Metabolomics and Type 2 Diabetes in a Cohort of Older Puerto Ricans

波多黎各老年群体的代谢组学和 2 型糖尿病

• 批准号: 9178206
• 负责人: Shilpa Nandana Bhupathiraju
• 金额: $ 14.95万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-14 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9178206
• 关键词: Acculturation; Acids; Address; Adult; Advisory Committees; Affect; Amino Acids; Aminoisobutyric Acids; Area; Aromatic Amino Acids; Betaine; Beverages; Biological; Biological Markers; Boston; Case-Control Studies; Cereals; Chemicals; Choline; Chronic Disease; Coffee; Cohort Studies; Complex; Data; Data Set; Development; Diabetes Mellitus; Diet; Dietary Factors; Dietary Practices; Disease; Educational workshop; Ensure; Environment; Epidemic; Epidemiologic Studies; Epidemiologist; Epidemiology; Fiber; Functional disorder; Genomics; Glutamates; Glutamine; Health; High Prevalence; Hispanics; Human; Hypertension; Inflammation; Institution; Interdisciplinary Study; K-Series Research Career Programs; Levocarnitine; Life; Life Style; Lipids; Measures; Meat; Medical Research; Mentors; Metabolic; Metabolic syndrome; Mexican Americans; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Organism; Pathway interactions; Phenotype; Plasma; Play; Population; Postdoctoral Fellow; Prevalence; Prevention strategy; Preventive Intervention; Productivity; Proteomics; Public Health; Public Health Schools; Puerto Rican; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk Factors; Role; Sampling; Schools; Secondary to; Source; Stress; System; Technology; Testing; Training; Work; cardiometabolic risk; career; cohort; design; diabetes risk; experience; gut microbiota; health disparity; high risk; high throughput technology; laboratory experience; meetings; metabolic profile; metabolomics; modifiable risk; novel; novel marker; nutrition; nutritional epidemiology; population based; prevent; programs; prospective; skills; symposium; tool; transcriptomics; trimethyloxamine; urea cycle

PROJECT SUMMARY This 4-year K01 career development award was designed to provide the necessary resources and training to the candidate, Dr. Shilpa N Bhupathiraju, to launch an independent research career in the field of nutrition and chronic disease epidemiology. The training plan includes a mixture of didactic course work, hands-on laboratory training, metabolomics workshops, seminars, advisory committee meetings, career enrichment programs, and attendance at national conferences. It is intended to provide Dr. Bhupathiraju with the necessary skill set in the emerging fields of metabolomics and systems epidemiology. Dr. Bhupathiraju is a highly motivated and capable young researcher with an established record of research productivity in the area of dietary and lifestyle determinants of chronic diseases. However, in order to achieve research independence, she will need to master novel analytic tools in nutritional epidemiology such as systems epidemiology and metabolomics. The proposed project will be implemented at the Harvard T.H. Chan School of Public Health. The school is adjacent to a wide range of research and medical institutions giving Dr. Bhupathiraju access to an enormous range and depth of scientific expertise, resources, and opportunities to advance her career and establish research independence. The proposed project is unique and timely as it is the first ever to evaluate novel and unexplored metabolic biomarkers of type 2 diabetes (T2D) in a group of older Puerto Ricans. Among all Hispanic sub-groups, Puerto Ricans experience the poorest health with excessive prevalence of T2D, metabolic syndrome, hypertension, and obesity. They have unique dietary patterns that may contribute to T2D risk. Stored baseline samples from the Boston Puerto Rican Health Study will be used to measure promising metabolites related to T2D risk, including gut microbiota metabolites, urea cycle metabolites, 2-aminoadipic acid, 2-hydroxybutanoic acid, branched chain and aromatic amino acids, and β-aminoisobutyric acid in an efficient case-control study design of 120 prevalent T2D cases and 120 matched controls. By taking advantage of already measured cardiometabolic biomarkers at baseline and 2-years, the project will also evaluate the cross-sectional and prospective associations between candidate metabolites and intermediate markers of T2D. Secondary to these aims, the candidate will also 1) identify pathways and signatures associated with T2D, and 2) examine dietary sources of key metabolites. The Boston Puerto Rican Health Study is well-suited to examine these research questions as it has stored biospecimens and well-validated measures of diet, lifestyle, and ethnic-specific variables such as acculturation and perceived stress. Findings from the proposed research may help identify novel biomarkers and prevention strategies for T2D. The world-class mentoring team who are leaders in their respective fields together with the rich scientific environment and resources will ensure the successful and seamless transition of Dr. Bhupathiraju into an independent investigator in nutrition, metabolomics, and chronic disease epidemiology.

项目概要 这个为期 4 年的 K01 职业发展奖旨在为以下人员提供必要的资源和培训： 候选人 Shilpa N Bhupathiraju 博士将在营养和营养领域开展独立研究生涯 慢性病流行病学。培训计划包括教学课程、实践活动 实验室培训、代谢组学讲习班、研讨会、咨询委员会会议、职业丰富 计划和出席国家会议。其目的是为 Bhupathiraju 博士提供 代谢组学和系统流行病学新兴领域的必要技能。 Bhupathiraju 博士是 积极主动、能力强的年轻研究人员，在该领域拥有良好的研究生产力记录 慢性病的饮食和生活方式决定因素。然而，为了实现研究独立， 她将需要掌握营养流行病学方面的新颖分析工具，例如系统流行病学和 代谢组学。拟议的项目将在哈佛大学 T.H.陈公共卫生学院。 学校毗邻众多研究和医疗机构，使 Bhupathiraju 博士能够获得 广泛而深入的科学专业知识、资源和机会来推动她的职业生涯和 建立研究独立性。拟议的项目是独一无二且及时的，因为它是第一个进行评估的项目 在一组老年波多黎各人中发现了 2 型糖尿病 (T2D) 的新颖且未经探索的代谢生物标志物。之中 所有西班牙裔亚群体中，波多黎各人的健康状况最差，T2D 患病率过高， 代谢综合征、高血压和肥胖。他们独特的饮食模式可能导致 T2D 风险。波士顿波多黎各健康研究中存储的基线样本将用于衡量有希望的 与 T2D 风险相关的代谢物，包括肠道微生物代谢物、尿素循环代谢物、2-氨基己二酸 酸、2-羟基丁酸、支链和芳香族氨基酸以及β-氨基异丁酸 对 120 例 T2D 流行病例和 120 例匹配对照进行有效的病例对照研究设计。通过利用 该项目还将评估基线和两年内已测量的心脏代谢生物标志物 T2D 候选代谢物和中间标志物之间的横断面和前瞻性关联。 除了这些目标之外，候选人还将 1) 确定与 T2D 相关的途径和特征，以及 2）检查关键代谢物的饮食来源。波士顿波多黎各健康研究非常适合 检查这些研究问题，因为它存储了生物样本和经过充分验证的饮食、生活方式、 以及特定种族的变量，例如文化适应和感知压力。拟议研究的结果 可能有助于识别 T2D 的新生物标志物和预防策略。世界一流的导师团队 各自领域的领先者加上丰富的科学环境和资源将确保 Bhupathiraju 博士成功无缝地转型为营养学领域的独立研究者， 代谢组学和慢性病流行病学。