Center for Human Health and the Environment

人类健康与环境中心

• 批准号: 9257409
• 负责人: Keith emerson Linder
• 金额: $ 6.06万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9257409
• 关键词: Adverse effects; Affect; Animal Diseases; Animal Hospitals; Animal Model; Applications Grants; Archives; Biological; Cells; Collaborations; Comparative Pathology; Development; Disease; Endocrine system; Environment; Environmental Health; Environmental Risk Factor; Evaluation; Fostering; Genomics; Gold; Grant; Health; Human; International; Joints; Lesion; Malignant Neoplasms; Medicine; Methods; Mission; Modeling; Neurologic; Organ; Organism; Outcome; Pathologic; Pathologist; Pathology; Pathway interactions; Population; Proteomics; Publications; Reproduction; Research; Scientist; Sentinel; Speed; System; Systems Biology; Techniques; Technology; Tissues; Toxic Environmental Substances; Toxic effect; Training; Translational Research; Translations; Veterinary Medicine; Work; animal tissue; body system; college; companion animal; comparative; human disease; in vivo Model; innovation; laser capture microdissection; member; metabolomics

COMPARATIVE PATHOLOGY CORE ABSTRACT In vivo model organisms operate in a systems biology framework integrating all levels of biological organization - biomolecule, pathway, cell, organ, organism and inform us of potential adverse human health outcomes. For this reason, animal models remain the gold standard for studying the effects of environmental toxicants on development, cancer, reproduction, organ toxicity, neurological and endocrine systems - understanding these adverse effects requires pathologic evaluation of the affected cells and organs. The mission of the Center for Human Health and the Environment (CHHE) Comparative Pathology Core (CPC) is to provide pathology expertise to CHHE members to assess the effects of environmental factors in diverse animal models. CPC pathologists and a network of pathologists with specialized organ system expertise will provide advanced pathology evaluation for CHHE member projects and maximize pathologists collaborations with CHHE members leading to joint-authored grant submissions and publications in environmental health science (EHS). To further enhance CHHE member capabilities, the CPC will work closely with the Systems Technologies Core utilizing laser-capture micro- dissection to isolate specific cellular subpopulations from lesional tissues of animal models for advanced biomolecule assessments - proteomics, genomics and metabolomics. The CPC is located at an internationally recognized College of Veterinary Medicine and will be a gateway for CHHE members to access Companion Animal Diseased Tissue Archives, The Center for Comparative Medicine and Translational Research, and a large companion animal hospital population to develop innovative companion animal models of human environmental health diseases to compliment traditional models and to speed translation of EHS research to solve human disease. CPC training in pathology techniques and tissue assessment methods will expand EHS animal model research capability of the CHHE.

比较病理学核心 摘要 体内模型生物在一个系统生物学框架内运行，该框架集成了所有级别的生物学 组织-生物分子、途径、细胞、器官、生物体，并告知我们潜在的对人类不利的信息 健康结果。出于这个原因，动物模型仍然是研究高血压的影响的黄金标准。 环境毒物对发育、癌症、生殖、器官毒性、神经和内分泌的影响 系统-了解这些不利影响需要对受影响的细胞进行病理评估，并 器官。人类健康与环境中心(CHHE)的使命比较 病理学核心(CPC)是为CHHE成员提供病理学专业知识，以评估 不同动物模型中的环境因素。CPC病理学家和一个病理学家网络 专门的器官系统专业知识将为CHHE成员提供高级病理评估 项目并最大限度地提高病理学家与CHHE成员的合作，从而获得共同撰写的赠款 环境健康科学(EHS)的投稿和出版物。进一步加强车氏会员队伍建设 能力，CPC将与系统技术核心密切合作，利用激光捕获微型 从进展期动物模型皮损组织中分离特定细胞亚群的方法 生物分子评估-蛋白质组学、基因组学和代谢组学。CPC位于一个 国际公认的兽医学院，将成为CHHE成员 Access Companion动物疾病组织档案，比较医学中心和 翻译研究，并与大型陪护动物医院人群发展创新 人类环境卫生疾病的伴生动物模型与传统模型和 加快EHS研究的转化，以解决人类疾病。CPC病理技术和技术培训 组织评价方法将扩大CHHE的EHS动物模型研究能力。