Center for Human Health and the Environment
Center for Human Health and the Environment
批准号:
9058068
负责人:
Keith emerson Linder
金额:
$6.06万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至
关键词:
Adverse effectsAffectAnimal HospitalsAnimal ModelAnimalsApplications GrantsArchivesBiologicalCellsCollaborationsComparative PathologyDevelopmentDiseaseDissectionEndocrine systemEnvironmentEnvironmental HealthEnvironmental Risk FactorEvaluationFosteringGenomicsGoldGrantHealthHumanJointsLasersMalignant NeoplasmsMedicineMethodsMissionModelingNeurologicOrganOrganismOutcomePathologicPathologistPathologyPathway interactionsPopulationProteomicsPublicationsReproductionResearchScientistSentinelSpeedSystemSystems BiologyTechniquesTechnologyTissuesToxic Environmental SubstancesToxic effectTrainingTranslational ResearchTranslationsVeterinary MedicineWorkabstractingbody systemcollegecompanion animalcomparativehealth science researchhuman diseasein vivo Modelinnovationmembermetabolomics
中文摘要
比较病理学核心
摘要
体内模型生物在一个系统生物学框架内运行,该框架集成了所有水平的生物学
组织-生物分子、途径、细胞、器官、生物体,并告知我们潜在的对人类不利的信息
健康结果。出于这个原因,动物模型仍然是研究高血压的影响的黄金标准。
环境毒物对发育、癌症、生殖、器官毒性、神经和内分泌的影响
系统-了解这些不利影响需要对受影响的细胞进行病理评估,并
器官。人类健康与环境中心(CHHE)的使命比较
病理学核心(CPC)是为CHHE成员提供病理学专业知识,以评估
不同动物模型中的环境因素。CPC病理学家和一个病理学家网络
专门的器官系统专业知识将为CHHE成员提供高级病理评估
项目并最大限度地提高病理学家与CHHE成员的合作,从而获得共同撰写的赠款
环境健康科学(EHS)的投稿和出版物。进一步加强车氏会员队伍建设
能力,CPC将与系统技术核心密切合作,利用激光捕获微型
从进展期动物模型皮损组织中分离特定细胞亚群的方法
生物分子评估-蛋白质组学、基因组学和代谢组学。CPC位于一个
国际公认的兽医学院,将成为CHHE成员
Access Companion动物疾病组织档案,比较医学中心和
翻译研究,并与大型陪护动物医院人群发展创新
人类环境卫生疾病的伴生动物模型与传统模型和
加快EHS研究的转化,以解决人类疾病。CPC病理技术和技术培训
组织评价方法将扩大CHHE的EHS动物模型研究能力。
英文摘要
COMPARATIVE PATHOLOGY CORE
ABSTRACT
In vivo model organisms operate in a systems biology framework integrating all levels of biological
organization - biomolecule, pathway, cell, organ, organism and inform us of potential adverse human
health outcomes. For this reason, animal models remain the gold standard for studying the effects of
environmental toxicants on development, cancer, reproduction, organ toxicity, neurological and endocrine
systems - understanding these adverse effects requires pathologic evaluation of the affected cells and
organs. The mission of the Center for Human Health and the Environment (CHHE) Comparative
Pathology Core (CPC) is to provide pathology expertise to CHHE members to assess the effects of
environmental factors in diverse animal models. CPC pathologists and a network of pathologists with
specialized organ system expertise will provide advanced pathology evaluation for CHHE member
projects and maximize pathologists collaborations with CHHE members leading to joint-authored grant
submissions and publications in environmental health science (EHS). To further enhance CHHE member
capabilities, the CPC will work closely with the Systems Technologies Core utilizing laser-capture micro-
dissection to isolate specific cellular subpopulations from lesional tissues of animal models for advanced
biomolecule assessments - proteomics, genomics and metabolomics. The CPC is located at an
internationally recognized College of Veterinary Medicine and will be a gateway for CHHE members to
access Companion Animal Diseased Tissue Archives, The Center for Comparative Medicine and
Translational Research, and a large companion animal hospital population to develop innovative
companion animal models of human environmental health diseases to compliment traditional models and
to speed translation of EHS research to solve human disease. CPC training in pathology techniques and
tissue assessment methods will expand EHS animal model research capability of the CHHE.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Comparative Pathology Core
-
批准号:10600025
-
项目类别:
-
资助金额:$6.48万
-
财政年份:2015
-
负责人:Keith emerson Linder
-
依托单位:
Comparative Pathology Core
-
批准号:10162597
-
项目类别:
-
资助金额:$6.48万
-
财政年份:2015
-
负责人:Keith emerson Linder
-
依托单位:
Center for Human Health and the Environment
-
批准号:9257409
-
项目类别:
-
资助金额:$6.06万
-
财政年份:--
-
负责人:Keith emerson Linder
-
依托单位:
Center for Human Health and the Environment
-
批准号:8841240
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项目类别:
-
资助金额:$6.01万
-
财政年份:--
-
负责人:Keith emerson Linder
-
依托单位:
Comparative Pathology Core
-
批准号:9911375
-
项目类别:
-
资助金额:$6.48万
-
财政年份:--
-
负责人:Keith emerson Linder
-
依托单位:
海外基金