Center for Human Health and the Environment

人类健康与环境中心

• 批准号: 8841240
• 负责人: Keith emerson Linder
• 金额: $ 6.01万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8841240
• 关键词: Adverse effects; Affect; Animal Hospitals; Animal Model; Animals; Applications Grants; Archives; Biological; Cells; Collaborations; Comparative Pathology; Development; Disease; Dissection; Endocrine system; Environment; Environmental Health; Environmental Risk Factor; Evaluation; Fostering; Genomics; Gold; Grant; Health; Human; Joints; Lasers; Malignant Neoplasms; Medicine; Methods; Mission; Modeling; Neurologic; Organ; Organism; Outcome; Pathologic; Pathologist; Pathology; Pathway interactions; Population; Proteomics; Publications; Reproduction; Research; Scientist; Sentinel; Speed; System; Systems Biology; Techniques; Technology; Tissues; Toxic Environmental Substances; Toxic effect; Training; Translational Research; Translations; Veterinary Medicine; Work; abstracting; body system; college; companion animal; comparative; health science research; human disease; in vivo Model; innovation; member; metabolomics

COMPARATIVE PATHOLOGY CORE ABSTRACT In vivo model organisms operate in a systems biology framework integrating all levels of biological organization - biomolecule, pathway, cell, organ, organism and inform us of potential adverse human health outcomes. For this reason, animal models remain the gold standard for studying the effects of environmental toxicants on development, cancer, reproduction, organ toxicity, neurological and endocrine systems - understanding these adverse effects requires pathologic evaluation of the affected cells and organs. The mission of the Center for Human Health and the Environment (CHHE) Comparative Pathology Core (CPC) is to provide pathology expertise to CHHE members to assess the effects of environmental factors in diverse animal models. CPC pathologists and a network of pathologists with specialized organ system expertise will provide advanced pathology evaluation for CHHE member projects and maximize pathologists collaborations with CHHE members leading to joint-authored grant submissions and publications in environmental health science (EHS). To further enhance CHHE member capabilities, the CPC will work closely with the Systems Technologies Core utilizing laser-capture micro- dissection to isolate specific cellular subpopulations from lesional tissues of animal models for advanced biomolecule assessments - proteomics, genomics and metabolomics. The CPC is located at an internationally recognized College of Veterinary Medicine and will be a gateway for CHHE members to access Companion Animal Diseased Tissue Archives, The Center for Comparative Medicine and Translational Research, and a large companion animal hospital population to develop innovative companion animal models of human environmental health diseases to compliment traditional models and to speed translation of EHS research to solve human disease. CPC training in pathology techniques and tissue assessment methods will expand EHS animal model research capability of the CHHE.

比较病理学核心 摘要 体内模式生物在系统生物学框架中运行，该框架整合了所有生物学水平， 组织-生物分子，途径，细胞，器官，生物体，并告知我们潜在的不利人类 健康成果。出于这个原因，动物模型仍然是研究 环境毒物对发育、癌症、生殖、器官毒性、神经和内分泌 系统-了解这些不良反应需要对受影响的细胞进行病理学评估， 机关人类健康与环境中心的使命 病理学核心（CPC）是为CHHE成员提供病理学专业知识，以评估 不同动物模型中的环境因素。CPC病理学家和病理学家网络， 专业的器官系统专家将为CHHE成员提供先进的病理学评估 项目，并最大限度地提高病理学家与CHHE成员的合作，从而获得联合撰写的赠款 在环境健康科学（EHS）中提交和出版物。为了进一步提高CHHE成员 能力，CPC将与系统技术核心密切合作，利用激光捕获微 解剖以从用于晚期乳腺癌的动物模型的病变组织分离特定的细胞亚群 生物分子评估-蛋白质组学、基因组学和代谢组学。CPC位于 国际公认的兽医学院，将成为CHHE成员的门户， 访问伴侣动物组织档案，比较医学中心， 转化型研究，并为大型伴侣动物医院人群开发创新 人类环境健康疾病的伴侣动物模型，以补充传统模型， 加速EHS研究转化为解决人类疾病。CPC病理学技术培训， 组织评估方法将扩大CHHE的EHS动物模型研究能力。