Pilot Studies

摘要：试点研究 NIAAA的试点研究核心旨在为中心提供开发和探索的灵活手段 新的研究活动或方向和独特的科学机会，有可能演变成 独立资助的研究项目“，以及促进和鼓励该领域的初级调查人员 酒精研究1。目前的飞行员核心提出了一项进行试点研究的计划，该计划将 有意义地扩展中心的研究方法和议程，并直接支持NIH拨款 与我们目前对健康差距的关注相关的应用。我们的计划也将涉及研究 以及我们最有前途的新的和早期的调查人员的职业发展需求。我们的应用程序 构建在1995-2000、2001-2005和2010-15三个中心周期中非常成功的之前的Pilot核心上，以及 这一经验支持了我们提出的征集和选择项目以及管理研究的方法。 我们还借鉴了我们长期(35年)的NIAAA T32酒精培训计划的经验，其中 包括培养和监督博士后和博士后研究项目，以及广泛的职业发展 博士前实习生。我们已经确定了5项可能纳入本轮研究的试点研究，所有这些研究都是 科学合理，并与我们中心研究和关注健康的总体计划很好地结合在一起 差距。然而，它们也是高度创新的；多学科的；范围和潜力广泛的 影响；在问题、方法和人群方面高度多样化。我们相信，这种多样性 方法和问题对于培养我们中心充满活力和创新的研究项目至关重要， 我们的中心是进行这些研究的理想环境：我们在流行病学、政策、 和卫生服务，以及我们丰富的差距研究人员(和统计部门)，借出 重要的支持。这一核心将由萨拉·泽莫尔博士指导，她是 我们中心的T32(与Lee Ann Kaskutas)以及中心副主任。管理层将 由飞行员委员会提供支持，该委员会将包括所有中心经理和之前的飞行员核心主任 卡斯库塔斯。具体目标是1)征用、选择和监测与 中心的研究计划；与我们中心对健康差距的关注一致；以及 高潜力导致独立的、NIH资助的研究资助和高影响的研究领域；2) 通过支持促进和鼓励初级(新的和早期)调查人员的职业发展 指导他们的研究路线，提供具体的职业发展资源；3)继续 评估试点计划，并根据需要改进程序。

ABSTRACT: Pilot Studies NIAAA's Pilot Studies Core is intended to “provide the Center with a flexible means to develop and explore new research activities or directions and unique scientific opportunities that have the potential to evolve into independently-funded research projects,” as well as to promote and encourage junior investigators in the field of alcohol research1. The current Pilots Core proposes a program for conducting pilot studies that would meaningfully extend the Center's research methods and agenda as well as directly enable NIH grant applications relevant to our current focus on health disparities. Our program would also address the research and career development needs of our most promising new and early stage investigators. Our application builds on 3 highly successful prior Pilots Cores from Center cycles 1995-2000, 2001-2005, and 2010-15, and this experience undergirds our proposed methods for soliciting and selecting projects and managing studies. We also draw on our experience with our longstanding (35-year) NIAAA T32 alcohol training program, which involves cultivation and oversight of research projects, and career development broadly, for post-doctoral and pre-doctoral trainees. We have identified 5 pilot studies for potential inclusion in the current round, and all are scientifically sound and well-integrated with our Center's overall program of research and focus on health disparities. Nevertheless, they are also highly innovative; multidisciplinary; broad in scope and potential impact; and highly diverse in questions, methods, and populations. We believe that this diversity of approaches and questions is critical to fostering a vibrant and innovative program of research at our Center, and that our Center is the ideal environment for these studies: Our strong grounding in epidemiology, policy, and health services, along with our rich base of disparities researchers (and statistical department), lend important support. This Core will be directed by Dr. Sarah Zemore, who is Co-Director of Training and MPI of the T32 at our Center (with Lee Ann Kaskutas) as well as Associate Director of the Center. Management will be supported by a Pilots Committee, which will include all Center Managers and prior Pilots Core Director Kaskutas. Specific Aims are to 1) requisition, select, and monitor pilot studies that are well-integrated with the Center's program of research; that are consistent with our Center's focus on health disparities; and that have high potential to lead to independent, NIH-funded research grants and high-impact lines of research; 2) promote and encourage junior (new and early stage) investigators in their career development via supporting and guiding their research lines and providing specific career development resources; and 3) continually evaluate the pilot program and refine procedures as necessary.