Prenatal exposure to phthalates and neurodevelopment in children

产前接触邻苯二甲酸盐与儿童神经发育

• 批准号: 9168535
• 负责人: SHARON K. SAGIV
• 金额: $ 7.85万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9168535
• 关键词: 7 year old; Accounting; Adolescence; Age; Animals; Anxiety; Attention; Behavior; Behavioral; Biological; Birth; Brain; Breathing; Chemicals; Child; Childhood; Chronic; Cognition; Cognitive; Comprehension; Consumer Product Safety; Cosmetics; Data; Data Quality; Dermal; Development; Diet; Endocrine Disruptors; Environment; Epidemiologic Studies; Exposure to; Fetus; Food Packaging; Health; Homeostasis; Hour; Human; Hyperactive behavior; Literature; Measures; Mediating; Medical Device; Memory impairment; Methods; Mothers; Nature; Nervous system structure; Neurosecretory Systems; Neurotoxins; Outcome; Parents; Pathway interactions; Performance; Placenta; Plasticizers; Population; Pregnancy; Public Health; Recruitment Activity; Reporting; Research; Rodent; Salinum; Sample Size; Sampling; Short-Term Memory; Statistical Models; Testing; Thyroid Hormones; Time; Toxic effect; Toy; Urine; Work; absorption; age group; androgenic; base; building materials; chemical group; cognitive development; cohort; design; early adolescence; early life exposure; executive function; exposed human population; externalizing behavior; flexibility; hazard; memory process; neurodevelopment; neuropsychological; offspring; personal care products; phthalates; policy implication; prenatal; prenatal exposure; processing speed; resilience; social cognition; teacher; urinary

ABSTRACT Phthalates are synthetic chemicals used in personal care products and in flexible plastic products. Along with their metabolites, phthalates are rapidly excreted in humans with half-lives of 5-24 hours. Exposure to phthalates is ubiquitous because of their widespread use and their ability to leach easily into the environment. Phthalates are endocrine-disrupting chemicals that may interfere with neuroendocrine pathways involved in neurodevelopment, including anti-androgenic activity and thyroid hormone homeostasis. The prenatal period is a particularly sensitive target for phthalate exposure due to rapid brain development. Previous studies of phthalates and neurodevelopment are limited by small sample size, cross-sectional design, and limited data on neurodevelopment. The primary objective of the proposed research is to investigate the association of prenatal exposure to phthalates with cognitive and behavioral development in childhood and adolescence. We will examine these relationships in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a large, well-characterized longitudinal pre-birth cohort of mothers recruited 1999-2000 during pregnancy and their offspring. We will analyze existing data on maternal phthalate levels, measured twice during pregnancy (~13 and 26 weeks), in relation to the cohort's extensive data on neurodevelopment measured from age 7 years until adolescence for 336 children with exposure and outcome data. We will examine associations with the following outcomes: (1) general cognition, (2) executive function, (3) attention problems, externalizing behaviors and internalizing behaviors, and (4) social cognition. This study will take advantage of the CHAMACOS cohort's longitudinal data collected on teacher- and parent-rated scales as well as objective, performance-based tests. Additionally, this will be the first study to examine associations of phthalates with neurodevelopmental measures in adolescence, a critical time for manifestations of early life exposure effects. Results of this study, which will further our understanding of the long-term impact of early-life exposure to phthalates on neurodevelopment, have important policy implications given that widespread exposure to these chemicals in personal care products is modifiable and alternatives may be available during sensitive time windows, such as pregnancy.

摘要 邻苯二甲酸酯是用于个人护理产品和柔性塑料产品的合成化学品。沿着 其代谢物邻苯二甲酸酯在人体内迅速排泄，半衰期为5-24小时。暴露于 邻苯二甲酸酯是普遍存在的，因为它们的广泛使用和它们容易浸出到环境中的能力。 邻苯二甲酸酯是内分泌干扰化学品，可能会干扰神经内分泌途径， 神经发育，包括抗雄激素活性和甲状腺激素稳态。产前期是 由于大脑的快速发育，邻苯二甲酸酯暴露是一个特别敏感的目标。以往的研究 邻苯二甲酸酯和神经发育受到样本量小、横断面设计和以下方面数据有限的限制： 神经发育这项研究的主要目的是调查产前检查与妊娠结局的关系。 邻苯二甲酸酯对儿童和青少年的认知和行为发育的影响。我们将 在萨利纳斯母亲和儿童健康评估中心检查这些关系 （CHAMACOS），一个大型的，特征良好的纵向出生前队列的母亲招募1999-2000年期间， 怀孕和他们的后代。我们将分析关于母亲邻苯二甲酸酯水平的现有数据， 妊娠期间（~13和26周），与队列的广泛神经发育数据相关 从7岁到青春期测量336名儿童的暴露和结果数据。我们将 检查与以下结果的关联：（1）一般认知，（2）执行功能，（3）注意力 问题、外化行为和内化行为;（4）社会认知。这项研究将采取 CHAMACOS队列在教师和家长评分量表上收集的纵向数据的优势 作为客观的基于表现的测试此外，这将是第一项研究，以检查协会 邻苯二甲酸酯与青春期神经发育指标的关系，青春期是早期生命表现的关键时期 暴露效应这项研究的结果，这将进一步我们了解的长期影响的早期生活， 暴露于邻苯二甲酸酯对神经发育的影响，具有重要的政策意义， 在个人护理产品中接触这些化学品是可以改变的， 敏感的时间窗口，如怀孕。