PRENATAL EXPOSURE TO MANGANESE AND ADHD-LIKE BEHAVIORS IN CHILDHOOD

产前接触锰和儿童时期出现多动症样行为

• 批准号: 7631074
• 负责人: SHARON K. SAGIV
• 金额: $ 10.5万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7631074
• 关键词: Archives; Attention; Attention deficit hyperactivity disorder; Behavior; Behavior Disorders; Behavior assessment; Birth; Blood specimen; Characteristics; Child; Child Development; Childhood; Development; Diagnosis; Environmental Risk Factor; Etiology; Evaluation; Exposure to; General Population; Impulsivity; Incidence; Infant; Intelligence; Joints; Lead; Life; Manganese; Massachusetts; Measures; Medical Records; Metals; Mothers; Neonatal; Neurotoxins; Nutrient; Parents; Pharmaceutical Preparations; Play; Polychlorinated Biphenyls; Population; Prospective Studies; Psychometrics; Reporting; Research; Research Personnel; Risk; Risk Factors; Role; School-Age Population; System; Testing; Umbilical Cord Blood; Wechsler Scales; cohort; inattention; insight; neurobehavior; neurobehavioral; performance tests; postnatal; prenatal; prenatal exposure; public health relevance; superfund site; synergism; teacher

DESCRIPTION (provided by investigator): The etiology of Attention Deficit Hyperactivity Disorder (ADHD) is poorly understood and identification of modifiable environmental risk factors is important for reducing its incidence. Manganese (Mn) is both an essential nutrient and, at high levels, a potential neurotoxicant to which the general population is commonly exposed. The primary aim of the proposed research is to investigate the association of prenatal Mn with behaviors associated with ADHD among infants using the Neonatal Behavioral Assessment Scale (NBAS), and among school-aged children (median=8 years) using three assessments: (1) clinically diagnosed ADHD; (2) behaviors associated with ADHD assessed with the Conners' Rating Scale for Teachers: and (3) behaviors associated with ADHD measured with formal psychometric tests, including the Neurobehavioral Evaluation System 2 Continuous Performance Test, and components of the Wechsler Intelligence Scale for Children-Third Edition. We will also investigate potential synergism between Mn and lead (Pb) on risk for ADHD. The study will be conducted among a birth cohort of 788 infants born between 1993 and 1998 to mothers residing adjacent to a metal- and PCB-contaminated harbor and Superfund site in New Bedford, Massachusetts. Mn is measured in archived cord blood samples. Associations will be estimated with multivariable regression, controlling for a wide range of covariates. The proposed study is the largest U.S. study to date to assess the effect of prenatal Mn on subsequent neurobehavior in children and will benefit from the use of a well characterized population whose development has been assessed longitudinally since birth and for whom a wealth of information on risk factors for adverse child development is available. Results will provide important insight into the role of Mn as a potentially remediable risk factor for common behavioral disorders such as ADHD. PUBLIC HEALTH RELEVANCE: Manganese (Mn) is a naturally occurring metal which is both an essential nutrient, and potential neurotoxicant. This study will investigate the association between prenatal Mn and childhood neurobehavioral development, particularly ADHD-related behavior. Our findings will provide important insight into the role of Mn as potentially remediable risk factor for this increasingly common and costly behavioral disorder of childhood.

描述（由研究者提供）：注意力缺陷多动症（ADHD）的病因尚不清楚，对可修改的环境风险因素的识别对于降低其发病率很重要。锰（MN）既是必不可少的营养素，而且在高水平上，通常会暴露出普通人群的潜在神经毒性。拟议研究的主要目的是研究使用新生儿行为评估量表（NBAS）（NBA）以及使用三种评估的学龄儿童（中位数= 8年）之间的婴儿与ADHD相关的行为的关联：（1）临床诊断为ADHD； （2）与ADHD相关的行为与Conners对教师的评级量表进行了评估：（3）与正式心理测验测量的ADHD相关的行为，包括Neurobehavioral评估系统2连续绩效测试以及Wechsler Intellionce量表的儿童三角版本的wechsler智能量表。我们还将研究MN和铅（PB）之间的潜在协同作用，以了解多动症的风险。这项研究将在1993年至1998年间出生的788名婴儿的出生队列中，靠近马萨诸塞州新贝德福德的金属和PCB污染的港口和超级基金遗址。 MN在存档的脐带血样品中测量。关联将通过多变量回归进行估计，以控制广泛的协变量。拟议的研究是迄今为止最大的美国研究，旨在评估产前MN对后续儿童神经行为的影响，并将受益于使用良好的人群的使用，该人群自出生以来就已经纵向评估了其发展，并且为他们提供了有关不良儿童发展风险因素的大量信息。结果将为MN作为常见行为障碍（例如ADHD）的潜在补救危险因素的作用提供重要的见解。公共卫生相关性：锰（MN）是一种天然存在的金属，既是必不可少的营养素，又是潜在的神经毒性。这项研究将研究产前MN与儿童神经行为发展之间的关联，尤其是与ADHD相关的行为。我们的发现将为MN作为这种日益普遍且昂贵的童年行为障碍的潜在补救危险因素的作用提供重要的见解。