PRENATAL EXPOSURE TO METHYLMERCURY AND CHILDHOOD BEHAVIOR

产前接触甲基汞和儿童行为

• 批准号: 7531571
• 负责人: SHARON K. SAGIV
• 金额: $ 8.15万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-13 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7531571
• 关键词: Attention; Attention deficit hyperactivity disorder; Behavior; Behavior assessment; Behavioral; Biological Markers; Birth; Brain; Child; Childhood; Cognitive; Consensus; Consumption; Data; Disease regression; Evaluation; Exposure to; Faeroe Islands; Fishes; Hair; Health Benefit; Infant; Intelligence; Island; Literature; Massachusetts; Measurement; Measures; Methylmercury Compounds; Mothers; Neonatal; Outcome; Parents; Polychlorinated Biphenyls; Postpartum Period; Prospective Studies; Public Health; Range; Rate; Reporting; Research; Research Personnel; School-Age Population; Seminal; Sex Characteristics; Seychelles; Source; System; Uncertainty; cohort; day; hazard; neurobehavior; neurobehavioral; neurodevelopment; performance tests; prenatal; prenatal exposure; prospective; superfund site; teacher

DESCRIPTION (provided by investigator): There is uncertainty about the effect of low-level methylmercury (MeHg) exposure on neurodevelopment. Two seminal studies conducted in the Faroe Islands and the Seychelles Islands of prenatal MeHg exposure report inconsistent conclusions with respect to cognitive and behavioral outcomes. The primary aims of the proposed research are to investigate: 1) the association between prenatal MeHg and attention-associated behaviors among infants using the Neonatal Behavioral Assessment Scale (NBAS); and 2) the association between MeHg and behaviors associated with Attention Deficit Hyperactivity Disorder (ADHD) among school-aged children (median=8 years) using the Conners' Rating Scale for Teachers (CRS-T), the Neurobehavioral Evaluation System 2 (NES2) Continuous Performance Test (CPT), and components of the Wechsler Intelligence Scale for Children-Third Edition (WISC-III). We will also investigate a potential synergistic effect of MeHg and polychlorinated biphenyls (PCBs) on behavior and evaluate gender differences for the MeHg and behavior associations. Finally, we will assess the potential confounding effect of fish consumption on the association between MeHg and behavior. The study will be conducted among a birth cohort of 788 infants born between 1993 and 1998 to mothers residing adjacent to a PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts. MeHg was measured in maternal hair collected at approximately 10 days postpartum. Associations with behavioral outcomes will be estimated with multivariable regression, controlling for a wide range of covariates. Results of this study will build upon the literature on the neurodevelopmental effects of MeHg. This is critical to arriving at consensus in informing the public about the potential hazard of prenatal MeHg exposure, given that the primary source of exposure is fish consumption, which is associated with substantial health benefits, including benefits to neurodevelopment. PROJECT HEALTH RELEVANCE The association between prenatal methylmercury (MeHg) and neurodevelopment is not well understood. This study will be an important contribution to the literature necessary for informing the public about the potential hazard associated with prenatal MeHg exposure, given the apparent benefit of fish consumption on the developing brain.

描述（由研究人员提供）：关于低水平甲基汞（MEHG）暴露对神经发育的影响存在不确定性。在法罗群岛和塞舌尔群岛进行的两项开创性研究报告了关于认知和行为结果的结论不一致。拟议研究的主要目的是研究：1）使用新生儿行为评估量表（NBAS），婴儿产前MEHG与注意相关行为之间的关联； 2）使用Conners对教师的评分量表（CRS-T），神经行为评估系统2（NES2）连续绩效测试（CPT）（CPT），以及Wechsler Intellionce Quaiciss for Wechsler Intelligence-Specie（WISC），MEHG与注意力缺陷多动障碍（ADHD）之间的关联与注意力缺陷多动障碍（ADHD）相关（中位数= 8年），以及Wechsler Intelligence Intelligence Spare（Wechsler Intelligence Spare）（Wechsler Intellionce score（WISC）的组成（WISC）。我们还将研究MEHG和多氯联苯（PCB）对行为的潜在协同作用，并评估MEHG和行为关联的性别差异。最后，我们将评估鱼类消耗对MEHG与行为之间关联的潜在混杂作用。这项研究将在1993年至1998年间出生的788名婴儿的出生队列中，向马萨诸塞州新贝德福德的一个受PCB污染的港口和超级基金地点附近的母亲进行。 MEHG是在产后大约10天收集的孕妇头发中测量的。与行为结果的关联将通过多变量回归进行估算，从而控制了广泛的协变量。这项研究的结果将基于有关MEHG神经发育影响的文献。这对于达成共识在向公众通报产前MEHG暴露的潜在危害的共识至关重要，因为主要的接触来源是鱼类消耗，这与可观的健康益处有关，包括对神经发育的益处。项目健康相关性是尚不清楚产前甲基汞（MEHG）与神经发育之间的关联。鉴于鱼类消费在发育中的大脑中显然有益，这项研究将是向公众通报与产前MEHG暴露相关的潜在危害所必需的文献的重要贡献。