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Comparative Pathology Core

比较病理学核心

基本信息

批准号：
10600025
负责人：
Keith emerson Linder
金额：
$ 6.48万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-04-20 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10600025
关键词：
Adverse effects Affect Animal Model Applications Grants Biological Canis familiaris Cavia Cells Collaborations Comparative Pathology Consultations Dedications Development Domestic Animals Endocrine system Environment Environmental Exposure Environmental Health Environmental Risk Factor Evaluation Family suidae Fishes Genetic Engineering Genetically Modified Animals Health Histology Human Laboratories Lesion Link Malignant Neoplasms Microtus Mission Molecular Molecular Analysis Mus Neurologic Organ Organism Oryctolagus cuniculus Oryziinae Outcome Pathologic Pathology Pathway interactions Publications Rattus Reproduction Scientist Sheep Systems Biology Techniques Technology Assessment Tissues Toxic Environmental Substances Toxic effect Training Vertebrates Xenopus Zebrafish cost health science research human disease in vivo in vivo Model member model organism technology platform

项目摘要

Vertebrate animal model use is essential to answer fundamental questions and elucidate the mechanisms in vivo through which environmental exposures may influence human disease and produce adverse human health outcomes. Diverse animal models, such as zebrafish, medaka fish, mouse, rat, rabbit, guinea pig, vole, xenopus, domestic animal (dogs, pigs, sheep, etc.) and others, along with their genetically engineered counterparts, represent powerful in vivo approaches to link molecular mechanisms to pathologic lesions (disrupted organ/tissue function) and toxic effects. Animal models remain the gold standard for studying these effects of environmental toxicants on development, cancer, reproduction, organ toxicity, and neurological and endocrine systems. These approaches are powerful because in vivo model organisms operate in a systems biology framework integrating all levels of biological organization - biomolecule, pathway, cell, tissue, organ, and organism - and inform us of potential adverse human health outcomes. Understanding these adverse effects requires expert pathologic evaluation of the affected tissue/organ/cells. To fill this need, the mission of the Comparative Pathology Core (CPC) is to provide CHHE member scientists dedicated access to cost-free pathology expertise to assess the effects of environmental factors in a diverse range of animal models.

脊椎动物模型的使用是必不可少的，以回答基本问题，阐明机制，环境暴露可通过其影响人类疾病并产生不利的人类健康健康成果。多种动物模型，如斑马鱼、青鳉鱼、小鼠、大鼠、兔、豚鼠、田鼠，爪蟾，家养动物（狗，猪，羊等）其他人，沿着他们的基因工程对应物，代表了将分子机制与病理损伤联系起来的强大体内方法（破坏器官/组织功能）和毒性作用。动物模型仍然是研究这些的黄金标准环境毒物对发育、癌症、生殖、器官毒性和神经和内分泌系统这些方法是强大的，因为体内模型生物体在一个系统中运行生物学框架整合了所有层次的生物组织-生物分子，途径，细胞，组织，器官，和有机体-并告知我们潜在的不利人类健康后果。了解这些不利因素需要对受影响的组织/器官/细胞进行专家病理学评估。为了满足这一需求，比较病理学核心（CPC）是为CHHE成员科学家提供免费的病理学专业知识，以评估各种动物模型中环境因素的影响。