Metabolomics and Type 2 Diabetes in a Cohort of Older Puerto Ricans

波多黎各老年群体的代谢组学和 2 型糖尿病

• 批准号: 9178206
• 负责人: Shilpa Nandana Bhupathiraju
• 金额: $ 14.95万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-14 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9178206
• 关键词: Acculturation; Acids; Address; Adult; Advisory Committees; Affect; Amino Acids; Aminoisobutyric Acids; Area; Aromatic Amino Acids; Betaine; Beverages; Biological; Biological Markers; Boston; Case-Control Studies; Cereals; Chemicals; Choline; Chronic Disease; Coffee; Cohort Studies; Complex; Data; Data Set; Development; Diabetes Mellitus; Diet; Dietary Factors; Dietary Practices; Disease; Educational workshop; Ensure; Environment; Epidemic; Epidemiologic Studies; Epidemiologist; Epidemiology; Fiber; Functional disorder; Genomics; Glutamates; Glutamine; Health; High Prevalence; Hispanics; Human; Hypertension; Inflammation; Institution; Interdisciplinary Study; K-Series Research Career Programs; Levocarnitine; Life; Life Style; Lipids; Measures; Meat; Medical Research; Mentors; Metabolic; Metabolic syndrome; Mexican Americans; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Organism; Pathway interactions; Phenotype; Plasma; Play; Population; Postdoctoral Fellow; Prevalence; Prevention strategy; Preventive Intervention; Productivity; Proteomics; Public Health; Public Health Schools; Puerto Rican; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Sampling; Schools; Secondary to; Source; Stress; System; Technology; Testing; Training; Work; cardiometabolic risk; career; cohort; design; diabetes risk; experience; gut microbiota; health disparity; high risk; high throughput technology; laboratory experience; meetings; metabolic profile; metabolomics; modifiable risk; novel; novel marker; nutrition; nutritional epidemiology; population based; prevent; programs; prospective; skills; symposium; tool; transcriptomics; trimethyloxamine; urea cycle

PROJECT SUMMARY This 4-year K01 career development award was designed to provide the necessary resources and training to the candidate, Dr. Shilpa N Bhupathiraju, to launch an independent research career in the field of nutrition and chronic disease epidemiology. The training plan includes a mixture of didactic course work, hands-on laboratory training, metabolomics workshops, seminars, advisory committee meetings, career enrichment programs, and attendance at national conferences. It is intended to provide Dr. Bhupathiraju with the necessary skill set in the emerging fields of metabolomics and systems epidemiology. Dr. Bhupathiraju is a highly motivated and capable young researcher with an established record of research productivity in the area of dietary and lifestyle determinants of chronic diseases. However, in order to achieve research independence, she will need to master novel analytic tools in nutritional epidemiology such as systems epidemiology and metabolomics. The proposed project will be implemented at the Harvard T.H. Chan School of Public Health. The school is adjacent to a wide range of research and medical institutions giving Dr. Bhupathiraju access to an enormous range and depth of scientific expertise, resources, and opportunities to advance her career and establish research independence. The proposed project is unique and timely as it is the first ever to evaluate novel and unexplored metabolic biomarkers of type 2 diabetes (T2D) in a group of older Puerto Ricans. Among all Hispanic sub-groups, Puerto Ricans experience the poorest health with excessive prevalence of T2D, metabolic syndrome, hypertension, and obesity. They have unique dietary patterns that may contribute to T2D risk. Stored baseline samples from the Boston Puerto Rican Health Study will be used to measure promising metabolites related to T2D risk, including gut microbiota metabolites, urea cycle metabolites, 2-aminoadipic acid, 2-hydroxybutanoic acid, branched chain and aromatic amino acids, and β-aminoisobutyric acid in an efficient case-control study design of 120 prevalent T2D cases and 120 matched controls. By taking advantage of already measured cardiometabolic biomarkers at baseline and 2-years, the project will also evaluate the cross-sectional and prospective associations between candidate metabolites and intermediate markers of T2D. Secondary to these aims, the candidate will also 1) identify pathways and signatures associated with T2D, and 2) examine dietary sources of key metabolites. The Boston Puerto Rican Health Study is well-suited to examine these research questions as it has stored biospecimens and well-validated measures of diet, lifestyle, and ethnic-specific variables such as acculturation and perceived stress. Findings from the proposed research may help identify novel biomarkers and prevention strategies for T2D. The world-class mentoring team who are leaders in their respective fields together with the rich scientific environment and resources will ensure the successful and seamless transition of Dr. Bhupathiraju into an independent investigator in nutrition, metabolomics, and chronic disease epidemiology.

项目总结 这项为期4年的K01职业发展奖旨在提供必要的资源和培训，以 候选人希尔帕·N·布帕特里拉朱博士将开始在营养和营养领域的独立研究生涯 慢性病流行病学。培训计划包括授课课程作业、实际操作 实验室培训、代谢组学研讨会、研讨会、咨询委员会会议、职业充实 计划，以及出席国家会议。它的目的是为布帕特里拉朱博士提供 新陈代谢组学和系统流行病学新兴领域的必备技能。布帕提拉朱博士是一名 积极进取、有能力的年轻研究人员，在该领域具有既定的研究效率记录 饮食和生活方式是慢性病的决定因素。但是，为了实现研究的独立性， 她将需要掌握营养流行病学的新分析工具，如系统流行病学和 代谢组学。拟议的项目将在哈佛大学陈德熙公共卫生学院实施。 这所学校毗邻一系列的研究和医疗机构，使布帕提拉朱博士能够获得 广泛而深入的科学专业知识、资源和机会，以推动她的职业生涯和 建立研究自主性。拟议的项目是独特的和及时的，因为它是有史以来第一次进行评估 一组波多黎各老年人2型糖尿病(T2D)的新的和未被探索的代谢生物标志物。其中 所有拉美裔亚群中，波多黎各人的健康状况最差，T2D的患病率过高， 代谢综合征、高血压和肥胖症。他们有独特的饮食模式，这可能有助于T2D 风险。波士顿波多黎各健康研究存储的基线样本将被用来衡量有希望的 与T2D风险相关的代谢物，包括肠道微生物区系代谢物、尿素循环代谢物、2-氨基己二酸 酸、2-羟基丁酸、支链和芳香族氨基酸以及β-氨基异丁酸 120例T2D流行病例和120例匹配对照的有效病例对照研究设计。通过利用 在基线和两年内已经测量到的心脏代谢生物标志物，该项目还将评估 候选代谢物和T2D中间标记物之间的横断面和前瞻性关联。 除了这些目标之外，候选人还将1)识别与T2D相关的路径和签名，以及 2)检查主要代谢物的饮食来源。波士顿波多黎各健康研究非常适合 检查这些研究问题，因为它存储了生物标本和经过充分验证的饮食、生活方式、 以及特定种族的变量，如文化适应和感受到的压力。拟议研究的结果 可能有助于确定新的生物标记物和T2D的预防策略。世界一流的指导团队 是各自领域的领导者，再加上丰富的科学环境和资源，将确保 布帕提拉朱博士成功和无缝地过渡为营养方面的独立调查员， 代谢组学和慢性病流行病学。