to bedside. From a software engineering standpoint, the goal is to offer a well-designed, cross-platform,
and extensible dataflow computing solution that is intuitive and easy to use.
We propose to build an interactive and intuitive web-based platform on top of the current extensive feature set
of Nipype that interoperates with existing databases, software, and other workflow services. The result will be a
generalizable, scalable, extensible, and tested infrastructure that minimizes complex programming interfaces
to easier-to-use web applications. Nipype will still retain its extensible plugin architecture behind this web-
based platform to allow continued inclusion of new software packages and algorithms, and execution on
multiple platforms. Users will be able to use the most appropriate analysis strategies for their data. This
platform will not only allow continued use of familiar software, but provide immediate exposure to the latest
software tools for data analyses. For analysis, users will have access to complete provenance allowing others to
reproduce their steps. We will interact with NeuroVault and NeuroSynth to provide a seamless transition
between data, processing, sharing, and interpreting results. Finally, to sustain such an open and collaborative
effort, we will train users and developers through hands-on workshops and webinars, encouraging them to take
advantage of an expanding ecosystem for efficient and reproducible analysis.
While the architecture will be initially deployed within the brain imaging community, we will adopt common
standards to ensure interoperability with the greater biomedical imaging community. By continuing to engage
the user community and extending the ecosystem for research computing, the project will lower the barrier for
easy and efficient computation on large datasets, with the goal of faster development of treatment options.
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