Prenatal exposure to polyfluoroalkyl chemicals (PFCs) and child growth and develo

产前接触多氟烷基化学品 (PFC) 与儿童生长发育

• 批准号: 8535758
• 负责人: SHARON K. SAGIV
• 金额: $ 58.97万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-23 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8535758
• 关键词: 3 year old; 7 year old; Accounting; Acids; Address; Adverse effects; Affect; Age; Alkanesulfonates; Animals; Antibodies; Archives; Attention deficit hyperactivity disorder; Behavior; Behavioral; Birth; Blood Pressure; Blood specimen; Carpet; Chemical Exposure; Chemicals; Child; Child Development; Childhood; Cholesterol; Cognition; Data; Development; Dose; Enhancing Antibodies; Environment; Epidemiologic Studies; Exposure to; Fetus; First Pregnancy Trimester; Food Packaging; Furniture; Growth; Growth and Development function; Head circumference; Health; Height; High Density Lipoprotein Cholesterol; Human; Hypertension; Industrial Product; Infant; Insulin; Insulin Resistance; Intelligence; Investigation; Iodide Peroxidase; LDL Cholesterol Lipoproteins; Language; Lipids; Literature; Maternal Physiology; Measurement; Measures; Mediating; Metabolic; Modeling; Modification; Mothers; Neonatal; Newborn Infant; Obesity; Outcome; Pathway interactions; Placenta; Plasma; Population; Pregnancy; Public Health; Recruitment Activity; Research; Research Project Grants; Resistance; Risk Factors; Role; Sampling; Serum; Skinfold Thickness; Staining method; Stains; Surface; Textiles; Thyroid Function Tests; Thyroid Hormones; Thyrotropin; Thyroxine; Weight; Whole Blood; Work; adiponectin; chemical property; cohort; consumer product; cost effective; early childhood; executive function; fasting glucose; fetal; hazard; human data; human tissue; indexing; infancy; interest; neurodevelopment; neurotoxic; offspring; perfluorohexane; perfluorooctane sulfonate; postnatal; pregnant; prenatal; prenatal exposure; surfactant; toxicant; uptake; visual memory; visual motor; waist circumference

DESCRIPTION (provided by applicant): PFCs are synthetic chemicals used as surfactants and in surface protection, including stain-resistant products (e.g., carpets and fabrics), nonstick coatings, and food packaging. PFCs are ubiquitous and persistent in the environment and in human tissue. Though present in the environment for decades, PFCs are relatively new compounds of interest with respect to health outcomes and there is mounting evidence from animal and human studies suggesting that they may be developmental toxicants. The primary aim of the proposed research is to investigate the association of prenatal PFC exposure with growth and development in children. We will measure levels of four perfluorinated compounds - perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA) - in prenatal maternal plasma collected in early gestation and estimate associations with fetal and infant somatic growth, childhood adiposity and metabolic outcomes such as serum cholesterol and insulin resistance, and neurodevelopment, including cognition and behavior. We will examine associations of PFCs with prenatal maternal and neonatal thyroid hormone levels and explore thyroid function as an underlying pathway for PFC-related associations with growth and neurodevelopment. We will also measure postnatal PFCs in offspring at age 7 to explore their contribution to these outcomes independent of prenatal exposure. We will investigate these aims in Project Viva, a large, well-characterized longitudinal pre-birth cohort of mothers recruited 1999-2002 during pregnancy (approximately 1,700 have archived early pregnancy plasma samples available for PFC analysis) and their offspring (approximately 610 have archived postnatal blood samples available for PFC analysis) followed from birth through age 7 years. We will estimate associations using multivariable regression, controlling for a wide range of covariates. This will be the largest study to date to assess the effect of prenatal PFCs on childhood growth and development the first study to account for prenatal and postnatal PFCs. This highly cost-effective investigation will benefit from the use of a well-characterized population assessed longitudinally since early pregnancy for whom a wealth of information on risk factors for adverse child development has already been collected. Recruitment of pregnant mothers during 1999-2002 coincides with the period of peak PFC emissions, enhancing our power to detect exposure effects. Results will further our understanding of the impact of prenatal and postnatal exposure to PFCs on growth and development during the prenatal and early childhood period. This is a major public health concern given the ubiquity and persistence of these chemicals in the environment and in humans and their potential role as developmental toxicants.

描述（由申请人提供）：PFC 是用作表面活性剂和表面保护的合成化学品，包括防污产品（例如地毯和织物）、不粘产品 涂料和食品包装。 PFC 在环境和人体组织中普遍存在且持久存在。尽管全氟化碳在环境中存在了数十年，但它对于健康结果来说是相对较新的化合物，并且越来越多的动物和人类研究证据表明它们可能是发育毒物。拟议研究的主要目的是调查产前 PFC 暴露与儿童生长发育的关系。我们将测量妊娠早期收集的产前母体血浆中四种全氟化合物 - 全氟辛酸 (PFOA)、全氟辛烷磺酸 (PFOS)、全氟己烷磺酸 (PFHxS) 和全氟壬酸 (PFNA) 的水平，并估计与胎儿和婴儿体细胞生长的关系。 儿童肥胖和代谢结果，例如血清胆固醇和胰岛素抵抗，以及神经发育，包括认知和行为。我们将研究 PFC 与产前母亲和新生儿甲状腺激素水平的关系，并探索甲状腺功能作为 PFC 与生长和神经发育相关关系的潜在途径。我们还将测量 7 岁时后代的产后 PFC，以探讨其对这些结果的贡献，而与产前暴露无关。我们将在 Viva 项目中研究这些目标，该项目是 1999 年至 2002 年在怀孕期间招募的母亲（约 1,700 名已存档可用于 PFC 分析的早孕血浆样本）及其后代（约 610 名已存档可用于 PFC 分析的产后血液样本）的大型、特征明确的产前纵向队列，跟踪从出生到 7 岁的情况。我们将使用多变量回归来估计关联，控制广泛的协变量。这将是迄今为止最大规模的评估产前 PFC 对儿童生长发育影响的研究，也是第一项考虑产前和产后 PFC 的研究。这项极具成本效益的调查将受益于使用自怀孕早期以来纵向评估的特征明确的人群，已经收集了有关儿童发育不良风险因素的大量信息。 1999-2002 年期间对怀孕母亲的招募恰逢 PFC 排放高峰期，增强了我们检测暴露影响的能力。结果将进一步了解产前和产后接触全氟化碳对产前和儿童早期生长发育的影响。鉴于这些化学物质在环境和人类中的普遍存在和持久性以及它们作为发育毒物的潜在作用，这是一个重大的公共卫生问题。