Pilot Studies

摘要：初步研究 NIAAA的试点研究核心旨在“为中心提供灵活的开发和探索手段 新的研究活动或方向和独特的科学机会，有可能演变成 独立资助的研究项目”，以及促进和鼓励该领域的初级研究人员 酒精研究1。目前的试点核心提出了一个进行试点研究的方案， 有意义地扩展该中心的研究方法和议程，以及直接使NIH拨款 与我们目前关注的健康差距有关的应用。我们的计划还将涉及研究 和职业发展的需要，我们最有前途的新的和早期阶段的研究人员。我们的应用程序 基于1995-2000、2001-2005和2010-15年中心周期的3个非常成功的试点核心， 这一经验加强了我们提出的征求和选择项目以及管理研究的方法。 我们还利用我们长期（35年）的NIAAA T32酒精培训计划的经验， 包括培养和监督研究项目，以及广泛的职业发展，为博士后和 博士前实习生我们已确定5项试点研究可能纳入本轮研究，所有研究均 科学合理，与我们中心的整体研究计划相结合，并专注于健康 差距。然而，它们也具有高度创新性、多学科性、广泛的范围和潜力 影响;和高度多样化的问题，方法和人群。我们认为，这种多样性 方法和问题是至关重要的，以促进我们中心的研究充满活力和创新的计划， 我们的中心是这些研究的理想环境：我们在流行病学，政策， 和卫生服务，沿着我们丰富的差距基础研究人员（和统计部门）， 重要的支持。该核心将由Sarah Zemore博士指导，他是培训和MPI的联合主任， 我们中心的T32（与Lee Ann Kaskutas）以及中心的副主任。管理层将 由试点委员会提供支持，该委员会将包括所有中心经理和前任试点核心总监 卡斯库塔斯具体目标是：1）申请、选择和监测与 中心的研究计划;与我们中心对健康差异的关注一致;并且 高潜力导致独立的，NIH资助的研究赠款和高影响力的研究线; 2） 促进和鼓励初级（新的和早期阶段）调查员的职业发展，通过支持 指导其研究方向，提供具体的职业发展资源; 评估试点方案，必要时完善程序。

ABSTRACT: Pilot Studies NIAAA's Pilot Studies Core is intended to “provide the Center with a flexible means to develop and explore new research activities or directions and unique scientific opportunities that have the potential to evolve into independently-funded research projects,” as well as to promote and encourage junior investigators in the field of alcohol research1. The current Pilots Core proposes a program for conducting pilot studies that would meaningfully extend the Center's research methods and agenda as well as directly enable NIH grant applications relevant to our current focus on health disparities. Our program would also address the research and career development needs of our most promising new and early stage investigators. Our application builds on 3 highly successful prior Pilots Cores from Center cycles 1995-2000, 2001-2005, and 2010-15, and this experience undergirds our proposed methods for soliciting and selecting projects and managing studies. We also draw on our experience with our longstanding (35-year) NIAAA T32 alcohol training program, which involves cultivation and oversight of research projects, and career development broadly, for post-doctoral and pre-doctoral trainees. We have identified 5 pilot studies for potential inclusion in the current round, and all are scientifically sound and well-integrated with our Center's overall program of research and focus on health disparities. Nevertheless, they are also highly innovative; multidisciplinary; broad in scope and potential impact; and highly diverse in questions, methods, and populations. We believe that this diversity of approaches and questions is critical to fostering a vibrant and innovative program of research at our Center, and that our Center is the ideal environment for these studies: Our strong grounding in epidemiology, policy, and health services, along with our rich base of disparities researchers (and statistical department), lend important support. This Core will be directed by Dr. Sarah Zemore, who is Co-Director of Training and MPI of the T32 at our Center (with Lee Ann Kaskutas) as well as Associate Director of the Center. Management will be supported by a Pilots Committee, which will include all Center Managers and prior Pilots Core Director Kaskutas. Specific Aims are to 1) requisition, select, and monitor pilot studies that are well-integrated with the Center's program of research; that are consistent with our Center's focus on health disparities; and that have high potential to lead to independent, NIH-funded research grants and high-impact lines of research; 2) promote and encourage junior (new and early stage) investigators in their career development via supporting and guiding their research lines and providing specific career development resources; and 3) continually evaluate the pilot program and refine procedures as necessary.